Age Still Matters: Prognosticating Short- and Long-term Mortality for Critically Ill Patients with Pneumonia

AbstractDecreased glomerular filtration rate (GFR) is linked to poor survival. The predictive value of creatinine estimated GFR (eGFR) and cystatin C eGFR in critically ill patients may differ substantially, but has been less studied. This study compares long-term mortality risk prediction by eGFR using a creatinine equation (CKD-EPI), a cystatin C equation (CAPA) and a combined creatinine/cystatin C equation (CKD-EPI), in 22,488 patients treated in intensive care at three University Hospitals in Sweden, between 2004 and 2015. Patients were analysed for both creatinine and cystatin C on the same blood sample tube at admission, using accredited laboratory methods. During follow-up (median 5.1 years) 8401 (37%) patients died. Reduced eGFR was significantly associated with death by all eGFR-equations in Cox regression models. However, patients reclassified to a lower GFR-category by using the cystatin C-based equation, as compared to the creatinine-based equation, had significantly higher mortality risk compared to the referent patients not reclassified. The cystatin C equation increased C-statistics for death prediction (p < 0.001 vs. creatinine, p = 0.013 vs. combined equation). In conclusion, this data favours the sole cystatin C equation rather than the creatinine or combined equations when estimating GFR for risk prediction purposes in critically ill patients.

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Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study

Canadian Medical Association Journal ◽

10.1503/cmaj.130639 ◽

2013 ◽

Vol 186 (2) ◽

pp. E95-E102 ◽

Cited By ~ 226

Author(s):

S. M. Bagshaw ◽

H. T. Stelfox ◽

R. C. McDermid ◽

D. B. Rolfson ◽

R. T. Tsuyuki ◽

...

Keyword(s):

Cohort Study ◽

Critically Ill ◽

Prospective Cohort Study ◽

Critically Ill Patients ◽

Prospective Cohort ◽

Long Term Outcomes ◽

Short And Long Term

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Anemia Is a Risk Factor for Acute Kidney Injury and Long-Term Mortality in Critically Ill Patients

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.237.287 ◽

2015 ◽

Vol 237 (4) ◽

pp. 287-295 ◽

Cited By ~ 14

Author(s):

Seung Seok Han ◽

Seon Ha Baek ◽

Shin Young Ahn ◽

Ho Jun Chin ◽

Ki Young Na ◽

...

Keyword(s):

Acute Kidney Injury ◽

Risk Factor ◽

Critically Ill ◽

Critically Ill Patients ◽

Kidney Injury ◽

Long Term Mortality

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Short- and Long-term Outcomes of Critically Ill Patients With Cancer and Prolonged ICU Length of Stay

CHEST Journal ◽

10.1378/chest.08-0359 ◽

2008 ◽

Vol 134 (3) ◽

pp. 520-526 ◽

Cited By ~ 56

Author(s):

Márcio Soares ◽

Jorge I.F. Salluh ◽

Viviane B.L. Torres ◽

Juliana V.R. Leal ◽

Nelson Spector

Keyword(s):

Length Of Stay ◽

Critically Ill ◽

Critically Ill Patients ◽

Long Term Outcomes ◽

Patients With Cancer ◽

Icu Length Of Stay ◽

Short And Long Term

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A Retrospective Cohort Study on the Association between Red Cell Distribution Width and All-Cause Mortality of Patients with Cholecystitis at ICU Admission

Disease Markers ◽

10.1155/2021/9625220 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Yihua Dong ◽

Yu Pan ◽

Wei Zhou ◽

Yanhuo Xia ◽

Jingye Pan

Keyword(s):

Hospital Mortality ◽

Critically Ill ◽

Regression Models ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Prognostic Effect ◽

