Lethal and long-term effects of landfill leachate on Eisenia andrei earthworms: Behavior, reproduction and risk assessment

2021 ◽  
Vol 285 ◽  
pp. 112029
Author(s):  
Sidney Fernandes Sales Junior ◽  
Camille Ferreira Mannarino ◽  
Daniele Maia Bila ◽  
Cláudio Ernesto Taveira Parente ◽  
Fábio Veríssimo Correia ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Landfill Leachate ◽  
Eisenia Andrei ◽  
Long Term Effects

scholarly journals Long-term Effects of Maternal Separation on Anxiety-Like Behavior and Neuroendocrine Parameters in Adult Balb/c Mice

2021 ◽  
Vol 5 ◽  
pp. 247054702110671
Author(s):  
Erika Kestering-Ferreira ◽  
Saulo Gantes Tractenberg ◽  
Francisco Sindermann Lumertz ◽  
Rodrigo Orso ◽  
Kerstin Camile Creutzberg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Assessment ◽  
Life Stress ◽  
Maternal Separation ◽  
Early Life Stress ◽  
The Body ◽  
Long Term Effects ◽  
Mrna Gene ◽  
Composite Scores

Introduction: Disruption of maternal care using maternal separation (MS) models has provided significant evidence of the deleterious long-term effects of early life stress. Several preclinical studies investigating MS showed multiple behavioral and biomolecular alterations. However, there is still conflicting results from MS studies, which represents a challenge for reliability and replicability of those findings. Objective: To address that, this study was conducted to investigate whether MS would affect anxiety-like behaviors using a battery of classical tasks, as well as central and peripheral stress-related biomarkers. Methods: Male Balb/c mice were exposed to MS from postnatal day (PND) 2 to 14 for 180-min per day. Two independent cohorts were performed to evaluate both baseline and anxiety-like behavior responses to MS at PND60. We performed composite scores to evaluate MS effects on anxiety and risk assessment phenotypes. Also, we assessed mRNA gene expression in the medial pre-frontal cortex (mPFC) of glucocorticoid and mineralocorticoid receptors (GR and MR) using real-time PCR and peripheral corticosterone levels (CORT) to investigate possible neurobiological correlates to anxiety behaviors. Results: We found increased anxiety-like behavior and decreased risk assessment and exploratory behaviors in MS mice. The animals exposed to MS also presented a decrease in MR mRNA expression and higher levels of CORT compared to controls. Conclusions: Our findings reinforce the body of evidence suggesting that long-term MS induces effects on anxiety and risk assessment phenotypes following the exposure to a standardized MS protocol. Moreover, MS affected the expression of MR mRNA and induced significant changes on CORT response. This data highlights that the reprograming MS effects on HPA axis could be mediate by MR gene expression in mPFC and chronic overactivity of peripheral CORT levels.

Thiamethoxam: Long-term effects following honey bee colony-level exposure and implications for risk assessment

2019 ◽  
Vol 654 ◽  
pp. 60-71 ◽  
Author(s):  
Helen Thompson ◽  
Jay Overmyer ◽  
Max Feken ◽  
Natalie Ruddle ◽  
Sarah Vaughan ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Honey Bee ◽  
Long Term Effects ◽  
Bee Colony ◽  
Honey Bee Colony ◽  
Colony Level

Immediate and Long-Term Effects of Novel Odors on Risk Assessment in Mice

1997 ◽  
Vol 61 (4) ◽  
pp. 543-549 ◽  
Author(s):  
Ernest D. Kemble ◽  
Bryan L. Bolwahnn
Keyword(s):  
Risk Assessment ◽  
Long Term Effects

Long-term landfill leachate exposure modulates antioxidant responses and causes cyto-genotoxic effects in Eisenia andrei earthworms

2021 ◽  
pp. 117351
Author(s):  
Sidney Fernandes Sales Junior ◽  
Isabele Campos Costa Amaral ◽  
Camille Ferreira Mannarino ◽  
Rachel Ann Hauser-Davis ◽  
Fábio Veríssimo Correia ◽  
...  
Keyword(s):  
Landfill Leachate ◽  
Eisenia Andrei ◽  
Genotoxic Effects ◽  
Antioxidant Responses

scholarly journals Fertility Risk Assessment and Preservation in Male and Female Prepubertal and Adolescent Cancer Patients

2016 ◽  
Vol 10 ◽  
pp. CMO.S32811 ◽  
Author(s):  
Nikolaos Zavras ◽  
Charalampos Siristatidis ◽  
Aargyris Siatelis ◽  
Aanna Koumarianou
Keyword(s):  
Risk Assessment ◽  
Children And Adolescents ◽  
Cancer Patients ◽  
Treatment Options ◽  
Young Patients ◽  
Long Term Effects ◽  
Patients With Cancer ◽  
Adolescent Cancer ◽  
Gonadal Failure

Cancer represents the second cause of death in prepubertal children and adolescents, although it is currently associated with an overall survival rate of 80%–85%. The annual incidence rate is 186.6 per 1 million children and adolescents aged up to 19 years. Both disease and treatment options are associated with life-altering, long-term effects that require monitoring. Infertility is a common issue, and as such, fertility preservation represents an essential part in the management of young patients with cancer who are at risk of premature gonadal failure. This review deals with the up-to-date available data on fertility risk assessment and preservation strategies that should be addressed prior to antineoplastic therapy in this vulnerable subgroup of cancer patients.

Sign in / Sign up

Export Citation Format

Share Document