Efficacy and safety of colistin for the treatment of infections caused by multidrug-resistant gram-negative bacilli

The rapid spread of multidrug-resistant Gram-negative bacteria in hospital settings all over the world makes a demand for the new options to overcome antimicrobial resistance. Ceftazidime-avibactam is the first approved antibiotic that contains a new beta-lactamase inhibitor with unique properties. This review provides insight into the spectrum of activity, pharmacological characteristics, data on efficacy and safety of ceftazidime-avibactam obtained from the clinical trials and real clinical practice, as well as prospects for further studies and clinical application of this new antimicrobial agent.

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Efficacy and safety of low-dose colistin in the treatment for infections caused by multidrug-resistant gram-negative bacteria

Journal of Clinical Pharmacy and Therapeutics ◽

10.1111/jcpt.12138 ◽

2014 ◽

Vol 39 (3) ◽

pp. 272-276 ◽

Cited By ~ 13

Author(s):

S. T. R. Zaidi ◽

S. Al Omran ◽

A. S. M. Al Aithan ◽

M. Al Sultan

Keyword(s):

Low Dose ◽

Multidrug Resistant ◽

Gram Negative Bacteria ◽

Efficacy And Safety ◽

Gram Negative

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Efficacy and safety of carbapenem-sparing regimens for severely-ill patients with MDR Gram-negative infections in ICU and non-ICU inpatients

10.26226/morressier.56fa7679d462b80296c95271 ◽

2016 ◽

Author(s):

Anna Makina

Keyword(s):

Efficacy And Safety ◽

Gram Negative

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Antibacterial potential and mechanism of action of botanicals and phytochemicals from Stachytarpheta cayennensis (Verbenaceae) against Gram-negative multidrug-resistant phenotypes expressing efflux pumps

Investigational Medicinal Chemistry and Pharmacology ◽

10.31183/imcp.2020.00035 ◽

2020 ◽

Vol 3 (1) ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Laetitia M. Youmbi ◽

Victor Kuete

Keyword(s):

Mechanism Of Action ◽

Efflux Pumps ◽

Multidrug Resistant ◽

Gram Negative ◽

Stachytarpheta Cayennensis ◽

Antibacterial Potential

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Faculty Opinions recommendation of Clinical and economic impact of common multidrug-resistant gram-negative bacilli.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1104201.560202 ◽

2008 ◽

Author(s):

Thomas Dougherty

Keyword(s):

Economic Impact ◽

Multidrug Resistant ◽

Gram Negative

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Faculty Opinions recommendation of In Vitro Activity of the Siderophore Cephalosporin, Cefiderocol, against Carbapenem-Nonsusceptible and Multidrug-Resistant Isolates of Gram-Negative Bacilli Collected Worldwide in 2014 to 2016.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732142063.793555386 ◽

2019 ◽

Author(s):

Richard Watkins

Keyword(s):

Multidrug Resistant ◽

Vitro Activity ◽

In Vitro Activity ◽

Gram Negative

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Faculty Opinions recommendation of Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734998731.793563364 ◽

2019 ◽

Author(s):

Burkhard Tümmler

Keyword(s):

Multidrug Resistant ◽

Gram Negative ◽

Carbapenem Resistant

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Faculty Opinions recommendation of A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737972351.793575624 ◽

2020 ◽

Author(s):

Heath Murray ◽

Hannah Gaimster

Keyword(s):

Broad Spectrum ◽

Multidrug Resistant ◽

Broad Spectrum Antibiotic ◽

Gram Negative

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A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

Chemical Science ◽

10.1039/d1sc03460j ◽

2021 ◽

Author(s):

Xukai Jiang ◽

Nitin A. Patil ◽

Mohammad A. K. Azad ◽

Hasini Wickremasinghe ◽

Heidi Yu ◽

...

Keyword(s):

Public Health ◽

Chemical Biology ◽

Multidrug Resistant ◽

Computational Approach ◽

Gram Negative Bacteria ◽

Global Public Health ◽

Gram Negative ◽

Life Threatening ◽

New Generation ◽

Novel Antibiotics

Multidrug-resistant Gram-negative bacteria have been an urgent threat to global public health. Novel antibiotics are desperately needed to combat these 'superbugs'.

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