Short And Long Term ◽

Long Term Mortality

Background. Elevated red cell distribution width (RDW) has been reported to be associated with mortality in some critically ill patient populations. The aim of this article is to investigate the relationship between RDW and in-hospital mortality and short- and long-term mortality of patients with cholecystitis. Method. We conducted a retrospective cohort study in which data from all 702 patients extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database were used. Receiver operating characteristic (ROC) curves were constructed to evaluate the prognostic predictive value of RDW for in-hospital mortality and short- (i.e., 30-day and 90-day) and long-term (i.e., 180-day, 1-year, 3-year, and 5-year) mortality. We converted RDW into a categorical variable according to quintiles as less than or equal to 13.9%, 14.0-14.8%, 14.9-15.8%, and 15.9-17.2% and more than 17.2%. The Kaplan-Meier (K-M) methods and log-rank tests were used to compare survival differences among different groups. The relationships between RDW levels and in-hospital mortality were evaluated by univariate and multivariate binary logistic regression models. Multivariable Cox regression models were built to investigate the association of RDW on the short-term and long-term mortality. Result. After adjusting for potential confounders, RDW was positively associated with in-hospital mortality (OR: 1.187, 95% CI [1.049, 1.343]) and short- (i.e., 30-day: HR: 1.183, 95% CI [1.080, 1.295], 90-day: HR: 1.175, 95% CI [1.089, 1.268]) and long-term (i.e., 1-year: HR:1.162, 95% CI [1.089, 1.240]) mortality in critically ill patients with cholecystitis. Similar results were also shown in the secondary outcomes of 180-day, 3-year, and 5-year mortality. RDW had a significant accurate prognostic effect on different endpoints and could improve the prognostic effect of scoring systems. Conclusion. High level of RDW is associated with an increased risk of in-hospital mortality and short- and long-term mortality in critically ill patients with cholecystitis. RDW can independently predict the prognosis of patients with cholecystitis.

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Short- and long-term prognosis of acute critically ill patients with systemic rheumatic diseases

Medicine ◽

10.1097/md.0000000000026164 ◽

2021 ◽

Vol 100 (35) ◽

pp. e26164

Author(s):

Paul Chabert ◽

William Danjou ◽

Mehdi Mezidi ◽

Julien Berthiller ◽

Audrey Bestion ◽

...

Keyword(s):

Critically Ill ◽

Rheumatic Diseases ◽

Critically Ill Patients ◽

Systemic Rheumatic Diseases ◽

Short And Long Term ◽

Long Term Prognosis

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Sex Differences in Short- and Long-Term Survival Among Critically Ill Patients with Sepsis

International Journal of General Medicine ◽

10.2147/ijgm.s294229 ◽

2021 ◽

Vol Volume 14 ◽

pp. 613-622

Author(s):

Shan Lin ◽

Wanmei He ◽

Zixuan Hu ◽

Lihong Bai ◽

Mian Zeng

Keyword(s):

Sex Differences ◽

Critically Ill ◽

Critically Ill Patients ◽

Term Survival ◽

Long Term Survival ◽

Short And Long Term

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The association between culture positivity and long-term mortality in critically ill surgical patients

Journal of Intensive Care ◽

10.1186/s40560-021-00576-2 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Yu-Cheng Wu ◽

Li-Ting Wong ◽

Chieh-Liang Wu ◽

Wen-Cheng Chao

Keyword(s):

Critically Ill ◽

Critically Ill Patients ◽

Positive Culture ◽

Surgical Patients ◽

Term Outcome ◽

Long Term Outcome ◽

Culture Positivity ◽

Critically Ill Surgical Patients ◽

Long Term Mortality

Abstract Background The long-term outcome is an essential issue in critically ill patients, and the identification of early determinant is needed for risk stratification of the long-term outcome. In the present study, we investigate the association between culture positivity during admission and long-term outcome in critically ill surgical patients. Methods We linked the 2015–2019 critical care database at Taichung Veterans General Hospital with the nationwide death registration files in Taiwan. We described the long-term mortality and proportion of culture positivity among enrolled subjects. We used a log-rank test to estimate survival curves between patients with and without positive cultures and a multivariable Cox proportional hazards regression model to determine hazard ratio (HR) and 95% confidence interval (CI). Results A total of 6748 critically ill patients were enrolled, and 32.5% (2196/6749) of them died during the follow-up period, with the overall follow-up duration was 1.8 ± 1.4 years. We found that 31.4% (2122/6748) of critically ill patients had at least one positive culture during the index admission, and the number of patients with positive culture in the blood, respiratory tract, urinary tract, skin and soft tissue and abdomen were 417, 1702, 554, 194 and 139, respectively. We found that a positive culture from any sites was independently associated with high long-term mortality (aHR 1.579, 95% CI 1.422–1.754) after adjusting relevant covariates, including age, sex, body-mass index, comorbidities, severity score, shock, early fluid overload, receiving mechanical ventilation and the need of renal replacement therapy for critical illness. Conclusions We linked two databases to identify that a positive culture during admission was independently correlated with increased long-term mortality in critically ill surgical patients. Our findings highlight the need for vigilance among patients with a positive culture during admission, and more studies are warranted to validate our findings and to clarify underlying mechanisms.

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