Anti-ulcerogenic effect of methanolic extract of Elaeagnus conferta Roxb. seeds in Wistar rats

2012 ◽

Vol 67 (11-12) ◽

pp. 580-586 ◽

Cited By ~ 1

Author(s):

Mohammad Aslam ◽

Mohammed Ali ◽

Rameshwar Dayal ◽

Kalim Javed

Keyword(s):

Data Analysis ◽

Spectral Data ◽

Chemical Reactions ◽

Wistar Rats ◽

Methanolic Extract ◽

Nephroprotective Activity ◽

Coumarin 1 ◽

Spectral Data Analysis

Phytochemical investigations of the methanolic extract of the fruits of Peucedanum grande C. B. Clarke (Apiaceae) led to the identification of three coumarins and a naphthyl labdanoate diarabinoside characterized as 5-hydroxy-6-isopranyl coumarin (1), 5,6-furanocoumarin (2), 7-methoxy-5,6-furanocoumarin (3), and labdanyl-3α-ol-18-(3’’’-methoxy-2’’’- naphthyl-oate)-3α-L-arabinofuranosyl-(2’→1’’)-α-L-arabinofuranoside (4). The structures of these compounds were identified on the basis of spectral data analysis and chemical reactions. The methanolic extract and 4 showed nephroprotective activity against gentamicininduced nephrotoxicity in Wistar rats.

Download Full-text

Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i1-s.4568 ◽

2021 ◽

Vol 11 (1-s) ◽

pp. 113-116

Author(s):

Dhaval M Patel ◽

Advaita B Patel ◽

Bhumi R Patel ◽

Deepa R Patel ◽

Nishith K Patel

Keyword(s):

Oral Administration ◽

Calcium Oxalate ◽

Analysis Of Variance ◽

Cucumis Melo ◽

Wistar Rats ◽

Renal Excretion ◽

Methanolic Extract ◽

Urinary Oxalate ◽

Calcium Oxalate Urolithiasis ◽

Oxalate Synthesis

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

Download Full-text

Histopathological Studies on the Effects of Chloroform and Methanolic Extracts of Ilex kudingcha in Trypanosoma brucei Infected Albino Wistar Rats

Recent Advances in Biology and Medicine ◽

10.18639/rabm.2018.04.735155 ◽

2018 ◽

Vol 04 ◽

pp. 50

Author(s):

Olajoju. T. Soniran ◽

Kalu. K. Ngele ◽

Christopher. O. Alisa ◽

Damilola. A. Omoboyowa ◽

Nnabude. H. Agu ◽

...

Keyword(s):

Trypanosoma Brucei ◽

Wistar Rats ◽

Methanolic Extract ◽

Phytochemical Analysis ◽

Diminazene Aceturate ◽

Leaf Extracts ◽

Standard Drug ◽

Phytochemical Study ◽

Reference Drug ◽

Histopathological Studies

Histopathological studies of the effects of chloroform and methanolic leaf extracts of Ilex kudingcha in Trypanosoma brucei infected albino wistar rats were investigated. The toxicity and phytochemical study were also carried out using standard protocol. T. brucei infected animals were administered orally with 200 and 400 mg/kg b.w. of the extracts and 3.5 mg/kg b.w. of the standard drug (diminazene aceturate). Results on acute toxicity studies (LD50) revealed no sign of lethality up to the dose of 5,000 mg/kg body weight but the liver and kidney histology of infected animals treated with 5,000 mg/kg b.w. of I. kudingcha extracts were observed to be hepatotoxic and nephrotoxic. The methanol extracts showed appreciably high in vivo anti-trypanosomal activities compared to the reference drug. Histological examination of the organs revealed serious pathological lesions in the liver of the infected animals without treatment (negative control). In the positive control animals (infected animals administered standard drug), mild multifocal aggregate of inflammatory leucocytes was observed. In the other experimental animals, no pathological lesion was observed in the liver, kidney, brain, and heart of infected animals treated with the methanolic extract and combined methanol and chloroform extracts. The effectiveness of the methanolic extract at reducing the lesions caused by the parasite is the same compared with the standard drug. Phytochemical analysis of the plant extracts showed that methanol extract contained appreciable high levels of alkaloids, saponin, tannins, phenol, and glycoside while flavonoid was not detected. Hence, the curative properties of methanolic extract of I. kudingcha as observed in the organs indicate its anti-trypanosomal properties but it should be consumed at minimal doses.

Download Full-text

Evaluation of the efficacy of methanolic extract of Foeniculum vulgare in urolithiasis on Wistar rats

International Journal of Pharmacy Research & Technology ◽

10.31838/ijprt/03.01.03 ◽

2019 ◽

Vol 3 (1) ◽

Keyword(s):

Wistar Rats ◽

Methanolic Extract ◽

Foeniculum Vulgare

Download Full-text

Evaluation of analgesic activity of the methanol extract from the galls of Quercus infectoria alone and as an adjuvant in wistar rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20201521 ◽

2020 ◽

Vol 9 (5) ◽

pp. 701

Author(s):

Abishek P. Raichurkar ◽

Shashikala Gowdara Hanumanth Reddy

Keyword(s):

Analgesic Activity ◽

Wistar Rats ◽

Methanolic Extract ◽

Inflammatory Diseases ◽

Syringic Acid ◽

Tail Flick ◽

Hot Plate ◽

Anti Inflammatory ◽

Group 2 ◽

Quercus Infectoria

Background: Non-steroidal anti-inflammatory drugs and opioids are the most preferred drugs for pain relief. Considering the gastrointestinal toxicity, dependence and other side effects, search for better analgesic drug continues. Quercus infectoria (QI) is from the family Fagaceae. The galls of QI are comprised of tannin (36 to 60%), gallic acid, ellagic acid, and syringic acid. They possess antioxidant, anti-inflammatory, antimicrobial, and anti-diabetic properties. In India, galls of QI have been used for the treatment of toothache, diarrhoea, sore throat and inflammatory diseases as a home remedy. This study was conducted to evaluate the analgesic activity of methanolic extract of galls of QI on wistar rats using tail-flick and Eddy’s hot-plate methods. The objective of the study was to evaluate the analgesic activity of methanolic extract of galls of QI alone and as an adjuvant with tramadol on Wistar rats.Methods: Total of 24 wistar rats were included in the study and divided into 4 groups. They received drugs intra-peritoneally as follows. In group 1, normal saline, in group 2, tramadol, in group 3, methanolic extract of galls of QI and in group 4, tramadol with methanolic extract of galls of QI was available.Results: Methanolic extract of galls of QI produced significant maximal possible analgesia (<0.001) at 30 and 60 minutes in tail-flick method whereas it failed to produce analgesia in hot-plate method during all time intervals.Conclusions: Methanolic extract of galls of QI showed analgesic activity in tail-flick method indicating that its possible mechanism of action is spinally mediated.

Download Full-text