scholarly journals Coconut kernel protein in diet protects the heart by beneficially modulating endothelial nitric oxide synthase, tumor necrosis factor-alpha, and nuclear factor-kappaB expressions in experimental myocardial infarction

2013 ◽  
Vol 21 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Suganthi Remya ◽  
Anitha Madhusoodhanan Chikku ◽  
Raveendran Saraswathy Renjith ◽  
Sakunthala Arunima ◽  
Thankappan Rajamohan
Keyword(s):  
Endothelial Nitric Oxide Synthase ◽  
Tumor Necrosis ◽  
Experimental Myocardial Infarction ◽  
Nuclear Factor ◽  
Necrosis Factor Alpha ◽  
Coconut Kernel ◽  
Factor Alpha ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Necrosis Factor

scholarly journals Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha.

1997 ◽  
Vol 17 (10) ◽  
pp. 5719-5726 ◽  
Author(s):  
J Alonso ◽  
L Sánchez de Miguel ◽  
M Montón ◽  
S Casado ◽  
A López-Farré
Keyword(s):  
Endothelial Nitric Oxide Synthase ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Cytosolic Proteins ◽  
Enos Mrna ◽  
Factor Alpha ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Necrosis Factor

Changes in endothelial nitric oxide synthase (eNOS) expression may be involved in the endothelium-dependent vasorelaxation dysfunction associated with several vascular diseases. In the present work, we demonstrate that eNOS mRNA contains a previously undescribed cis element in the 3' untranslated region (3' UTR). A U+C-rich segment in the 3' UTR is critical in complex formation with bovine aortic endothelial cell cytosolic proteins. Tumor necrosis factor alpha (TNF-alpha), which destabilizes eNOS mRNA, increased the binding activity of the cytosolic proteins in a time-dependent manner. These data suggest that endothelial cytosolic proteins bind to the 3' UTR of eNOS mRNA. These proteins may play a role in TNF-alpha-induced eNOS mRNA destabilization.

The Role of Nuclear Factor-kappaB and Melanogenesis in Tumor Necrosis Factor-Alpha-Induced Apoptosis of Normal Human Melanocytes

2002 ◽  
Vol 15 (5) ◽  
pp. 321-329 ◽  
Author(s):  
Jing Shang ◽  
Jürgen Eberle ◽  
Christoph C. Geilen ◽  
Amir M. Hossini ◽  
Lothar F. Fecker ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Necrosis Factor Alpha ◽  
Human Melanocytes ◽  
Normal Human ◽  
Factor Alpha ◽  
Induced Apoptosis ◽  
Necrosis Factor
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