“CoVidentary”: an online exercise training program to reduce sedentary behaviours in children with type 1 diabetes during the COVID-19 pandemic

Abstract Funding Acknowledgements Type of funding sources: None. Background Talk test (TT) is an alternative and accessible tool for prescribing and monitoring aerobic training intensity. Although the TT is reliable and valid for cardiorespiratory assessment, its responsiveness to exercise training remains unexplored. Purpose To evaluate the responsiveness of TT in cardiovascular disease (CVD) patients who underwent an exercise training program. Methods Twenty-one CVD patients (61.7 ± 8.4 years) performed an exercise-training program on phase II of cardiac rehabilitation (45-min 3-times a week). The six-minute walk test (6MWT) and TT were done to assess functional capacity at baseline and after 8 weeks. In the individualized TT the treadmill’s speed and/or grade were increased every 2-min, with speed changes based on a reference equation for the 6MWT distance (6MWD). The subjects were asked to read a 38 words standard paragraph at the last 30s of each stage and to answer if they could talk comfortably. Answer options were i) YES (TT+), ii) UNCERTAIN (TT±), or iii) NO (TT-). The first ventilatory threshold (VT1) was identified by two reviewers using the heart rate variability analysis. A paired t-test was applied to analyze the TT duration and 6MWD. The VT1 and TT workload were analyzed by the Wilcoxon test. Spearman correlation was adopted to compare the TT± and VT1 stages. Results Improvement in the VT1 (2.9 ± 1.2 vs 4.4 ± 1.4 min; p < 0.001), duration (12.1 ± 4.4 vs 14.9 ± 5.2 min; p < 0.001), workload at TT- (67.8 ± 48.4 vs 104.5 ± 65.9 w; p < 0.001), and in the 6MWD (471.5 ± 100.3 vs 533.7 ± 92.9 m; p < 0.001) were observed. There was strong correlation between TT± and VT1 in pre (r = 0.613; p < 0.05) and post-rehabilitation (r = 0.678; p < 0.05). Conclusion Talk test performed on a treadmill showed responsiveness after eight weeks of exercise training, being sensitive to the physiological changes provided by the rehabilitation program in CVD patients.

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The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents

Lipids in Health and Disease ◽

10.1186/s12944-021-01494-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

David P. McBey ◽

Michelle Dotzert ◽

C. W. J. Melling

Keyword(s):

Diabetes Mellitus ◽

Skeletal Muscle ◽

Type 1 Diabetes ◽

Exercise Training ◽

Muscle Fibre ◽

Lipid Content ◽

Fibre Type ◽

Insulin Treatment ◽

Type I

Abstract Background Intensive-insulin treatment (IIT) strategy for patients with type 1 diabetes mellitus (T1DM) has been associated with sedentary behaviour and the development of insulin resistance. Exercising patients with T1DM often utilize a conventional insulin treatment (CIT) strategy leading to increased insulin sensitivity through improved intramyocellular lipid (IMCL) content. It is unclear how these exercise-related metabolic adaptations in response to exercise training relate to individual fibre-type transitions, and whether these alterations are evident between different insulin strategies (CIT vs. IIT). Purpose: This study examined glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise-training. Methods Male Sprague-Dawley rats were divided into four groups: Control-Sedentary, CIT- and IIT-treated diabetic sedentary, and CIT-exercised trained (aerobic/resistance; DARE). After 12 weeks, muscle-fibre lipids and glycogen were compared through immunohistochemical analysis. Results The primary findings were that both IIT and DARE led to significant increases in type I fibres when compared to CIT, while DARE led to significantly increased lipid content in type I fibres compared to IIT. Conclusions These findings indicate that alterations in lipid content with insulin treatment and DARE are primarily evident in type I fibres, suggesting that muscle lipotoxicity in type 1 diabetes is muscle fibre-type dependant.

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