Cu-induced spermatogenesis disease is related to oxidative stress-mediated germ cell apoptosis and DNA damage

2021 ◽  
pp. 125903
Author(s):  
Hongrui Guo ◽  
Yujuan Ouyang ◽  
Jiaqi Wang ◽  
Hengmin Cui ◽  
Huidan Deng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans

2017 ◽  
Vol 157 (2) ◽  
pp. 510-518 ◽  
Author(s):  
Xinyue You ◽  
Jing Xi ◽  
Yiyi Cao ◽  
Jinfu Zhang ◽  
Yang Luan
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans

2011 ◽  
Vol 18 (7) ◽  
pp. 1140-1149 ◽  
Author(s):  
A J Ross ◽  
M Li ◽  
B Yu ◽  
M X Gao ◽  
W B Derry
Keyword(s):  
Dna Damage ◽  
Germ Cell ◽  
Ubiquitin Ligase ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
C Elegans

scholarly journals Isoflurane impairs oogenesis through germ cell apoptosis in C. elegans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tao Zhang ◽  
Cheng Ni ◽  
Cheng Li ◽  
Pan Lu ◽  
Dan Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Germ Cell ◽  
Fluorescence Imaging ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
C Elegans ◽  
Interaction Studies ◽  
Acetyl Cysteine ◽  
Induced Changes ◽  
And Oxidative Stress

AbstractAnesthetic isoflurane has been reported to induce toxicity. However, the effects of isoflurane on fecundity remain largely unknown. We established a system in C. elegans to investigate the effects of isoflurane on oogenesis. Synchronized L4 stage C. elegans were treated with 7% isoflurane for 4 h. Dead cells, ROS, embryos, and unfertilized eggs laid by hermaphrodites were measured by fluorescence imaging and counting. The C. elegans with losses of ced-3, cep-1, abl-1, male C. elegans, and oxidative stress inhibitor N-acetyl-cysteine were used in the interaction studies. We found that isoflurane decreased the numbers of embryos and unfertilized eggs and increased the levels of dead cells and ROS in C. elegans. The isoflurane-induced impairment of oogenesis was associated with abl-1, ced-3, but not cep-1. N-acetyl-cysteine attenuated the isoflurane-induced impairment of oogenesis in C. elegans. Mating with male C. elegans did not attenuate the isoflurane-induced changes in oogenesis. These findings suggest that isoflurane may impair oogenesis through abl-1- and ced-3-associated, but not cep-1-associated, germ cell apoptosis and oxidative stress, pending further investigation. These studies will promote more research to determine the potential effects of anesthesia on fecundity.

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