Cangma Huadu granules, a new drug with great potential to treat coronavirus and influenza infections, exert its efficacy through anti-inflammatory and immune regulation

: In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine-derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

Download Full-text

A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?

PPAR Research ◽

10.1155/2012/128068 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Barrie J. Anthony ◽

Jeremy T. Allen ◽

Yuesheng S. Li ◽

Donald P. McManus

Keyword(s):

Immune Response ◽

Immune Regulation ◽

Alternative Activation ◽

Peroxisome Proliferator ◽

Activated Macrophages ◽

Th2 Response ◽

Blood Flukes ◽

Helminth Infections ◽

Anti Inflammatory ◽

Peroxisome Proliferator Activated Receptors

Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease.

Download Full-text

Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation

Pharmacological Reports ◽

10.1016/s1734-1140(11)70619-3 ◽

2011 ◽

Vol 63 (4) ◽

pp. 1029-1039 ◽

Cited By ~ 10

Author(s):

Aline C. Brando Lima ◽

Alexandre L. Machado ◽

Patrícia Simon ◽

Moisés M. Cavalcante ◽

Daniele C. Rezende ◽

...

Keyword(s):

Experimental Model ◽

P38 Mapk ◽

Lung Inflammation ◽

Drug Candidate ◽

Acute Lung Inflammation ◽

New Drug ◽

Anti Inflammatory ◽

P38 Mapk Inhibitor ◽

Mapk Inhibitor

Download Full-text

Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells

Frontiers in Immunology ◽

10.3389/fimmu.2021.726909 ◽

2021 ◽

Vol 12 ◽

Author(s):

Lu Wang ◽

Yun Li ◽

Moyan Xu ◽

Zihui Deng ◽

Yan Zhao ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Immune Regulation ◽

Inflammatory Responses ◽

Inflammatory Factors ◽

Acquired Immunity ◽

The Novel ◽

Disease Exacerbation ◽

Therapeutic Mechanism ◽

Anti Inflammatory

Mesenchymal stem cells (MSCs) have been widely used in preclinical and clinical trials for various diseases and have shown great potential in the treatment of sepsis and coronavirus disease (COVID-19). Inflammatory factors play vital roles in the pathogenesis of diseases. The interaction between inflammatory factors is extremely complex. Once the dynamics of inflammatory factors are unbalanced, inflammatory responses and cytokine storm syndrome develop, leading to disease exacerbation and even death. Stem cells have become ideal candidates for the treatment of such diseases due to their immunosuppressive and anti-inflammatory properties. However, the mechanisms by which stem cells affect inflammation and immune regulation are still unclear. This article discusses the therapeutic mechanism and potential value of MSCs in the treatment of sepsis and the novel COVID-19, outlines how MSCs mediate innate and acquired immunity at both the cellular and molecular levels, and described the anti-inflammatory mechanisms and related molecular pathways. Finally, we review the safety and efficacy of stem cell therapy in these two diseases at the preclinical and clinical levels.

Download Full-text