Inflammatory skin march: A concept for IL-1 mediated skin inflammation to cardio-vascular events including atopic dermatitis and psoriasis

2016 ◽  
Vol 84 (1) ◽  
pp. e95-e96
Author(s):  
Keiichi Yamanaka ◽  
Hitoshi Mizutani
Keyword(s):  
Atopic Dermatitis ◽  
Skin Inflammation ◽  
Vascular Events ◽  
Inflammatory Skin ◽  
Cardio Vascular

scholarly journals The role of gut microbiome in inflammatory skin disorders: a systematic review

2021 ◽  
Author(s):  
Suci Widhiati ◽  
Dewajani Purnomosari ◽  
Tri Wibawa ◽  
Hardyanto Soebono
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Chronic Urticaria ◽  
Gut Microbiome ◽  
Acne Vulgaris ◽  
Skin Inflammation ◽  
Skin Disorders ◽  
Skin Manifestations ◽  
Close Relationship ◽  
Inflammatory Skin

The close relationship between the intestine and the skin has been widely stated, seen from gastrointestinal (GI) disorders often accompanied by skin manifestations. Exactly how the gut microbiome is related to skin inflammation and influences the pathophysiology mechanism of skin disorders are still unclear. Many studies have shown a two-way relationship between gut and skin associated with GI health and skin homeostasis and allostasis. This systematic review aimed to explore the associations between the gut microbiome with inflammatory skin disorders, such as acne, psoriasis, atopic dermatitis, and urticaria, and to discover the advanced concept of this relationship. Methods: The literature search was limited to any articles published up to December 2020 using PubMed and EBSCOHost. The review followed the PRISMA guidelines for conducting a systematic review. Result: Of the 319 articles screened based on title and abstract, 111 articles underwent full-text screening. Of these, 23 articles met our inclusion criteria, comprising 13 AD, three psoriasis, four acne vulgaris, and four chronic urticaria articles. Discussion: Acne vulgaris, atopic dermatitis, psoriasis, and chronic urticaria are inflammation skin disorders that were studied recently to ascertain the relationship of these disorders with dysbiosis of the GI microbiome. All acne vulgaris, psoriasis, and chronic urticaria studies stated the association of gut microbiome with skin manifestations. However, the results in atopic dermatitis are still conflicting. Most of the articles agree that Bifidobacterium plays an essential role as anti-inflammation bacteria, and Proteobacteria and Enterobacteria impact inflammation in inflammatory skin disorder.

Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis‐like mouse model

2021 ◽  
Author(s):  
Natalija Novak ◽  
Heike Weighardt ◽  
Rafael Valdelvira ◽  
Elena Izquierdo ◽  
Irmgard Förster ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Mouse Model ◽  
Skin Inflammation ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis

2015 ◽  
Vol 165 ◽  
pp. 54-60 ◽  
Author(s):  
Bo-Kyung Park ◽  
Yang-Chun Park ◽  
In Chul Jung ◽  
Seung-Hyung Kim ◽  
Jeong June Choi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Murine Model ◽  
Skin Inflammation ◽  
Atopic Skin

scholarly journals Aspirin use for primary prevention in elderly patients

2016 ◽  
Vol 84 (1-2) ◽  
Author(s):  
Pierfranco Terrosu
Keyword(s):  
Primary Prevention ◽  
Older People ◽  
Meta Analysis ◽  
Vascular Risk ◽  
Vascular Events ◽  
Rischio Cardiovascolare ◽  
Increased Risk ◽  
Coronary Events ◽  
Cardio Vascular ◽  
Net Clinical Benefit

<p>The net clinical benefit of aspirin in primary prevention is uncertain as the reduction in occlusive events needs to be balanced against the increase in gastro-intestinal and cerebral bleedings. The meta-analysis of ATT (Anti Thrombotic Trialists) Collaboration in 2009 showed that aspirin therapy in primary prevention was associated with 12% reduction in cardio-vascular events, due mainly to a reduction in non-fatal myocardial infarction (0.18% vs 0.23% per year, p&lt;0.0001). However, the benefit in term of coronary events was almost balanced by the increase in major bleedings. The balance between potential benefit and harm of aspirin differs in each person and appears to be favorable in subjects at higher cardio-vascular risk. Older people have increased risk of hemorrhage as well as increased risk of heart attack and stroke. As a consequence, it is important consider both likelihoods of benefits as well as harm within the lifespan and functioning of the person. The older people who most likely benefit from aspirin in primary prevention are those at higher cardio-vascular risk, with preserved functional abilities, low comorbidity, low risk of bleeding and a prolonged life expectancy.</p><p> </p><p><strong>Riassunto</strong></p><p>Il beneficio clinico netto dell’aspirina in prevenzione primaria è poco chiaro, a causa del bilancio critico tra riduzione delle occlusioni vascolari e aumento dei sanguinamenti gastro-intestinali e cerebrali. La metanalisi del 2009 del ATT (Anti Thrombotic Trialists) Collaboration mostra che l’aspirina in prevenzione primaria determina una riduzione del 12% degli eventi cardiovascolari, principalmente dovuta ad una riduzione dell’infarto miocardico non-fatale (0.18% vs 0.23% per anno, p&lt;0.0001). Tuttavia il beneficio in termini di eventi coronarici è controbilanciato dall’incremento dei sanguinamenti maggiori. Ne deriva che il bilancio tra vantaggi ed effetti avversi differisce nel singolo soggetto ed appare potenzialmente favorevole nei casi a più elevato rischio cardiovascolare. Nella popolazione anziana è aumentato sia il rischio trombotico che quello emorragico. Di conseguenza, è importante considerare il rapporto rischio/beneficio in relazione alla aspettativa di vita e alla capacità funzionale. In sostanza gli anziani che possono trarre vantaggio dall’aspirina in prevenzione primaria sono quelli a più alto rischio cardiovascolare, con mobilità conservata, scarsa comorbidità, basso rischio emorragico e lunga aspettativa di vita.</p>

scholarly journals Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice

2006 ◽  
Vol 103 (23) ◽  
pp. 8816-8821 ◽  
Author(s):  
M. Terada ◽  
H. Tsutsui ◽  
Y. Imai ◽  
K. Yasuda ◽  
H. Mizutani ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Skin Inflammation
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