Myeloid Adherent Cells Are Involved in Hair Loss in the Alopecia Areata Mouse Model

Introduction: Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. Case Presentation: Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. Discussion: Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

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LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model

Journal of Investigative Dermatology ◽

10.1016/j.jid.2021.07.119 ◽

2021 ◽

Vol 141 (9) ◽

pp. B19

Author(s):

K. Harada ◽

M. Fehrholz ◽

I. Piccini ◽

A. Gilhar ◽

M. Bertolini ◽

...

Keyword(s):

Mouse Model ◽

Alopecia Areata ◽

Hair Follicles ◽

Immune Privilege ◽

Humanized Mouse ◽

Humanized Mouse Model

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Hair growth promoting effect of white wax and policosanol from white wax on the mouse model of testosterone-induced hair loss

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2017.02.036 ◽

2017 ◽

Vol 89 ◽

pp. 438-446 ◽

Cited By ~ 10

Author(s):

Zhan-di Wang ◽

Ying Feng ◽

Li-yi Ma ◽

Xian Li ◽

Wei-feng Ding ◽

...

Keyword(s):

Mouse Model ◽

Hair Loss ◽

Hair Growth ◽

Promoting Effect ◽

Growth Promoting

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“‘You lose your hair, what’s the big deal?’ I was so embarrassed, I was so self-conscious, I was so depressed:” a qualitative interview study to understand the psychosocial burden of alopecia areata

Journal of Patient-Reported Outcomes ◽

10.1186/s41687-020-00240-7 ◽

2020 ◽

Vol 4 (1) ◽

Cited By ~ 1

Author(s):

Natalie V. J. Aldhouse ◽

Helen Kitchen ◽

Sarah Knight ◽

Jake Macey ◽

Fabio P. Nunes ◽

...

Keyword(s):

Hair Loss ◽

Alopecia Areata ◽

Disease Recurrence ◽

Structured Interview ◽

Emotional Impact ◽

Psychosocial Effects ◽

Psychosocial Burden ◽

Qualitative Interview Study ◽

Interview Guide ◽

Expert Clinician

Abstract Background Alopecia areata (AA) is characterized by hair loss that can affect the scalp and body. This study describes the psychosocial burden of AA. Methods Participants diagnosed with AA who had experienced ≥50% scalp hair loss according to the Severity of Alopecia Tool (SALT) were identified by clinicians. A semi-structured interview guide, developed with expert clinician input, included open-ended questions to explore patients’ experiences of living with AA. Data were thematically analyzed to identify concepts and relationships. Results Participants (n = 45, 58% female, mean age 33.3 years [range 15–72], mean SALT 67.2 [range 0–100]) described the AA diagnosis as “devastating”. Both males and females reported emotional and psychological impacts of AA including feeling sad/depressed (n = 21), embarrassed/ashamed (n = 10) and angry/frustrated (n = 3). Patients felt helpless (n = 5) due to the unpredictability of disease recurrence, and anxious (n = 19) about judgement from others. Many patients avoided social situations (n = 18), which impaired relationships and increased isolation. Coping strategies included concealment of hair loss through wigs or make-up, although fear of the displacement of these coverings also caused anxiety and the avoidance of activities that could result in scalp exposure (n = 22). Some patients became more accepting of AA over time, which lessened the emotional impact, though efficacious treatment was still desired. A conceptual framework was developed, and a conceptual model was created to depict the relationship between the physical signs/symptoms and the associated psychosocial effects of AA. Conclusion AA impairs patients’ emotional and psychological wellbeing, relationships and lifestyles. Greater disease awareness and effective treatments are needed.

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COVID-19 Pandemic Impact on Severe Alopecia Areata Patients

Skin Appendage Disorders ◽

10.1159/000520422 ◽

2021 ◽

pp. 1-5

Author(s):

Mehdi Gheisari ◽

Khatere Zahedi ◽

Zohreh Tehranchinia ◽

Hamideh Moravvej ◽

Fahimeh Abdollahimajd ◽

...

