Post-traumatic Stress Disorder in an Emergency Department Population One Year after Hurricane Katrina

2012 ◽  
Vol 43 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Lisa D. Mills ◽  
Trevor J. Mills ◽  
Marlow Macht ◽  
Rachel Levitan ◽  
Annelies De Wulf ◽  
...  
2019 ◽  
Vol 45 (6) ◽  
pp. 940-946 ◽  
Author(s):  
Nicholas J. Petrosino ◽  
Mascha van ’t Wout-Frank ◽  
Emily Aiken ◽  
Hannah R. Swearingen ◽  
Jennifer Barredo ◽  
...  

AbstractTheta burst transcranial magnetic stimulation (TBS) is a potential new treatment for post-traumatic stress disorder (PTSD). We previously reported active intermittent TBS (iTBS) was associated with superior clinical outcomes for up to 1-month, in a sample of fifty veterans with PTSD, using a crossover design. In that study, participants randomized to the active group received a total of 4-weeks of active iTBS, or 2-weeks if randomized to sham. Results were superior with greater exposure to active iTBS, which raised the question of whether observed effects persisted over the longer-term. This study reviewed naturalistic outcomes up to 1-year from study endpoint, to test the hypothesis that greater exposure to active iTBS would be associated with superior outcomes. The primary outcome measure was clinical relapse, defined as any serious adverse event (e.g., suicide, psychiatric hospitalization, etc.,) or need for retreatment with repetitive transcranial magnetic stimulation (rTMS). Forty-six (92%) of the initial study’s intent-to-treat participants were included. Mean age was 51.0 ± 12.3 years and seven (15.2%) were female. The group originally randomized to active iTBS (4-weeks active iTBS) demonstrated superior outcomes at one year compared to those originally randomized to sham (2-weeks active iTBS); log-rank ChiSq = 5.871, df = 1, p = 0.015; OR = 3.50, 95% CI = 1.04–11.79. Mean days to relapse were 296.0 ± 22.1 in the 4-week group, and 182.0 ± 31.9 in the 2-week group. When used, rTMS retreatment was generally effective. Exploratory neuroimaging revealed default mode network connectivity was predictive of 1-year outcomes (corrected p < 0.05). In summary, greater accumulated exposure to active iTBS demonstrated clinically meaningful improvements in the year following stimulation, and default mode connectivity could be used to predict longer-term outcomes.


2017 ◽  
Vol 34 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Juliet Haarbauer-Krupa ◽  
Christopher A. Taylor ◽  
John K. Yue ◽  
Ethan A. Winkler ◽  
Romain Pirracchio ◽  
...  

2010 ◽  
Vol 5 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Xu Xiong, MD, DrPH ◽  
Emily W. Harville, PhD ◽  
Donald R. Mattison, MD ◽  
Karen Elkind-Hirsch, PhD ◽  
Gabriella Pridjian, MD ◽  
...  

Objective: Little is known about the effects of disaster exposure and intensity on the development of mental disorders among pregnant women. The aim of this study was to examine the effect of exposure to Hurricane Katrina on mental health in pregnant women.Design: Prospective cohort epidemiological study.Setting: Tertiary hospitals in New Orleans and Baton Rouge, USA.Participants: Women who were pregnant during Hurricane Katrina or became pregnant immediately after the hurricane.Main outcome measures: Post-traumatic stress disorder (PTSD) and depression.Results: The frequency of PTSD was higher in women with high hurricane exposure (13.8 percent) than women without high hurricane exposure (1.3 percent), with an adjusted odds ratio (aOR) of 16.8 (95% confidence interval: 2.6-106.6) after adjustment for maternal race, age, education, smoking and alcohol use, family income, parity, and other confounders. The frequency of depression was higher in women with high hurricane exposure (32.3 percent) than women without high hurricane exposure (12.3 percent), with an aOR of 3.3 (1.6-7.1). Moreover, the risk of PTSD and depression increased with an increasing number of severe experiences of the hurricane.Conclusions: Pregnant women who had severe hurricane experiences were at a significantly increased risk for PTSD and depression. This information should be useful for screening pregnant women who are at higher risk of developing mental disorders after disaster.


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