Early stage hepatocellular carcinoma in the elderly: A SEER database analysis

2017 ◽  
Vol 8 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Hani Oweira ◽  
Ulf Petrausch ◽  
Daniel Helbling ◽  
Jan Schmidt ◽  
Meinrad Mannhart ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Stage ◽  
The Elderly ◽  
Seer Database ◽  
Database Analysis

The role of surgical resection for hepatocellular carcinoma in octogenarians: A population-based analysis.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 202-202
Author(s):  
Takintope Akinbiyi ◽  
Atuhani S. Burnett ◽  
Philip Ernst ◽  
Marisa Cevasco ◽  
Donald A. McCain ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Survival Benefit ◽  
The Elderly ◽  
Population Based ◽  
Seer Database ◽  
Significant Difference ◽  
Disease Stages ◽  
The Impact

202 Background: Hepatocellular carcinoma (HCC) is a significant source of morbidity and mortality amongst the elderly population. In appropriately selected patients, surgery is known to confer a survival advantage. Octagenarians, however, given their remaining life expectancy may receive limited benefit from surgery. Nevertheless, insufficient information is available in the literature on the survival benefit of surgery in octagenarians with HCC. Methods: Octogenarians with HCC were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 1998 and 2009. We evaluated patients who underwent surgical resection and those that declined to assess the impact surgery has on overall survival in this population. Results: A total of 8,614 with HCC were identified in the SEER database, of which surgery was recommended for 3,529 (41%). A total of 1,002 patients (28%) underwent surgery and 2,497 (71%) declined. Although there was a trend towards improved survival in the surgery group (7.91 months) vs the non-surgical group (7.03 months), there was no statistically significant difference in survival between the two groups (p = 0.09). Conclusions: Our study demonstrates that octagenarians as a whole do not experience a survival benefit from surgical resection for HCC. Subgroup analysis, however, may ultimately identify benefit in specific disease stages or patients with fewer comorbidities.

Treatment Patterns and Outcomes in Early-stage Hodgkin Lymphoma in the Elderly: A National Cancer Database Analysis

2017 ◽  
Vol 17 (12) ◽  
pp. 812-818 ◽  
Author(s):  
Gaurav Goyal ◽  
Edward B. Maldonado ◽  
Tiffany J. Fan ◽  
Arun Kanmanthareddy ◽  
Peter T. Silberstein ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Early Stage ◽  
The Elderly ◽  
Treatment Patterns ◽  
National Cancer Database ◽  
Database Analysis

Early-stage non-small cell lung cancer: A SEER database analysis.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e17501-e17501
Author(s):  
A. K. Ganti ◽  
V. Shostrom ◽  
K. M. Islam ◽  
A. S. Marr ◽  
L. Smith ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Seer Database ◽  
Small Cell Lung ◽  
Database Analysis

scholarly journals Neuroblastoma of the elderly, an oncologist’s nightmare: case presentation, literature review and SEER database analysis

2014 ◽  
Vol 3 (1) ◽  
pp. 20 ◽  
Author(s):  
Elisa Rogowitz ◽  
Hani M Babiker ◽  
Mohammed Kanaan ◽  
Rebecca A Millius ◽  
Q Ringenberg ◽  
...  
Keyword(s):  
Literature Review ◽  
The Elderly ◽  
Seer Database ◽  
Database Analysis ◽  
Case Presentation

scholarly journals Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophagus Cancer Patients after Surgery: A SEER Database Analysis

2021 ◽  
Author(s):  
Xinrong Li ◽  
Jin Zhang ◽  
Junquan Zhu ◽  
Kaibo Guo ◽  
Yong Guo
Keyword(s):  
The Elderly ◽  
Potential Effect ◽  
Seer Database ◽  
Database Analysis ◽  
Large Tumor ◽  
Large Tumor Size ◽  
Esophagus Cancer ◽  
Elder Patients ◽  
Poor Differentiation ◽  
Probability Of Cancer

Abstract BackgroundEsophagus cancer (EC) is a common and lethal carcinoma, however, the effectiveness and feasibility of the conventional treatments for the elderly patients with surgery have not been discussed fully. The purpose of the current study is to discuss the potential effect of chemotherapy and radiotherapy on the prognosis.ResultsBy PSM, chemotherapy (sHR: 0.588, 95%CI: 0.453-0.763, P<0.001) and radiotherapy (sHR: 0.652, 95%CI: 0.513-0.83, P<0.001) were showed a negative correlation to the probability of cancer specific death (CSD). Based on the nomogram, patients with poor differentiation, large tumor size, advanced T-staging, lymphatic metastasis and distant metastasis tended to benefit from chemotherapy (HR: 0.441, 95%CI: 0.364-0.533, P < 0.001) or radiotherapy (HR: 0.539, 95%CI: 0.448-0.649, P < 0.001) to decrease the probabilities of CSD, while no benefit or even harm was showed among the low-risk ones. ConclusionAggressive treatment such as chemotherapy or radiotherapy was considered effective for the selective elder patients with EC.

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