Possible role of a dual regulator of neuroinflammation and autophagy in a simulated space environment

2021 ◽  
Author(s):  
Shicong Zhao ◽  
Sizhu Pei ◽  
Ailu Wang ◽  
Yu Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Space Environment ◽  
Dual Regulator

scholarly journals The Role of Terrestrial and Space Environments in Launch Vehicle Development

2019 ◽  
Author(s):  
Dale L. Johnson ◽  
William W. Vaughan
Keyword(s):  
Engineering Application ◽  
Space Vehicle ◽  
Launch Vehicle ◽  
Space Environment ◽  
Terrestrial Environment ◽  
Aerospace Vehicles ◽  
Vehicle Development ◽  
Design Requirements ◽  
Space Environments

Natural (Terrestrial & Space) Environment (NE) phenomena play a significant role in the design and flight of aerospace vehicles and in the integrity of the associated aerospace systems and structures. Natural environmental design criteria guidelines described here are based on measurements and modeling of atmospheric and climatic phenomena relative to various aerospace vehicle development and mission/operational procedures, and for vehicle launch locations. Both the terrestrial environment (0-90 km altitude) and the space environment (Earth orbital altitudes) parameters and their engineering application philosophy are given with emphasis on launch vehicle-affected terrestrial environment elements. This paper also addresses the basis for the NE guidelines presented, the interpretation of the guidelines, and application to the development of launch or space vehicle design requirements. This paper represents the first of three on this subject.

India’s Anti-Satellite Test: from the Perspective of International Space Law and the Law of Armed Conflict

2021 ◽  
pp. 1-25
Author(s):  
Shakeel Ahmad
Keyword(s):  
International Law ◽  
Outer Space ◽  
Arms Race ◽  
Space Environment ◽  
International Space ◽  
Law Of Armed Conflict ◽  
Space Law ◽  
Effective Role ◽  
Strategic Position

Abstract To enhance their strategic position, some spacefaring States are engaged in exploiting legal lacunae of international space treaties. Consequently, there is an increase of militarization of outer space. As an instance of such activities, an anti-satellite (asat) test by India represents a strategic move to enhance its deterrence capability rather than earnestly adhering to international space law. Such actions can potentially increase the element of uncertainty in international law, particularly the international space law. The pursuit of military strategic interests in space has increased the possibility of an arms race in space. This article argues that asat tests not only violate certain principles of international law but also undermine the efforts for arms control and disarmament in the outer space. In this regard, an effective role of the international community is required to curb the arms race imperative for a safe and sustainable outer space environment.

scholarly journals A View from the Bush: Space, Environment and the Historiography of Science

2009 ◽  
Vol 28 ◽  
pp. 27-37 ◽  
Author(s):  
Matthew Evenden
Keyword(s):  
Environmental Change ◽  
Environmental History ◽  
History Of Science ◽  
Historical Geography ◽  
Space Environment ◽  
Recent Scholarship ◽  
Spatial Approach ◽  
Historiography Of Science ◽  
History Of

Abstract This paper examines the interdisciplinary connections among the history of science, historical geography and environmental history. Four approaches have shaped recent scholarship: a spatial approach developed primarily but not exclusively within the discipline of geography that emphasizes problems of space, place, location and circulation; second, a disciplinary approach which pursues histories of environmental disciplines; third, a science and change approach containing works which emphasize the role of science in environmental change; and fourth an eco-spatial approach which includes studies that seek to engage with and link historiographies of science, environment and spatiality. I argue that these approaches have created new connections between fields that should be fostered and extended.

scholarly journals Research on detection method of leakage rate of rough pumping valve in space environment simulator

2020 ◽  
Vol 198 ◽  
pp. 03015
Author(s):  
Wu Yue ◽  
Guo Qingliang ◽  
Fang Mingyuan ◽  
Sun Juan ◽  
Guo Ziyin ◽  
...  
Keyword(s):  
Detection Method ◽  
High Vacuum ◽  
Leakage Rate ◽  
Space Environment ◽  
Vacuum System ◽  
Pumping System ◽  
Vacuum Degree ◽  
Valve Leakage

As an important part of the vacuum system in the space environment simulator, the rough pumping system reduces the vacuum degree of the container from atmospheric pressure to the pressure of the high vacuum system when the space environment simulator starts up. As the key equipment of the rough pumping system, the rough pumping valve plays the role of isolating the rough pumping system from the environmental simulator, and its leakage rate has a direct impact on the vacuum degree that the space environment simulator can reach. Therefore, it is very important to detect the leakage rate of the rough pumping valve. In this paper, the leakage rate detection method of the rough pumping valve is introduced, including the valve delivery stage and valve installation stage to the simulator stage, in order to provide some basis for the follow-up valve leakage rate detection work

scholarly journals The Role of Environment As Third Teacher Towards The Development Of Educational Space For Dyslexic Children

2019 ◽  
Vol 6 (2) ◽  
pp. 51-62
Author(s):  
Alice Sabrina Ismail ◽  
Nur Syaza Zureena Zulkurnain
Keyword(s):  
Learning Disability ◽  
Visual Cues ◽  
Well Being ◽  
Research Strategy ◽  
Space Environment ◽  
Learning Space ◽  
Space Design ◽  
Design Attributes ◽  
Physical Elements

