scholarly journals Synergistic Effects Induced by a Low Dose of Diesel Particulate Extract and Ultraviolet-A in Caenorhabditis elegans: DNA Damage-Triggered Germ Cell Apoptosis

2014 ◽  
Vol 27 (6) ◽  
pp. 990-1001 ◽  
Author(s):  
Xiaoying Guo ◽  
Po Bian ◽  
Junting Liang ◽  
Yichen Wang ◽  
Luzhi Li ◽  
...  
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Low Dose ◽  
Synergistic Effects ◽  
Ultraviolet A ◽  
Diesel Particulate ◽  
Germ Cell Apoptosis ◽  
Diesel Particulate Extract

scholarly journals 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans

2017 ◽  
Vol 157 (2) ◽  
pp. 510-518 ◽  
Author(s):  
Xinyue You ◽  
Jing Xi ◽  
Yiyi Cao ◽  
Jinfu Zhang ◽  
Yang Luan
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals Silica nanoparticles enhance germ cell apoptosis by inducing reactive oxygen species (ROS) formation in Caenorhabditis elegans

2020 ◽  
Vol 45 (3) ◽  
pp. 117-129 ◽  
Author(s):  
Fangfang Zhang ◽  
Xinyue You ◽  
Tengteng Zhu ◽  
Sumeng Gao ◽  
Yu Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Silica Nanoparticles ◽  
Cell Apoptosis ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Germ Cell Apoptosis ◽  
Ros Formation

scholarly journals Transient Testicular Warming Enhances the Suppressive Effect of Testosterone on Spermatogenesis in Adult Cynomolgus Monkeys (Macaca fascicularis)

2006 ◽  
Vol 91 (2) ◽  
pp. 539-545 ◽  
Author(s):  
Yanhe Lue ◽  
Christina Wang ◽  
Yi-Xun Liu ◽  
Amiya P. Sinha Hikim ◽  
Xue-Sen Zhang ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Synergistic Effects ◽  
Recovery Period ◽  
Heat Exposure ◽  
Suppressive Effect ◽  
Controlled Study ◽  
Cynomolgus Monkeys ◽  
Germ Cell Apoptosis ◽  
Sperm Counts

Context: The context of the study was to examine whether combined testosterone (T) and heat (H) treatment have additive or synergistic effects on suppression of spermatogenesis. Objective: The objective of the study was to determine whether T+H induces a greater suppression of spermatogenesis than either treatment alone in monkeys. Design: The study was a randomized, placebo-controlled study. Setting: The study was conducted at a primate center in China. Participants: The study population was comprised of 32 adult cynomolgus monkeys. Interventions: Groups of eight adult monkeys were treated for 12 wk with: 1) two empty implants (C); 2) two T implants (T); 3) daily testicular heat exposure (43 C for 30 min) for 2 consecutive days (H); or 4) two T implants plus testicular heat exposure (T+H). Treatment was followed by an 8-wk recovery period. Main Outcome Measures: Measures included sperm counts and germ cell apoptosis. Results: Serum T levels were elevated in both the T and T+H groups during treatment but not in the C or H group. Sperm counts were transiently suppressed after heat to 16.4% of baseline at 4 wk and then returned to pretreatment levels. Sperm counts were suppressed slowly after T treatment to nadir of 6.4% of pretreatment levels at 12 wk. T+H rapidly suppressed sperm output as early as 4 wk to 3.9% of pretreatment levels that was maintained throughout treatment. The decreased sperm counts were due to increased germ cell apoptosis in all treatment groups. Sperm counts recovered to the pretreatment levels in all groups by 8 wk after treatment. Conclusion: This proof-of-concept study demonstrates that transient testicular warming enhances and hastens the effect of T implant on the suppression of spermatogenesis in monkeys.

scholarly journals ZnO nanoparticles enhanced germ cell apoptosis in Caenorhabditis elegans , in comparison with ZnCl 2

2016 ◽  
pp. kfw258 ◽  
Author(s):  
Brittany O’Donnell ◽  
Lily Huo ◽  
Joseph R. Polli ◽  
Li Qiu ◽  
David Collier ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Zno Nanoparticles ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis

scholarly journals Ceramide mediates radiation-induced germ cell apoptosis via regulating mitochondria function and MAPK factors in Caenorhabditis elegans

2021 ◽  
Vol 208 ◽  
pp. 111579
Author(s):  
Yaning Yang ◽  
Guangmin Xu ◽  
Yun Xu ◽  
Xiaowen Cheng ◽  
Shengmin Xu ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Radiation Induced

scholarly journals Regulation of Caenorhabditis elegans p53/CEP-1–Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

PLoS Genetics ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. e1002238 ◽  
Author(s):  
Rachael Rutkowski ◽  
Robin Dickinson ◽  
Graeme Stewart ◽  
Ashley Craig ◽  
Marianne Schimpl ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Mapk Signaling ◽  
Germ Cell Apoptosis

scholarly journals The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans

2011 ◽  
Vol 18 (7) ◽  
pp. 1140-1149 ◽  
Author(s):  
A J Ross ◽  
M Li ◽  
B Yu ◽  
M X Gao ◽  
W B Derry
Keyword(s):  
Dna Damage ◽  
Germ Cell ◽  
Ubiquitin Ligase ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
C Elegans
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