Postoperative Peritoneal Dissemination of Ovarian Cancer Cells is not Promoted by Carbon-dioxide Pneumoperitoneum at Low Intraperitoneal Pressure in a Syngenic Mouse Laparoscopic Model with Controlled Respiratory Support: A Pilot Study

2008 ◽  
Vol 15 (3) ◽  
pp. 321-326 ◽  
Author(s):  
Nicolas Bourdel ◽  
Sachiko Matsuzaki ◽  
Jean-Etienne Bazin ◽  
Claude Darcha ◽  
Jean-Luc Pouly ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Ovarian Cancer ◽  
Pilot Study ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Respiratory Support ◽  
Ovarian Cancer Cells ◽  
Intraperitoneal Pressure ◽  
Carbon Dioxide Pneumoperitoneum

scholarly journals Production of IL1-beta by ovarian cancer cells induces mesothelial cell beta1-integrin expression facilitating peritoneal dissemination

2012 ◽  
Vol 5 (1) ◽  
pp. 7 ◽  
Author(s):  
Takafumi Watanabe ◽  
Toshihiro Hashimoto ◽  
Takashi Sugino ◽  
Shu Soeda ◽  
Hiroshi Nishiyama ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Mesothelial Cell ◽  
Ovarian Cancer Cells ◽  
Integrin Expression ◽  
Beta1 Integrin

PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination

2019 ◽  
Vol 442 ◽  
pp. 181-192 ◽  
Author(s):  
Yang Peng ◽  
Hiroaki Kajiyama ◽  
Hong Yuan ◽  
Kae Nakamura ◽  
Masato Yoshihara ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Feedback Loop ◽  
Peritoneal Dissemination ◽  
Ovarian Cancer Cells ◽  
Pai 1

Carbon dioxide pneumoperitoneum, intraperitoneal pressure, and peritoneal tissue hypoxia: a mouse study with controlled respiratory support

2010 ◽  
Vol 24 (11) ◽  
pp. 2871-2880 ◽  
Author(s):  
Sachiko Matsuzaki ◽  
Kris Jardon ◽  
Elodie Maleysson ◽  
Francis D’Arpiany ◽  
Michel Canis ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Tissue Hypoxia ◽  
Respiratory Support ◽  
Intraperitoneal Pressure ◽  
Carbon Dioxide Pneumoperitoneum ◽  
Peritoneal Tissue ◽  
Mouse Study

scholarly journals Downregulation of HtrA1 Promotes Resistance to Anoikis and Peritoneal Dissemination of Ovarian Cancer Cells

2010 ◽  
Vol 70 (8) ◽  
pp. 3109-3118 ◽  
Author(s):  
Xiaoping He ◽  
Takayo Ota ◽  
Peng Liu ◽  
Changqing Su ◽  
Jeremy Chien ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Ovarian Cancer Cells

miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin α5 Expression

2013 ◽  
Vol 182 (5) ◽  
pp. 1876-1889 ◽  
Author(s):  
Chifumi Ohyagi-Hara ◽  
Kenjiro Sawada ◽  
Shoji Kamiura ◽  
Yasuhiko Tomita ◽  
Aki Isobe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Ovarian Cancer Cells ◽  
Integrin Α5

scholarly journals A Possible Inhibitory Role of Sialic Acid on MUC1 in Peritoneal Dissemination of Clear Cell-Type Ovarian Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5962
Author(s):  
Yutaka Tamada ◽  
Hiroyuki Nomura ◽  
Daisuke Aoki ◽  
Tatsuro Irimura
Keyword(s):  
Ovarian Cancer ◽  
Sialic Acid ◽  
Cancer Cells ◽  
Tandem Repeats ◽  
Peritoneal Dissemination ◽  
Abdominal Cavity ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells ◽  
Ovarian Carcinoma Cell Line

The role of sialic acids on MUC1 in peritoneal dissemination of ovarian cancer cells was investigated. A human ovarian carcinoma cell line, ES-2, was transfected with full-length MUC1 containing 22 or 42 tandem repeats. These transfectants were less adherent to monolayers of patient-derived mesothelial cells than ES-2/mock transfectants. When these cells were inoculated into the abdominal cavity of female nude mice, mice that had received the transfectants showed better survival. When the transfectants were mixed with sialidase and injected, the survival was poorer, whereas when they were mixed with N-acetyl-2,3-dehydro-2-deoxyneuraminic acid, a sialidase inhibitor, the survival was significantly prolonged. These behaviors, concerned with peritoneal implantation and dissemination observed in vitro and in vivo, were dependent on the expression of MUC1. Therefore, sialic acid linked to MUC1 in the form, at least in part, of sialyl-T, as shown to be recognized by monoclonal antibody MY.1E12, is responsible for the suppression of adhesion of these cells to mesothelial cells and the suppression of peritoneal implantation and dissemination.

scholarly journals α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 29013-29027 ◽  
Author(s):  
Kuo-Chang Wen ◽  
Pi-Lin Sung ◽  
Shie-Liang Hsieh ◽  
Yu-Ting Chou ◽  
Oscar Kuang-Sheng Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Ovarian Cancer Cells ◽  
Type I
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