Educational space that responds towards disable learning student needs is vital for a conducive learning environment. This paper explores on learning spaces for disable children namely the dyslexic in reference to the role of environment as the third teacher towards designing an appropriate educational space to fulfil their needs. Past literature on dyslexia in Malaysia much focuses on the pedagogy and teaching methods rather than discusses the issue of providing better learning space design that caters to the need of dyslexic children towards their psychological well-being. To conduct this study, the qualitative method involving case study as research strategy is used to establish the appropriate learning space design attributes for the dyslexic children. Data sources for this study are obtained from direct observation on three selected case studies of prominent learning disability school found in the global context. There are two key factors that contributed in the learning process and development of learning disability student namely the dyslexic children. These are the non-physical elements comprises of visual cues, auditory, tactile and kinaesthetic approaches as well as physical elements encompasses of density and size including spatial layout arrangement. Findings of the study are in the form of established referential guideline design to inform future designers, builders, education providers and related authority on how to build a conducive learning space environment for the dyslexic children. This is vital in improving the quality of public education infrastructure for dyslexic students in the Malaysian context towards their betterment in the future. 

scholarly journals Emerging Role of Exosomal Long Non-coding RNAs in Spaceflight-Associated Risks in Astronauts

2022 ◽  
Vol 12 ◽  
Author(s):  
Malik Bisserier ◽  
Nathaniel Saffran ◽  
Agnieszka Brojakowska ◽  
Aimy Sebastian ◽  
Angela Clare Evans ◽  
...  
Keyword(s):  
Rna Splicing ◽  
Potential Role ◽  
Space Environment ◽  
Non Coding Rna ◽  
Peripheral Blood Plasma ◽  
Non Coding Rnas ◽  
Associated Risk Factors ◽  
And Function ◽  
Long Non Coding Rna

During spaceflight, astronauts are exposed to multiple unique environmental factors, particularly microgravity and ionizing radiation, that can cause a range of harmful health consequences. Over the past decades, increasing evidence demonstrates that the space environment can induce changes in gene expression and RNA processing. Long non-coding RNA (lncRNA) represent an emerging area of focus in molecular biology as they modulate chromatin structure and function, the transcription of neighboring genes, and affect RNA splicing, stability, and translation. They have been implicated in cancer development and associated with diverse cardiovascular conditions and associated risk factors. However, their role on astronauts’ health after spaceflight remains poorly understood. In this perspective article, we provide new insights into the potential role of exosomal lncRNA after spaceflight. We analyzed the transcriptional profile of exosomes isolated from peripheral blood plasma of three astronauts who flew on various Shuttle missions between 1998–2001 by RNA-sequencing. Computational analysis of the transcriptome of these exosomes identified 27 differentially expressed lncRNAs with a Log2 fold change, with molecular, cellular, and clinical implications.

Design Light Environment Dining Space

2014 ◽  
Vol 716-717 ◽  
pp. 529-532
Author(s):  
Yan Chun Xing ◽  
Yan Zong
Keyword(s):  
Environmental Design ◽  
Light Environment ◽  
Space Environment ◽  
Environment Design ◽  
Basic Law

Light dining space environment on the quality of environmental design plays an important role in the decision, the paper mainly from three aspects of light environment design a study. Through research and analysis, combining the characteristics of dining space, the lights in the dining space to explore the role of trying to find the lights applied to the basic law of the space environment.

scholarly journals The Role of CIS in the U-space Environment

2020 ◽  
Vol 8 (2) ◽  
pp. 6-10
Author(s):  
Adam Kleczatský ◽  
Šárka Hulínská ◽  
Jakub Kraus
Keyword(s):  
Space Environment

scholarly journals The Two-step Forbush Decrease: A Tale of Two Substructures Modulating Galactic Cosmic Rays within Coronal Mass Ejections

2021 ◽  
Vol 922 (2) ◽  
pp. 216
Author(s):  
Miho Janvier ◽  
Pascal Démoulin ◽  
Jingnan Guo ◽  
Sergio Dasso ◽  
Florian Regnault ◽  
...  
Keyword(s):  
Cosmic Rays ◽  
Coronal Mass Ejections ◽  
Forbush Decrease ◽  
Recovery Phase ◽  
Galactic Cosmic Rays ◽  
Space Environment ◽  
Interplanetary Coronal Mass Ejections ◽  
Superposed Epoch Analysis ◽  
Epoch Analysis

Abstract Interplanetary coronal mass ejections (ICMEs) are known to modify the structure of the solar wind as well as interact with the space environment of planetary systems. Their large magnetic structures have been shown to interact with galactic cosmic rays (GCRs), leading to the Forbush decrease (FD) phenomenon. We revisit in the present article the 17 yr of Advanced Composition Explorer spacecraft ICME detection along with two neutron monitors (McMurdo and Oulu) with a superposed epoch analysis to further analyze the role of the magnetic ejecta in driving FDs. We investigate in the following the role of the sheath and the magnetic ejecta in driving FDs, and we further show that for ICMEs without a sheath, a magnetic ejecta only is able to drive significant FDs of comparable intensities. Furthermore, a comparison of samples with and without a sheath with similar speed profiles enable us to show that the magnetic field intensity, rather than its fluctuations, is the main driver for the FD. Finally, the recovery phase of the FD for isolated magnetic ejecta shows an anisotropy in the level of the GCRs. We relate this finding at 1 au to the gradient of the GCR flux found at different heliospheric distances from several interplanetary missions.

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