Acoustical and volumetric investigation of polyethylene glycol 400 and polyethylene glycol 4000 in aqueous solutions of glycerol at different temperatures

2018 ◽  
Vol 127 ◽  
pp. 8-16 ◽  
Author(s):  
Kirandeep Kaur ◽  
K.C. Juglan ◽  
Harsh Kumar
Keyword(s):  
Polyethylene Glycol ◽  
Aqueous Solutions ◽  
Polyethylene Glycol 400 ◽  
Polyethylene Glycol 4000 ◽  
Different Temperatures

Solubility of mesalazine in polyethylene glycol 400 + water mixtures at different temperatures

2020 ◽  
Vol 314 ◽  
pp. 113546 ◽  
Author(s):  
Milad Moradi ◽  
Elaheh Rahimpour ◽  
Salar Hemmati ◽  
Fleming Martinez ◽  
Mohammad Barzegar-Jalali ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Polyethylene Glycol 400 ◽  
Different Temperatures

scholarly journals Povidone iodine loaded film-forming topical gel and evaluation of its chemical stability

2020 ◽  
Vol 11 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Jamal Mohamed A ◽  
Perinbam K ◽  
Vahitha V ◽  
Devanesan S ◽  
Janakiraman K K
Keyword(s):  
Polyethylene Glycol ◽  
Chemical Stability ◽  
Povidone Iodine ◽  
Wound Care ◽  
Aloe Vera ◽  
Polyethylene Glycol 400 ◽  
Protective Function ◽  
Polyethylene Glycol 4000 ◽  
Topical Gel ◽  
Film Forming

The main aim of this study was to develop Povidone Iodine loaded film-forming gel for excellent wound healing property with various formulations, and corresponding application stratification was prepared with Povidone Iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey. Povidone Iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds. Among the antiseptic and antimicrobial substances, Povidone-Iodine still occupies its position of lasting importance in everyday human and veterinary medicine. Povidone-iodine products display the broadest spectrum of antimicrobial effect with high clinical efficacy together with extremely low toxicity in clinical practice. The purpose served by dressing includes protecting wounds, promoting healing, and providing, retaining, or removing moisture. Wound repairing is a complex process involving an integrated response by many different cell types and growth factors to achieve rapid restoration of skin integrity and protective function after injury. In recent years, there have been tremendous advances in the design and composition of bandages and dressings, and there are numerous wound care materials. Some wound dressing types are biosynthetic dressings, composite dressings, gauze, hydrocolloid dressings, hydrogels, transparent films, etc. Povidone Iodine is completely soluble in cold and mild-warm water, ethyl alcohol, Iso propyl alcohol, Polyethylene glycol, and glycerol. The developed Povidone Iodine loaded film-forming gel was evaluated for their physical and chemical stability. The film-forming optimized gel formulation composed of povidone-iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey and this composition provides suitable consistency, spreadability, and adhesiveness. The prepared trials were coded PGAH-01, PGAH-02, PGAH-03, PGAH-04, and PGAH-05, respectively. Among these all formulations, the PGAH-04 formulation parameters was found within the limit.

Development, Evaluation and Optimization of Osmotic Controlled Tablets of Aceclofenac for Rheumatoid Arthritis Management

2019 ◽  
Vol 9 (1) ◽  
pp. 29-36
Author(s):  
Bijaya Ghosh ◽  
Niraj Mishra ◽  
Preeta Bose ◽  
Moumita D. Kirtania
Keyword(s):  
Rheumatoid Arthritis ◽  
Polyethylene Glycol ◽  
Sodium Chloride ◽  
Cellulose Acetate ◽  
Hydroxypropyl Methylcellulose ◽  
Release Profile ◽  
Polyethylene Glycol 400 ◽  
Permeable Membrane ◽  
Cumulative Release ◽  
The Core

Objective: Rheumatoid arthritis is a dreaded disease, characterized by pain, inflammation and stiffness of joints, leading to severe immobility problems. The disease shows circadian variation and usually gets aggravated in early morning hours. Aceclofenac, a BCS Class II compound is routinely used in the treatment of pain and inflammation associated with rheumatoid arthritis. The objective of this study was to develop an osmotic delivery system of Aceclofenac that after administration at bedtime would deliver the drug in the morning hours. </P><P> Methods: A series of osmotically controlled systems of aceclofenac was developed by using lactose, sodium chloride and hydroxypropyl methylcellulose K100M as osmogens. Cellulose acetate (2% w/v in acetone) with varying concentrations of polyethylene glycol-400 was used as the coating polymer to create semi permeable membrane and dissolution was carried out in 290 mOsm phosphate buffer. Formulation optimization was done from four considerations: cumulative release at the end of 6 hours (lag time), cumulative release at the end of 7 hours (burst time), steady state release rate and completeness of drug release. </P><P> Results: A formulation having swelling polymer hydroxypropyl methylcellulose in the core and lactose and sodium chloride as osmogens, polyethylene glycol-400 (16.39 %) as pore former, with a coating weight of 5% was a close fit to the target release profile and was chosen as the optimum formulation. Conclusion: Aceclofenac tablets containing lactose, HPMC and sodium chloride in the core, given a coating of cellulose acetate and PEG-400 (5% wt gain), generated a release profile for optimum management of rheumatoid arthritic pain.

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