Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

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Urinary oxalate and calcium excretion by dogs and cats diagnosed with calcium oxalate urolithiasis

Veterinary Record ◽

10.1136/vr.101130 ◽

2012 ◽

Vol 171 (25) ◽

pp. 646.1-646 ◽

Cited By ~ 6

Author(s):

J. C. Dijcker ◽

A. Kummeling ◽

E. A. Hagen-Plantinga ◽

W. H. Hendriks

Keyword(s):

Calcium Oxalate ◽

Calcium Excretion ◽

Urinary Oxalate ◽

Calcium Oxalate Urolithiasis

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2225 CARDIOVASCULAR RISK IS INCREASED IN PATIENTS WITH CALCIUM OXALATE UROLITHIASIS AND CORRELATED WITH URINARY OXALATE EXCRETION

The Journal of Urology ◽

10.1016/j.juro.2011.02.2466 ◽

2011 ◽

Vol 185 (4S) ◽

Author(s):

Hasan Aydin ◽

Faruk Yencilek ◽

Ismet Bilger Erihan ◽

Binnur Okan ◽

Kemal Sarica

Keyword(s):

Cardiovascular Risk ◽

Calcium Oxalate ◽

Urinary Oxalate ◽

Calcium Oxalate Urolithiasis ◽

Oxalate Excretion ◽

Urinary Oxalate Excretion

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E63 Cardiovascular risk is increased in patients with calcium oxalate urolithiasis and correlated with urinary oxalate excretion

European Urology Supplements ◽

10.1016/s1569-9056(11)61186-x ◽

2011 ◽

Vol 10 (7) ◽

pp. 475

Author(s):

H. Aydin ◽

F. Yencilek ◽

B. Erihan ◽

B. Okan ◽

K. Sarica

Keyword(s):

Cardiovascular Risk ◽

Calcium Oxalate ◽

Urinary Oxalate ◽

Calcium Oxalate Urolithiasis ◽

Oxalate Excretion ◽

Urinary Oxalate Excretion

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A Methanolic Extract from Cucumis melo Linn. protects against Benign Prostatic Hyperplasia and is Anti-Inflammatory in Male Wistar Rats

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2021.11.019 ◽

2021 ◽

Author(s):

R.S. Rajasree ◽

Sibi P. Ittiyavirah ◽

Punnoth Poonkuzhi Naseef ◽

Mohamed Saheer Kuruniyan ◽

Muhammed Elayadeth-Meethal ◽

...

Keyword(s):

Benign Prostatic Hyperplasia ◽

Cucumis Melo ◽

Wistar Rats ◽

Methanolic Extract ◽

Prostatic Hyperplasia ◽

Male Wistar Rats ◽

Anti Inflammatory

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Acute and subacute toxicity study of the methanolic extract of olea europea.L leaves in Wistar rat

E3S Web of Conferences ◽

10.1051/e3sconf/202131901094 ◽

2021 ◽

Vol 319 ◽

pp. 01094

Author(s):

Ibrahim Hinad ◽

Youssef S’hih ◽

Radia El Gui ◽

Aboubaker Elhessni ◽

Abdelhalim Mesfioui ◽

...

Keyword(s):

Body Weight ◽

Oral Administration ◽

Wistar Rats ◽

Methanolic Extract ◽

Histopathological Examination ◽

Hematological Parameters ◽

Wistar Rat ◽

The Body ◽

Olive Leaves ◽

Subacute Toxicity

Olea europea.L (olive tree) is a plant widely used in the world. Its leaves have an extensive use in traditional herbal medicine to prevent and/or treat several diseases especially in Mediterranean regions. Despite this, research into the study of its toxicity is very limited in the literature. For this, this study aims to study the acute and subacute toxicity of methanolic extract olive leaves in Wistar rats. To study acute toxicity, four dose levels (50,300,2000 and 5000 mg/kg body weight) were tested by single oral administration to Wistar rats. The subacute toxicity for 28 days was conducted by daily oral administration of methanolic extract of olive leaves at doses 1000,2000 and 3000 mg/kg in rats Wistar. After fourteen days of the administration of escalating doses, no deaths were recorded in the animals and no clinically detectable signs were observed. The results of subacute toxicity showed that the body weight of rats was not significantly changed by administration of methanolic extract of olive leaves. Monitoring of the behavior of the rats during the study showed the appearance of some manifestations of tremor, agitation and diarrhea in rats treated with the dose of 3000mg/kg. Grosse examination of the kidneys and liver revealed no changes in those organs and histopathological examination showed congestion and inflammation of the fat in rats treated with the dose of 3000mg/kg. the hematological profile showed no significant changes of the measured hematological parameters. Olive leaves should be used with care and caution since its methanolic extract caused some signs of toxicity and may affect the liver at repeated dose. however, more studies are needed to verify and clarify the toxic aspect of olea europea.L leaves.

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