scholarly journals 322 The impact of comorbidity identification on outcomes of pyoderma gangrenosum: A retrospective cohort study of previously hospitalized patients

2021 ◽  
Vol 141 (5) ◽  
pp. S57
Author(s):  
M. Ravi ◽  
J. Trinidad ◽  
N. Spaccarelli ◽  
B. Kaffenberger
Keyword(s):  
Cohort Study ◽  
Pyoderma Gangrenosum ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hospitalized Patients ◽  
The Impact

scholarly journals Multiple antimicrobial resistance and outcomes among hospitalized patients with complicated urinary tract infections in the US, 2013–2018: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marya D. Zilberberg ◽  
Brian H. Nathanson ◽  
Kate Sulham ◽  
Andrew F. Shorr
Keyword(s):  
Cohort Study ◽  
Urinary Tract ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Complicated Urinary Tract Infection ◽  
Carbapenem Resistance ◽  
Hospitalized Patients ◽  
Increased Risk ◽  
Tract Infections ◽  
The Impact

Abstract Background Complicated urinary tract infection (cUTI) is common among hospitalized patients. Though carbapenems are an effective treatment in the face of rising resistance, overuse drives carbapenem resistance (CR). We hypothesized that resistance to routinely used antimicrobials is common, and, despite frequent use of carbapenems, associated with an increased risk of inappropriate empiric treatment (IET), which in turn worsens clinical outcomes. Methods We conducted a retrospective cohort study of patients hospitalized with a culture-positive non-CR cUTI. Triple resistance (TR) was defined as resistance to > 3 of the following: 3rd generation cephalosporins, fluoroquinolones, trimethoprim-sulfamethoxazole, fosfomycin, and nitrofurantoin. Multivariable models quantified the impact of TR and inappropriate empiric therapy (IET) on mortality, hospital LOS, and costs. Results Among 23,331 patients with cUTI, 3040 (13.0%) had a TR pathogen. Compared to patients with non-TR, those with TR were more likely male (57.6% vs. 47.7%, p < 0.001), black (17.9% vs. 13.6%, p < 0.001), and in the South (46.3% vs. 41.5%, p < 0.001). Patients with TR had higher chronic (median [IQR] Charlson score 3 [2, 4] vs. 2 [1, 4], p < 0.001) and acute (mechanical ventilation 7.0% vs. 5.0%, p < 0.001; ICU admission 22.3% vs. 18.6%, p < 0.001) disease burden. Despite greater prevalence of empiric carbapenem exposure (43.3% vs. 16.2%, p < 0.001), patient with TR were also more likely to receive IET (19.6% vs. 5.4%, p < 0.001) than those with non-TR. Although mortality was similar between groups, TR added 0.38 (95% CI 0.18, 0.49) days to LOS, and $754 (95% CI $406, $1103) to hospital costs. Both TR and IET impacted the outcomes among cUTI patients whose UTI was not catheter-associated (CAUTI), but had no effect on outcomes in CAUTI. Conclusions TR occurs in 1 in 8 patients hospitalized with cUTI. It is associated with an increase in the risk of IET exposure, as well as a modest attributable prolongation of LOS and increase in total costs, particularly in the setting of non-CAUTI.

1242-P: The Impact of Telehealth on the Management of Diabetes in Rural/Remote North Queensland, Australia: A Retrospective Cohort Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1242-P
Author(s):  
NISHA NANGRANI ◽  
USMAN MALABU ◽  
VENKAT VANGAVETI
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
The Impact
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