Keyword(s):

Dose Reduction ◽

Chronic Stress ◽

Hair Loss ◽

Alopecia Areata ◽

Systemic Therapy ◽

Demographic Data ◽

Severe Infection ◽

Drug Dose ◽

The Other ◽

Protective Measures

Introduction: The pandemic of COVID-19 has several implications for patients with chronic stress-sensitive diseases such as alopecia areata (AA). On the other hand, the vulnerability of AA patients using immunosuppressives to a more severe infection is in the shadow of ambiguity. This teledermatology study aimed to evaluate the course and outcome of AA in patients during this challenging period. Methods: Patients with AA who had previously received systemic therapy included in this study. Information about demographic data, AA history, characteristics, and treatments, hair loss progression, Corona Disease Anxiety Scale (CDAS), adherence to protective measures against the COVID-19, possible infection, and its features obtained via a telephone call. Results: A total of 57 patients participated. The majority (84.2%) of the participants had mild anxiety assessed by CDAS. Two patients (3.5%) had got infected with COVID-19. Twenty-one (36.8%) participants experienced hair loss progression. Hair loss progression correlated with drug dose reduction (OR: 46.09, 95% CI 5.48–387.14, p < 0.001) although it did not influence by the level of anxiety evaluated by the CDAS (p > 0.05). Conclusion: The anxiety perceived by severe AA patients about COVID-19 is mild; however, many experience hair loss progressions owing to their drug dose reduction.

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Pharmaceutico-Analytical study of Karanjadi Taila and its conversion into cream

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.5.5.34 ◽

2020 ◽

Vol 5 (05) ◽

pp. 245-249

Author(s):

Sachin S. Sheth ◽

Gangaprasad R. Asore ◽

Kiran Sudhakar Darade

Keyword(s):

Present Article ◽

Hair Loss ◽

Alopecia Areata ◽

Analytical Study ◽

Chief Complaint ◽

Point Of View ◽

Special Importance ◽

Analytical Results

Karanjadi Taila is medicated oil used in Ayurveda for Indralupta (Alopecia). Indralupta comes under Kshudra Roga which is characterized by loss of hair it can be correlated with Alopecia areata which is having chief complaint of hair loss on body especially on scalp. The aim of the present study is to do physic-chemical standards for the above Taila and its conversion into Karanjadi Taila cream. These two formulations have a special importance from pharmaceutical point of view when compared to usual Tailas or cream. In present article, we are trying to study analytical results of Karanjadi Taila w.s.r. to Karanjadi Taila cream.

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Epidemiological, Clinical, Trichoscopic, and Histopathological Features of Lupus Erythematous Mimicking Alopecia Areata: A Multicenter Retrospective Study

Skin Appendage Disorders ◽

10.1159/000520825 ◽

2022 ◽

pp. 1-5

Author(s):

Daniel Fernandes Melo ◽

Paulo Müller Ramos ◽

Matilde Iorizzo ◽

Caren dos Santos Lima ◽

Erica Baptista Pinto ◽

...

Keyword(s):

Retrospective Study ◽

Early Diagnosis ◽

Hair Loss ◽

Alopecia Areata ◽

Lupus Erythematosus ◽

Medical Records ◽

High Specificity ◽

Histopathological Features ◽

Brown Discoloration ◽

Perivascular Inflammation

Introduction: All types of lupus erythematosus (LE) may cause hair loss. Nonscarring alopecia was correlated with systemic LE, based on its high specificity. Discoid LE can also appear as nonscarring patches in early stages. Patchy alopecia LE-specific may also mimic alopecia areata (AA) – which can co-occur with LE. The distinction is fundamental to early diagnosis and effective treatment. This study aims to analyze clinical, epidemiological, trichoscopic, and histopathological features of patients with patchy LE-specific alopecia, nonscarring type, mimicking AA. Methods: This is a multicentric retrospective study. We reviewed the medical records of patients with a confirmed diagnosis of LE mimicking AA. Results: Ten patients were included (90% female) with a mean age of 45.9 years. Clinically, 60% showed erythema and 70% presented incomplete hair loss. The most common trichoscopic findings were interfollicular arborizing vessels (90%) and scattered brown discoloration (80%). On histopathology, perivascular inflammation (85.7%), peribulbar lymphocytes (85.7%), and dermal pigment incontinence (71.4%) were present in most cases. Discussion/Conclusion: Trichoscopy was found as an essential first step for the patchy alopecia diagnosis, enabling to differentiate LE from AA. Putting it mildly, trichoscopy raises the suspicion that leads to a biopsy, increasing the diagnostic accuracy with better outcome for patients.

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