Cardiac Adverse Event in Apheresis Donation and Significance of Two-Dimensional Repolarization Function Diagram

Two dimensional code security system can be used to encrypt the user is decoded product, inspection by anti fake system or mobile phone software, can be genuine security information products. The Fourier transform of the amendment in the two-dimensional code patterns on the basis, transforming it into the function value is input to the server system. After a raster image processor (RIP) to draw the value of Bessel curve fitting, and tend to image in a plurality of sine function description, at the same time using the Visual Basic to draw a sinusoidal function diagram, the output image information two-dimensional code generation. Finally, through the internal matching storage printing output pattern and server security code information, you can verify the authenticity of products. It provides a simple and convenient method, and accurate for the commodity information traceability and product anti-counterfeiting identification.

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PP118 Cardiac Safety Of Trastuzumab For Metastatatic Breast Cancer

International Journal of Technology Assessment in Health Care ◽

10.1017/s0266462318002556 ◽

2018 ◽

Vol 34 (S1) ◽

pp. 111-111

Author(s):

Livia Lovato Pires de Lemos ◽

Paulo Henrique Ribeiro Fernandes Almeida ◽

Juliana Alvares ◽

Roberta Rabelo ◽

Vania Canuto Santos ◽

...

Keyword(s):

Breast Cancer ◽

Adverse Event ◽

Metastatic Breast ◽

Cochrane Library ◽

Line Treatment ◽

First Line ◽

Eligibility Criteria ◽

Cardiac Adverse Event ◽

Manual Search ◽

First Line Treatment

Introduction:Metastatic breast cancer (MBC) is considered incurable. Trastuzumab (T), a monoclonal antibody that blocks HER-2 is used in combination with other chemotherapies or as monotherapy to treat various stages of breast cancer, including MBC. The aim of this study was to evaluate the safety of T as first line treatment or after progression in women with MBC.Methods:We conducted a systematic review of randomized controlled trials. We searched the databases: MEDLINE (Pubmed), LILACS, Cochrane Library and EMBASE (accessed November 2016) and performed manual search. The methodological quality assessment was performed using the Cochrane Collaboration risk of bias tool. We adopted the random effects model for meta-analysis. The results were presented as relative risk (RR) with 95% confidence intervals.Results:The search retrieved 2,238 publications. After eligibility criteria assessment we included five studies on T in the first line treatment (T n = 493; no-T n = 492) and two studies on T after progression (T n = 226; no-T n = 226). In general, studies presented moderate quality. Five were funded by the pharmaceutical industry. Regarding first line treatment, the group of patients that used T had three times higher risk of developing cardiac adverse event compared to the group that did not use T (RR = 3.3; 95% CI: 1.52 − 7.29; I2 = 0%, p = 0.39). The continuity of T after progression revealed no difference between the groups regarding the risk of developing cardiac adverse event (RR = 5.31; 95% CI: 0.62 − 45.49; I2 = 0%, p = 0.62).Conclusions:The evidence regarding the higher risk of cardiac adverse event with T as first line treatment for MBC is robust and this should be taken into account when balancing risks and benefits of treatment. The evidence for continuation of T after MCB progression is week and more studies are needed to confirm the findings.

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T28. BENEFITS AND HARMS OF ANTIPSYCHOTICS IN THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH SCHIZOPHRENIA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Schizophrenia Bulletin ◽

10.1093/schbul/sbaa029.588 ◽

2020 ◽

Vol 46 (Supplement_1) ◽

pp. S242-S242

Author(s):

Katsuhiko Hagi ◽

Tadashi Nosaka ◽

Andrei Pikalov

Keyword(s):

Systematic Review ◽

Adverse Event ◽

Meta Analysis ◽

Cochrane Library ◽

Two Dimensional ◽

Primary Efficacy ◽

Efficacy And Safety ◽

Electronic Search ◽

Clinical Benefits ◽

Dimensional Graph

Abstract Background Childhood and adolescent schizophrenia is a severe and debilitating disorder associated with long-term impairments in functioning, poor physical health, and reduced life expectancy. Compared with adult-onset schizophrenia, childhood and adolescent schizophrenia may be a more severe disorder, negatively influencing social, cognitive and psychological development, educational achievements and life-long occupational functioning. Therefore, treatment of childhood and adolescent schizophrenia is highly important and presents a major therapeutic challenge. The aim of this systematic review and meta-analysis was to assess whether antipsychotics (APs) have different clinical benefits and harms profiles in acute treatment of childhood and adolescent schizophrenia. Methods We conducted systematic review and meta-analysis of randomized placebo-controlled trials (RCTs) assessing efficacy and adverse effects of APs in acute childhood and adolescent schizophrenia to compare clinical benefits and harms. An electronic search was conducted without language restrictions using Embase, Scopus, MEDLINE/PubMed, the Cochrane library, and the US National Institutes of Health clinical trials registry (http://www.clinicaltrials.gov). The electronic search was supplemented by a hand search of reference lists of relevant studies and reviews. The primary efficacy outcome examined was treatment response. The primary safety/tolerability was assessed based on discontinuation due to adverse event. In order to visualize the risk and benefit tradeoff of each AP, risk ratios (RRs) were plotted on two-dimensional graph for the primary efficacy and safety/tolerability outcomes. Results Ten studies were selected, comprising of 2,271 patients across eight active interventions (aripiprazole, asenapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone) and placebo. The mean intervention duration was 6.4 weeks (range 6–8 weeks). Lurasidone, asenapine and risperidone had significantly higher response rate (RR = 1.54, 95% CI = 1.21 to 1.95, p<0.001; RR = 1.38, 95% CI = 1.02 to 1.85, p=0.035; and RR = 1.71, 95% CI = 1.39 to 2.11, p<0.001, respectively) compared with placebo. These three antipsychotics also had significant single digit numbers needed to treat (NNT = 5, 4, and 8, respectively). All APs did not significantly separate from placebo in discontinuation rate due to adverse event compared with placebo (RR = 0.47 to 5.42). Aripiprazole had the significant number needed to harm (NNH = 25). On a two-dimensional graph plot of efficacy and safety/tolerability, lurasidone showed the most desirable profile for the risk / benefit tradeoff balance among all antipsychotics. Discussion Results from this meta-analysis illustrate that there are significant differences in benefits and harms among APs in the treatment of childhood and adolescent schizophrenia. Medications choice needs to be carefully evaluated to achieve optimal clinical benefit while minimizing burden of side effects for the patients.

