Screening of commercial cyclic peptide conjugated to HIV-1 Tat peptide as inhibitor of N-terminal heptad repeat glycoprotein-2 ectodomain Ebola virus through in silico analysis

2017 ◽  
Vol 74 ◽  
pp. 366-378 ◽  
Author(s):  
Usman Sumo Friend Tambunan ◽  
Ahmad Husein Alkaff ◽  
Mochammad Arfin Fardiansyah Nasution ◽  
Arli Aditya Parikesit ◽  
Djati Kerami
Keyword(s):  
In Silico ◽  
Ebola Virus ◽  
Cyclic Peptide ◽  
In Silico Analysis ◽  
Heptad Repeat ◽  
Tat Peptide ◽  
Silico Analysis ◽  
Hiv 1

scholarly journals In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive Cells

2016 ◽  
Vol 7 ◽  
Author(s):  
Masaru Yokoyama ◽  
Masako Nomaguchi ◽  
Naoya Doi ◽  
Tadahito Kanda ◽  
Akio Adachi ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Viral Adaptation ◽  
Silico Analysis ◽  
Hiv 1

In silico analysis of molecular interactions between HIV-1 glycoprotein gp120 and TNF receptors

2021 ◽  
pp. 104837
Author(s):  
Neyla Maria Pereira Alves ◽  
Ronald Rodrigues de Moura ◽  
Lucas Coêlho Bernardo ◽  
Almerinda Agrelli ◽  
Ana Sofia Lima Estevão de Oliveira ◽  
...  
Keyword(s):  
Molecular Interactions ◽  
In Silico ◽  
In Silico Analysis ◽  
Tnf Receptors ◽  
Glycoprotein Gp120 ◽  
Silico Analysis ◽  
Hiv 1

scholarly journals In Silico Analysis of Honeybee Venom Protein Interaction with Wild Type and Mutant (A82V + P375S) Ebola Virus Spike Protein

Biologics ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 45-55
Author(s):  
Muhammad Muzammal ◽  
Muzammil Ahmad Khan ◽  
Mohammed Al Mohaini ◽  
Abdulkhaliq J. Alsalman ◽  
Maitham A. Al Hawaj ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Strong Interaction ◽  
In Silico ◽  
Ebola Virus ◽  
In Silico Analysis ◽  
Spike Protein ◽  
Honeybee Venom ◽  
Silico Analysis ◽  
Venom Proteins ◽  
Proteins And Peptides

Venom from different organisms was used in ancient times to treat a wide range of diseases, and to combat a variety of enveloped and non-enveloped viruses. The aim of this in silico research was to investigate the impact of honeybee venom proteins and peptides against Ebola virus. In the current in silico study, different online and offline tools were used. RaptorX (protein 3D modeling) and PatchDock (protein–protein docking) were used as online tools, while Chimera and LigPlot + v2.1 were used for visualizing protein–protein interactions. We screened nine venom proteins and peptides against the normal Ebola virus spike protein and found that melittin, MCD and phospholipase A2 showed a strong interaction. We then screened these peptides and proteins against mutated strains of Ebola virus and found that the enzyme phospholipase A2 showed a strong interaction. According to the findings, phospholipase A2 found in honeybee venom may be an effective source of antiviral therapy against the deadly Ebola virus. Although the antiviral potency of phospholipase A2 has been recorded previously, this is the first in silico analysis of honeybee phospholipase A2 against the Ebola viral spike protein and its more lethal mutant strain.

scholarly journals In silico analysis suggests interaction between Ebola virus and the extracellular matrix

2015 ◽  
Vol 6 ◽  
Author(s):  
Veljko Veljkovic ◽  
Sanja Glisic ◽  
Claude P. Muller ◽  
Matthew Scotch ◽  
Donald R. Branch ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
In Silico ◽  
Ebola Virus ◽  
In Silico Analysis ◽  
Silico Analysis

Experimental and ‘in silico’ analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

2012 ◽  
Vol 20 (15) ◽  
pp. 4838-4847 ◽  
Author(s):  
José L. Domínguez ◽  
Thomas Gossas ◽  
M. Carmen Villaverde ◽  
U. Helena Danielson ◽  
Fredy Sussman
Keyword(s):  
Protease Inhibitor ◽  
Charge State ◽  
In Silico ◽  
In Silico Analysis ◽  
Ionogenic Groups ◽  
Effect Of Ph ◽  
Silico Analysis ◽  
Hiv 1

scholarly journals In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus

Methods ◽  
2011 ◽  
Vol 53 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Leonard Chávez ◽  
Steven Kauder ◽  
Eric Verdin
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Silico Analysis ◽  
Hiv 1
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