Relative dose intensity and overall treatment time in older patients with cervical cancer treated with concurrent chemoradiotherapy

2020 ◽  
Author(s):  
Rie Nakamura ◽  
Yuko Shimoji ◽  
Tadaharu Nakasone ◽  
Yusuke Taira ◽  
Yoshihisa Arakaki ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Older Patients ◽  
Concurrent Chemoradiotherapy ◽  
Treatment Time ◽  
Dose Intensity ◽  
Relative Dose Intensity ◽  
Overall Treatment Time

Altered Fractionation Schedules in Radiotherapy of Head and Neck Cancer. A Review

1992 ◽  
Vol 78 (5) ◽  
pp. 311-325 ◽  
Author(s):  
Carlo Fallai ◽  
Patrizia Olmi
Keyword(s):  
Total Dose ◽  
Head And Neck ◽  
Local Control ◽  
Randomized Trials ◽  
Treatment Time ◽  
Dose Intensity ◽  
Field Size ◽  
Overall Treatment Time ◽  
Altered Fractionation ◽  
Improvement In Survival

The authors review the main contributions of international literature to show the current status in clinical trials on unconventional fractionations of the dose in radiotherapy of head and neck cancers. Several clinical (but only a few randomized) trials have been conducted over the last 15 years using hyperfractionated (HF), accelerated (AF) or mixed (HF-AF) schedules. HF schedules have obtained promising results in terms of local control in comparison with conventional fractionation (CF) of the dose. Improvement in survival was also obtained by the random trials of Pinto and Sanchiz, whereas in EORTC trial no. 22791, the improvement in survival rate was only marginal. A significant increase in local control and, less frequently, in survival has been claimed in several studies using HF-AF. Such data still need to be confirmed by a random study, since EORTC trial 22811 showed superimposable results in comparison with CF. Selection of the most suitable cases for altered fractionation schemes is also being studied in ongoing trials of the EORTC (22851) and RTOG (90-03). As regards acute reactions during and after altered fractionation, they are more severe than after CF. Only pure HF with a dose intensity approximately comparable to CF seems to produce similar acute reactions. Several factors have been found to influence the severity of acute mucosal reactions: interfraction interval, overall treatment time, total dose, and field size. As regards late damage, genuine HF schemes seem to cause roughly equivalent late damage in comparison to CF, whereas high-dose intensity schedules have a higher rate of complications. Interfraction interval, overall treatment time, total dose, fraction size and field size can influence the risk of late sequelae. Before altered fractionations can be considered standard therapy, more data are needed, which should be provided by multicentric randomized trials, some of which are already in progress.

The influence of overall treatment time to the efficiency of chemo-radiotherapy for locally advanced cervical cancer

2017 ◽  
Vol 17 (1) ◽  
pp. 124-130
Author(s):  
Ekkasit Tharavichitkul ◽  
Panupat Rugpong ◽  
Nisa Chawapun ◽  
Razvan M. Galalae
Keyword(s):  
Cervical Cancer ◽  
Treatment Time ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Intracavitary Brachytherapy ◽  
Treatment Results ◽  
Overall Treatment Time ◽  
Free Survival ◽  
Significant Difference ◽  
The Mean

AbstractPurposeThis study aims to clarify the influence of overall treatment time (OTT) on the efficiency of combined chemo-radiotherapy in cervical cancer.Material and methodsThis retrospective study enrolled 122 cervical cancer patients who had squamous cell carcinoma and had undergone definitive chemo-radiotherapy from 2009 to 2013. All patients received whole pelvic radiotherapy (WPRT) with the dose of 50 Gy in 25 fractions (with central shielding after 44 Gy) plus intracavitary brachytherapy with the dose of 28 Gy in four fractions. During WPRT, all patients received concurrent chemotherapy with weekly platinum-based regimen. The data of patient characteristics, OTT, treatment results and toxicities were collected and evaluated.ResultsThe mean follow-up time was 36 months. The mean age of patients was 52 years old; 68% of patients were stage IIB related to International Federation of Gynaecology and Obstetrics staging. Pelvic control (PC), distant metastasis-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) rates did not differ significantly in the data-derived cut points of 55·8 and 53 days. No statistically significant difference in treatment results between the two groups of OTT<49 and OTT≥62 days was observed.ConclusionsIn our data-derived cut point, OTT did not influence to PC, DMFS, DFS and OS. The influence of OTT on treatment results may be found in longer periods.

scholarly journals EP-1508 EQD and overall treatment time as prognostic factors in cervical cancer treated with definitive CRT

2019 ◽  
Vol 133 ◽  
pp. S816-S817
Author(s):  
S.I. Perez Alvarez ◽  
G.E. Trejo Durán ◽  
J.C. Rodriguez Rosas ◽  
C.H. Flores Balcazar ◽  
J. Zamora Moreno ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Treatment Time ◽  
Overall Treatment Time

O-042 Overall treatment time during concurrent chemoradiotherapy and outcomes: An RTOG secondary analysis

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S17
Author(s):  
M. Machtay ◽  
S. Swann ◽  
R. Komaki ◽  
W. Sause ◽  
C. Langer ◽  
...  
Keyword(s):  
Concurrent Chemoradiotherapy ◽  
Treatment Time ◽  
Secondary Analysis ◽  
Overall Treatment Time

scholarly journals Study of Side Effects of Patients Receiving Cisplatin in the Treatment of Cervical Cancer by Age Group

2020 ◽  
Vol 43 (4) ◽  
pp. 28-38
Author(s):  
Rachadapan Chaitosa ◽  
Worathida Maskasame
Keyword(s):  
Cervical Cancer ◽  
Side Effects ◽  
Cancer Patients ◽  
Older Patients ◽  
Concurrent Chemoradiotherapy ◽  
Combined Therapy ◽  
Age Groups ◽  
Cervical Cancer Patient ◽  
Younger Patients ◽  
Life Threatening

Background: Cisplatin is one of the options of chemotherapy used to treat cervical cancer. Patient can experience side effects from drugs frequently with many factors as a catalyst including the age of the patient. Objective: To compare the side effects of cervical cancer patients receiving concurrent chemoradiotherapy (Cisplatin) 2 rounds between patients ≤ 60 years and > 60 years. Methods: A retrospective study, 70 cervical cancer patients undergoing concurrent chemoradiotherapy at Ramathibodi Hospital were investigated. Questionnaires about adverse effects were completed by patients at home 7 days after 1st and 2nd courses of combined therapy. The side effects of cervical cancer patients between groups was analyzed. Results: Of 70 patients, there were 47 patients ≤ 60 years and 23 patients > 60 years. After the 1st course, life-threatening side effects occurred in 9 patient’s ≤ 60 years but none occurred in patients > 60 years. Younger patients also had significant more nausea than older patients (P < .05). After the 2nd course, younger patients also had significant more vomiting than older patients (P < .05). The most common side effects for both age groups were fatigue and anorexia respectively. Conclusions: Patients younger than 60 year would experience significantly more symptoms of nausea and vomiting after the 1st and 2nd courses of concurrent chemoradiotherapy.

scholarly journals The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy

Cancer ◽  
2012 ◽  
Vol 119 (2) ◽  
pp. 325-331 ◽  
Author(s):  
Suisui Song ◽  
Sonali Rudra ◽  
Michael D. Hasselle ◽  
Paige L. Dorn ◽  
Loren K. Mell ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Treatment Time ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer ◽  
Effect Of Treatment
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