scholarly journals Histidine-rich glycoprotein functions as a dual regulator of neutrophil activity in horses

2021 ◽  
pp. 103620
Author(s):  
Ryo Muko ◽  
Hiroshi Matsuda ◽  
Masa-aki Oikawa ◽  
Taekyun Shin ◽  
Kenshiro Matsuda ◽  
...  
Keyword(s):  
Neutrophil Activity ◽  
Dual Regulator

Features of the oxidative status in patients with lupus nephritis

2020 ◽  
Vol 24 (1) ◽  
pp. 39-44
Author(s):  
E. V. Smirnova ◽  
E. V. Proskurnina ◽  
T. N. Krasnova
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Lupus Nephritis ◽  
Blood Plasma ◽  
Respiratory Burst ◽  
Oxidative Status ◽  
Free Radical Production ◽  
Radical Production ◽  
Neutrophil Activity ◽  
Kidney Involvement

BACKGROUND. Oxidative status impairment plays a significant role in the pathogenesis of SLE and lupus nephritis (LN). The data about oxidative status in this disease are incomplete, that’s why it’s necessary to use a new approach to study it. THE AIM: To study oxidative status in SLE patients with kidney involvement. PATIENTS AND METHODS:53 patients with SLE were included in this prospective study, among them 40 patients with different severity of kidney involvement, control group were 87 healthy donors. Oxidative stress parameters were measured: antioxidant activity (AOA) of blood plasma and parameters, characterizing the state of the main source of reactive oxygen species (ROS) – neutrophils, more specifically: specific spontaneous neutrophil activity, specific stimulated activity (peak and integral), coefficient of respiratory burst attenuation, representing the rate of free radical production decrease after stimulation, the higher the value of this parameter, the slower is free radical production decrease. RESULTS. It was shown elevation of neutrophil free radical-producing activity parameters and elevation of blood plasma AOA in patients with LN, comparing to healthy controls. Immunosuppressive therapy with glucocorticosteroids (GCS) and cytostatics (CS) increased blood plasma AOA comparing to monotherapy with GCS. A correlation between oxidative status impairment and intensity of inflammatory reactions was found: correlation of respiratory burst attenuation coefficient with blood sedimentation rate was shown. Reduction of spontaneous free radical-producing neutrophil activity was found in LN patients with NS, which might be the result of neutrophil functional activity attenuation in high disease activity. CONCLUSION. The increased free radical-producing neutrophil activity was shown, which might be the cause of oxidative stress in SLE with LN. It seems warranted investigation of these parameters in samples of larger volume to search targets aimed at neutrophils. The necessity of antioxidant therapy in patients with SLE seems doubtful, as they show significant increase of blood plasma AOA, which might result from compensatory reaction of human organism to oxidative stress and therapy with GCS and CS.

Possible role of a dual regulator of neuroinflammation and autophagy in a simulated space environment

2021 ◽  
Author(s):  
Shicong Zhao ◽  
Sizhu Pei ◽  
Ailu Wang ◽  
Yu Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Space Environment ◽  
Dual Regulator

scholarly journals Parcs Is a Dual Regulator of Cell Proliferation and Apaf-1 Function

2008 ◽  
Vol 283 (36) ◽  
pp. 24400-24405 ◽  
Author(s):  
Roberto Sanchez-Olea ◽  
Sara Ortiz ◽  
Odmara Barreto ◽  
Qing Yang ◽  
Chi-jie Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dual Regulator

Neutrophil activity assessed using a novel serological marker of human neutrophil elastase degraded calprotectin is elevated in patients with COPD or IPF

2021 ◽  
Author(s):  
Annika Hummersgaard Hansen ◽  
Joachim Høg Mortensen ◽  
Sarah Rank Rønnow ◽  
Morten Karsdal ◽  
Anne-Christine Bay-Jensen ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Serological Marker ◽  
Human Neutrophil Elastase ◽  
Neutrophil Activity

scholarly journals Skeletal muscle reperfusion injury is mediated by neutrophils and the complement membrane attack complex

1999 ◽  
Vol 277 (6) ◽  
pp. C1263-C1268 ◽  
Author(s):  
Constantinos Kyriakides ◽  
William Austen ◽  
Yong Wang ◽  
Joanne Favuzza ◽  
Lester Kobzik ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Membrane Attack Complex ◽  
Wild Type ◽  
Complement Components ◽  
Neutrophil Activity ◽  
Deficient Mice ◽  
Terminal Complement

The relative inflammatory roles of neutrophils, selectins, and terminal complement components are investigated in this study of skeletal muscle reperfusion injury. Mice underwent 2 h of hindlimb ischemia followed by 3 h of reperfusion. The role of neutrophils was defined by immunodepletion, which reduced injury by 38%, as did anti-selectin therapy with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin (Ig) fusion protein. Injury in C5-deficient and soluble complement receptor type 1-treated wild-type mice was 48% less than that of untreated wild-type animals. Injury was restored in C5-deficient mice reconstituted with wild-type serum, indicating the effector role of C5–9. Neutropenic C5-deficient animals showed additive reduction in injuries (71%), which was lower than C5-deficient neutrophil-replete mice, indicating neutrophil activity without C5a. Hindlimb histological injury was worse in ischemic wild-type and C5-deficient animals reconstituted with wild-type serum. In conclusion, the membrane attack complex and neutrophils act additively to mediate skeletal muscle reperfusion injury. Neutrophil activity is independent of C5a but is dependent on selectin-mediated adhesion.

scholarly journals Humoral Factors From Musculoskeletal Polytrauma Patients Impair Antibacterial Responses Of Neutrophils In vitro

2019 ◽  
Vol 4 (6) ◽  
pp. 280-284
Author(s):  
Aikaterini Stylianaki ◽  
Barbara Stanic ◽  
Mario Morgenstern ◽  
Geoff R. Richards ◽  
Fintan T. Moriarty ◽  
...  
Keyword(s):  
Healthy Controls ◽  
Humoral Factors ◽  
Implant Infection ◽  
Neutrophil Activity ◽  
Increased Risk ◽  
Polytrauma Patients

Abstract. Polytrauma is associated with increased risk of sepsis, but the risk for implant infection is less clear. Neutrophil antibacterial responses are significantly reduced in polytrauma patients (n= 9, ISS≥15) for at least 5 days compared to healthy controls. Reduced neutrophil activity could influence implant infection in addition to sepsis.

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