In situ bioadhesive film-forming system for topical delivery of mometasone furoate: Characterization and biopharmaceutical properties

Numerous groundwater sites around the globe have been contaminated by aqueous film forming foam (AFFF) as a result of firefighting, fire training activities and the storage and accidental spillage of AFFF.

Download Full-text

In Situ Gel Formation in Microporated Skin for Enhanced Topical Delivery of Niacinamide

Pharmaceutics ◽

10.3390/pharmaceutics12050472 ◽

2020 ◽

Vol 12 (5) ◽

pp. 472 ◽

Cited By ~ 1

Author(s):

Sonalika Bhattaccharjee ◽

Moritz Beck-Broichsitter ◽

Ajay K. Banga

Keyword(s):

Molecular Weight ◽

Sol Gel ◽

Topical Delivery ◽

Needle Length ◽

Molecular Weight Polymer ◽

Sol Gel Transition ◽

Pre Treatment ◽

Franz Diffusion Cells

Although used widely in cosmetic formulations, topical delivery of niacinamide (LogP = −0.35) is unfavorable by conventional means. Poly(lactide-co-glycolide) (PLGA) formulations, can undergo a sol-gel transition triggered by solvent exchange, entrapping molecules and sustaining their release. The current study aims to exploit the ability of PLGA to gel in situ and enhance the topical delivery of niacinamide in microporated skin. In vitro drug permeation studies were performed using vertical Franz diffusion cells. Microporation was performed using Dr. PenTM Ultima A6, where pre-treatment with a 1 mm needle-length for 10 s and a 0.5 mm needle-length for 5 s, both at 13,000 insertions/min were compared. The effect of different grades of PLGA, EXPANSORB® DLG 50-2A (“low” molecular weight), and EXPANSORB® DLG 50-8A (“high” molecular weight) on topical delivery was also determined. Formulations containing PLGA resulted in successful gelation in situ on application over microporated skin. A significantly higher amount of drug was found in the skin with the 0.5 mm treatment for 5 s (892 ± 36 µg/cm2) than with 1 mm for 10 s (167 ± 16 µg/cm2). Hence, the different grades of PLGA were evaluated with 0.5 mm, 5 s treatment, and a significantly larger amount was seen in skin with the higher rather than the lower molecular weight polymer (172 ± 53 µg/cm2).

Download Full-text

Design and Evaluation of a Poly(Lactide-co-Glycolide)-Based In Situ Film-Forming System for Topical Delivery of Trolamine Salicylate

Pharmaceutics ◽

10.3390/pharmaceutics11080409 ◽

2019 ◽

Vol 11 (8) ◽

pp. 409 ◽

Cited By ~ 2

Author(s):

Yujin Kim ◽

Moritz Beck-Broichsitter ◽

Ajay Banga

Keyword(s):

Porcine Skin ◽

Adhesive Film ◽

Film Forming ◽

Small Joint ◽

Gastrointestinal Side Effects ◽

Permeation Studies ◽

Polymeric Solutions ◽

Poly Ethylene

Trolamine salicylate (TS) is a topical anti-inflammatory analgesic used to treat small joint pain. The topical route is preferred over the oral one owing to gastrointestinal side effects. In this study, a poly(lactide-co-glycolide) (PLGA)-based in situ bio-adhesive film-forming system for the transdermal delivery of TS was designed and evaluated. Therefore, varying amounts (0%, 5%, 10%, 20%, and 25% (w/w)) of PLGA (EXPANSORB® DLG 50-2A, 50-5A, 50-8A, and 75-5A), ethyl 2-cyanoacrylate, poly (ethylene glycol) 400, and 1% of TS were dissolved together in acetone to form the bio-adhesive polymeric solution. In vitro drug permeation studies were performed on a vertical Franz diffusion cell and dermatomed porcine ear skin to evaluate the distinct formulations. The bio-adhesive polymeric solutions were prepared successfully and formed a thin film upon application in situ. A significantly higher amount of TS was delivered from a formulation containing 20% PLGA (45 ± 4 µg/cm2) and compared to PLGA-free counterpart (0.6 ± 0.2 µg/cm2). Furthermore, the addition of PLGA to the polymer film facilitated an early onset of TS delivery across dermatomed porcine skin. The optimized formulation also enhanced the delivery of TS into and across the skin.

Download Full-text

In situ characterization of the SEI formation on graphite in the presence of a vinylene group containing film-forming electrolyte additives

Journal of Power Sources ◽

10.1016/s0378-7753(03)00289-1 ◽

2003 ◽

Vol 119-121 ◽

pp. 561-566 ◽

Cited By ~ 79

Author(s):

K.-C. Möller ◽

H.J. Santner ◽

W. Kern ◽

S. Yamaguchi ◽

J.O. Besenhard ◽

...

Keyword(s):

In Situ Characterization ◽

Electrolyte Additives ◽

Film Forming

Download Full-text

In situ film forming fibroin gel intended for cutaneous administration

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2016.07.013 ◽

2016 ◽

Vol 511 (1) ◽

pp. 296-302 ◽

Cited By ~ 5

Author(s):

Chiara G.M. Gennari ◽

Francesca Selmin ◽

Marco A. Ortenzi ◽

Silvia Franzé ◽

Umberto M. Musazzi ◽

...

Keyword(s):

Film Forming ◽

Cutaneous Administration

Download Full-text

Nanocomposites Based on Montmorillonite/Acrylic Copolymer for Aqueous Coating of Soft Surfaces

Solid State Phenomena ◽

10.4028/www.scientific.net/ssp.151.129 ◽

2009 ◽

Vol 151 ◽

pp. 129-134 ◽

Cited By ~ 2

Author(s):

Onur Yılmaz ◽

Aurica P. Chiriac ◽

Catalina Natalia Cheaburu ◽

Loredana E. Nita ◽

Gürbüz Gülümser ◽

...

Keyword(s):

Mechanical Properties ◽

Layered Silicate ◽

Acrylic Copolymer ◽

Modified Montmorillonite ◽

Organically Modified Montmorillonite ◽

Film Forming ◽

Organically Modified ◽

Polymerization Method ◽

Structural Characterizations

Nanocomposites based on layered silicate organically modified montmorillonite (Cloisite 20A) and acrylic comonomers (butyl acrylate and methyl methacrylate) were prepared by simple “in situ” batch emulsion polymerization method. The particle size and zeta potential of the emulsions were analyzed. The structural characterizations of the nanocomposites were performed by FTIR, thermal behaviors of the films were investigated by DSC, mechanical properties of the films were tested by DMA and intercalation success was viewed by XRD. The mechanical properties of the nanocomposites were improved significantly especially at the temperatures above Tg. The ultrasonication process was found to be useful for increasing the homogeneity of the emulsions and intercalation success. The obtained nanocomposite emulsions were applied on garment leathers in a finishing formulation as aqueous binders sharing good film forming ability and elasticity.

Download Full-text