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Spectrophotometric measurements of objective-prism spectra

Symposium - International Astronomical Union ◽

10.1017/s007418090005333x ◽

1966 ◽

Vol 24 ◽

pp. 118-119

Author(s):

Th. Schmidt-Kaler

Keyword(s):

Progress Report ◽

Two Dimensional ◽

Objective Prism ◽

Made In

I should like to give you a very condensed progress report on some spectrophotometric measurements of objective-prism spectra made in collaboration with H. Leicher at Bonn. The procedure used is almost completely automatic. The measurements are made with the help of a semi-automatic fully digitized registering microphotometer constructed by Hög-Hamburg. The reductions are carried out with the aid of a number of interconnected programmes written for the computer IBM 7090, beginning with the output of the photometer in the form of punched cards and ending with the printing-out of the final two-dimensional classifications.

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Introductory paper

Symposium - International Astronomical Union ◽

10.1017/s0074180900053031 ◽

1966 ◽

Vol 24 ◽

pp. 3-5

Author(s):

W. W. Morgan

Keyword(s):

Line Intensity ◽

Classification Scheme ◽

Two Dimensional ◽

Spectral Classification ◽

Dimensional Array ◽

Rr Lyrae ◽

Metallic Line ◽

Introductory Paper ◽

Parameter Varying ◽

Definition Of

1. The definition of “normal” stars in spectral classification changes with time; at the time of the publication of theYerkes Spectral Atlasthe term “normal” was applied to stars whose spectra could be fitted smoothly into a two-dimensional array. Thus, at that time, weak-lined spectra (RR Lyrae and HD 140283) would have been considered peculiar. At the present time we would tend to classify such spectra as “normal”—in a more complicated classification scheme which would have a parameter varying with metallic-line intensity within a specific spectral subdivision.

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A one-dimensional self-gravitating stellar gas

Symposium - International Astronomical Union ◽

10.1017/s0074180900105261 ◽

1966 ◽

Vol 25 ◽

pp. 46-48 ◽

Cited By ~ 2

Author(s):

M. Lecar

Keyword(s):

Gravitational Field ◽

Phase Space ◽

Motion Picture ◽

Space Distribution ◽

Two Dimensional ◽

One Dimensional ◽

Phase Space Distribution ◽

Dimensional Phase Space ◽

The Mean

“Dynamical mixing”, i.e. relaxation of a stellar phase space distribution through interaction with the mean gravitational field, is numerically investigated for a one-dimensional self-gravitating stellar gas. Qualitative results are presented in the form of a motion picture of the flow of phase points (representing homogeneous slabs of stars) in two-dimensional phase space.

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Analysis of the 9th November 1990 flare

International Astronomical Union Colloquium ◽

10.1017/s025292110006454x ◽

2000 ◽

Vol 179 ◽

pp. 229-232

Author(s):

Anita Joshi ◽

Wahab Uddin

Keyword(s):

Image Processing ◽

Two Dimensional ◽

Temporal Behaviour ◽

Contour Maps ◽

Dimensional Measurements ◽

Processing Software ◽

Image Processing Software

AbstractIn this paper we present complete two-dimensional measurements of the observed brightness of the 9th November 1990Hαflare, using a PDS microdensitometer scanner and image processing software MIDAS. The resulting isophotal contour maps, were used to describe morphological-cum-temporal behaviour of the flare and also the kernels of the flare. Correlation of theHαflare with SXR and MW radiations were also studied.

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High Resolution Microscopy of Multi-Layered Biological Crystals

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010005319x ◽

1982 ◽

Vol 40 ◽

pp. 80-83

Author(s):

H.A. Cohen ◽

T.W. Jeng ◽

W. Chiu

Keyword(s):

High Resolution ◽

Low Dose ◽

Three Dimensional ◽

Data Interpretation ◽

Two Dimensional ◽

Biological Objects ◽

Density Maps ◽

Density Map ◽

Complex Crystal ◽

High Resolution Microscopy

This tutorial will discuss the methodology of low dose electron diffraction and imaging of crystalline biological objects, the problems of data interpretation for two-dimensional projected density maps of glucose embedded protein crystals, the factors to be considered in combining tilt data from three-dimensional crystals, and finally, the prospects of achieving a high resolution three-dimensional density map of a biological crystal. This methodology will be illustrated using two proteins under investigation in our laboratory, the T4 DNA helix destabilizing protein gp32*I and the crotoxin complex crystal.

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