Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein

In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling and NLRP3 inflammasome activation.

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Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo

Inflammation Research ◽

10.1007/s00011-014-0750-4 ◽

2014 ◽

Vol 63 (9) ◽

pp. 779-787 ◽

Cited By ~ 19

Author(s):

Soyoung Kwak ◽

Sae-Kwang Ku ◽

Jong-Sup Bae

Keyword(s):

High Glucose ◽

Vascular Inflammation

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Nepeta angustifolia attenuates responses to vascular inflammation in high glucose-induced human umbilical vein endothelial cells through heme oxygenase-1 induction

Journal of Ethnopharmacology ◽

10.1016/j.jep.2018.11.015 ◽

2019 ◽

Vol 231 ◽

pp. 187-196 ◽

Cited By ~ 5

Author(s):

Shan Huang ◽

Zhiming Liu ◽

Haifeng Liu ◽

Dongsung Lee ◽

Jule Wang ◽

...

Keyword(s):

Endothelial Cells ◽

Heme Oxygenase ◽

High Glucose ◽

Umbilical Vein ◽

Vascular Inflammation ◽

Heme Oxygenase 1 ◽

Human Umbilical Vein ◽

Umbilical Vein Endothelial Cells

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Effect ofBuddleja officinalison High-Glucose-Induced Vascular Inflammation in Human Umbilical Vein Endothelial Cells

Experimental Biology and Medicine ◽

10.3181/0710-rm-286 ◽

2008 ◽

Vol 233 (6) ◽

pp. 694-700 ◽

Cited By ~ 25

Author(s):

Yun Jung Lee ◽

Dae Gill Kang ◽

Jin Sook Kim ◽

Ho Sub Lee

Keyword(s):

Endothelial Cells ◽

High Glucose ◽

Umbilical Vein ◽

Vascular Inflammation ◽

Human Umbilical Vein ◽

Umbilical Vein Endothelial Cells

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Trivalent Chromium Supplementation Inhibits Oxidative Stress, Protein Glycosylation, and Vascular Inflammation in High Glucose-Exposed Human Erythrocytes and Monocytes

Oxidative Stress and Disease - Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome ◽

10.1201/9781420043792.ch20 ◽

2007 ◽

pp. 301-313

Author(s):

Sushil Jain

Keyword(s):

Oxidative Stress ◽

High Glucose ◽

Vascular Inflammation ◽

Stress Protein ◽

Trivalent Chromium ◽

Human Erythrocytes ◽

Protein Glycosylation

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Abstract 17293: Hyperglycemia Enhances Pro-Inflammatory Properties of Macrophage-Derived Exosomes to Drive Hematopoiesis in Apolipoprotein E-Deficient Mouse

Circulation ◽

10.1161/circ.142.suppl_3.17293 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Laura Bouchareychas ◽

Phat Duong ◽

Tuan Anh Phu ◽

Eric Alsop ◽

bessie meechoovet ◽

...

Keyword(s):

Bone Marrow ◽

High Glucose ◽

Vascular Inflammation ◽

Cell Communication ◽

Chow Diet ◽

Hematopoietic Progenitors ◽

Inflammatory Signaling ◽

Accelerate Atherosclerosis

Introduction: Macrophage-derived exosomes have emerged as important mediators in cell-to-cell communication by influencing inflammatory signaling and the immune function. Hypothesis: We aimed to explore whether hyperglycemia can enhance intercellular communication between mature macrophages and hematopoietic progenitors via exosomes to promote inflammation and diabetic atherosclerosis. Methods: Bone marrow derived macrophages (BMDM) from C57BL/6 mice were cultured with normal (5.5 mM) or high glucose concentrations (25 mM). Exosomes were isolated by cushioned-density gradient ultracentrifugation method followed by nanoparticle tracking and western blot analysis. Inflammatory properties of high glucose exosomes (BMDM-HG-exo) or normoglycemic exosomes (BMDM-NG-exo) were tested in vitro by exposing them to naïve BMDM. The capacity for BMDM-derived exosomes to alter systemic and vascular inflammation were next tested by infusing 25-30 weeks-old ApoE -/- mice fed a chow diet with exosomes three times a week, for four weeks. Results: Our data show that BMDM-HG-exo can stimulate the expression of inflammatory cytokines and generate reactive oxygen species in recipient cultured BMDM. Furthermore, our findings show that intraperitoneally injected exosomes distribute to numerous organs and tissues including the bone marrow and the spleen. HG-exo enhance the expansion of multipotent and lineage committed hematopoietic progenitors in the spleen, leading to an enhanced atherosclerotic progression. Conclusions: We identify that exosomes derived from cultured BMDM exposed to high glucose have the capacity to exert inflammatory signaling in vitro , and in vivo. Our findings suggest that exosomes produced by macrophages exposed to hyperglycemia could represent an unsuspected source of inflammation to accelerate atherosclerosis in diabetes.

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Enzymatic Extraction, Purification, and Characterization of Polysaccharides from Penthorum chinense Pursh: Natural Antioxidant and Anti-Inflammatory

BioMed Research International ◽

10.1155/2018/3486864 ◽

2018 ◽

Vol 2018 ◽

pp. 1-13 ◽

Cited By ~ 5

Author(s):

Li-mei Lin ◽

Ling-jia Zhao ◽

Jing Deng ◽

Su-hui Xiong ◽

Jie Tang ◽

...

Keyword(s):

Radical Scavenging ◽

Steepest Ascent ◽

Penthorum Chinense Pursh ◽

Ft Ir ◽

Experimental Yield ◽

Burman Design ◽

Anti Inflammatory ◽

Penthorum Chinense ◽

Optimized Conditions ◽

Plackett Burman Design

Penthorum chinense Pursh (PCP) is a kind of functional food or medicine for liver protection. In the present work, Plackett-Burman design, steepest ascent method, and response surface methodology (RSM) were employed to obtain maximum total sugar yield. The experimental yield of 6.91% indicated a close agreement with the predicted yield of 7.00% of the model under optimized conditions. The major polysaccharide fraction (PCPP-1a) from PCPP was purified and identified as acidic polysaccharides with a high content of uronic acid (FT-IR, UV, HPGPC). PCPP had similar monosaccharide profile with PCPP-1a but was rich in galacturonic acid (HPLC). Both of PCPP and PCPP-1a possessed strong hydroxyl radical scavenging, DPPH radical scavenging, and Fe2+ chelating activities. Moreover, they were revealed to show strong anti-inflammatory activities by inhibiting NO, TNF-α, and IL-1β release compared to LPS treatment in RAW264.7 cells. These data suggest that the polysaccharides from PCP could be potential natural products for treating ROS and inflammatory-related diseases.

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