Changes in the Expression of Endometrial Receptivity Genes after Hysteroscopic Metroplasty in Infertile Women with Uterine Malformation

2021 ◽  
Vol 28 (11) ◽  
pp. S14-S15
Author(s):  
A. Di Spiezio Sardo ◽  
M.C. De Angelis ◽  
B. Zizolfi ◽  
V. Foreste ◽  
A. Gallo ◽  
...  
Keyword(s):  
Endometrial Receptivity ◽  
Infertile Women ◽  
Uterine Malformation

scholarly journals A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women

Genes ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 574 ◽  
Author(s):  
Kadri Rekker ◽  
Signe Altmäe ◽  
Marina Suhorutshenko ◽  
Maire Peters ◽  
Juan F. Martinez-Blanch ◽  
...  
Keyword(s):  
Embryo Implantation ◽  
Endometrial Receptivity ◽  
Small Rna Sequencing ◽  
Rna Seq ◽  
Recurrent Implantation Failure ◽  
Secretory Phase ◽  
Blood Samples ◽  
Infertile Women ◽  
Secretory Endometrium ◽  
Fertile Women

The endometrium undergoes extensive changes to prepare for embryo implantation and microRNAs (miRNAs) have been described as playing a significant role in the regulation of endometrial receptivity. However, there is no consensus about the miRNAs involved in mid-secretory endometrial functions. We analysed the complete endometrial miRNome from early secretory (pre-receptive) and mid-secretory (receptive) phases from fertile women and from patients with recurrent implantation failure (RIF) to reveal differentially expressed (DE) miRNAs in the mid-secretory endometrium. Furthermore, we investigated whether the overall changes during early to mid-secretory phase transition and with RIF condition could be reflected in blood miRNA profiles. In total, 116 endometrial and 114 matched blood samples collected from two different population cohorts were subjected to small RNA sequencing. Among fertile women, 91 DE miRNAs were identified in the mid-secretory vs. early secretory endometrium, while no differences were found in the corresponding blood samples. The comparison of mid-secretory phase samples between fertile and infertile women revealed 21 DE miRNAs from the endometrium and one from blood samples. Among discovered novel miRNAs, chr2_4401 was validated and showed up-regulation in the mid-secretory endometrium. Besides novel findings, we confirmed the involvement of miR-30 and miR-200 family members in mid-secretory endometrial functions.

005. PREPARING FERTILE SOIL: THE IMPORTANCE OF ENDOMETRIAL RECEPTIVITY

2009 ◽  
Vol 21 (9) ◽  
pp. 4 ◽  
Author(s):  
L. A. Salamonsen
Keyword(s):  
Menstrual Cycle ◽  
Adhesion Molecules ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Present Review ◽  
Altered Expression ◽  
Endometrial Stroma ◽  
Infertile Women ◽  
Glandular Cells ◽  
Secretory Capacity

The human endometrium is receptive for implantation of a blastocyst, for only 4–5 days in each menstrual cycle. Failure of implantation is a major reason for infertility in women, and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Endometrial receptivity requires alterations in the uterine luminal and glandular cells, particularly in terms of their secretory capacity and altered expression of adhesion molecules, along with decidualization of the endometrial stroma, which in women is initiated during the receptive phase, regardless of the presence of a blastocyst. Increased leukocyte numbers are also important. The microenvironments provided by the endometrium during the receptive phase and which support implantation are highly complex and constantly changing. The present review summarizes work from our laboratories and others, regarding these microenvironments, how they impact on receptivity and how they are disturbed in infertile women. Such microenvironments can also be manipulated to provide new contraceptive strategies for women.

scholarly journals Adenomyosis in Infertile Women : A Review

2016 ◽  
Vol 30 (2) ◽  
pp. 105-108
Author(s):  
Shakeela Ishrat ◽  
Parveen Fatima
Keyword(s):  
Magnetic Resonance Imaging ◽  
Transvaginal Ultrasound ◽  
Endometrial Receptivity ◽  
Early Age ◽  
Resonance Imaging ◽  
Infertile Women ◽  
Non Invasive ◽  
Future Pregnancy ◽  
And Function ◽  
Work Up

Adenomyosis is found during infertility work up in many women who delay pregnancy till their late thirties and in some women in their early age. Dysregulation of myometrial architecture and function and altered endometrial receptivity are among the possible mechanisms by which adenomyosis causes infertility. Adenomyosis and endometriosis may have similar pathogenesis as they have frequent association in women. Adenomyosis can be reliably diagnosed in symptomatic infertile women by non invasive means such as transvaginal ultrasound and magnetic resonance imaging as well as hysterosalpingography, hysteroscopy and laparoscopy. Early diagnosis by non-invasive means followed by surgical (adenomyomectomy) or non-surgical (MRgFUS) treatment of focal adenomyosis have promising effect on future pregnancy whereas diffuse severe adenomyosis have poor prognosis.Bangladesh J Obstet Gynaecol, 2015; Vol. 30(2) : 105-108

scholarly journals Using Uterine Biophysical Profile as a Predictor of Endometrial Receptivity and Pregnancy in Stimulated IUI Cycles

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Rawaa Saad Hasan Abunayla ◽  
◽  
Lubna Amer Al-Anbari ◽  
Muayad S, Abood ◽  
Huda A. R. Hussaini ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Assisted Reproductive Technologies ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Endometrial Receptivity ◽  
Infertile Women ◽  
Biophysical Profile ◽  
The Mean

Implantation failure and disorders of endometrial receptivity represent an essential cause of infertility; multiple parameters were needed to predict the uterine receptivity understanding that no sole parameter could predict the same. A score was termed as (Uterine Biophysical Profile) could be utilized as a predictor of endometrial receptivity. To evaluate the predictive potential of Uterine biophysical profile of both endometrial receptivity and pregnancy outcome in infertile women undergoing Intrauterine Insemination (IUI). The current cross-sectional study was conducted in the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies in Al Nahrain University, Baghdad, Iraq from the 1st of Oct. 2018 till 1st of May 2019 involving seventy women of infertile couples with the same inclusion and exclusion criteria. Uterine biophysical profile was evaluated using a doppler ultrasound examination and then a score was calculated and correlated to pregnancy outcome. The mean Uterine Artery Pulsatility Index (UAPI) was significantly lower in women with positive pregnancy in comparison to women with negative pregnancy, 2.10±0.19 versus 2.47±0.65, respectively (P=0.032). Moreover, no women with Pulsatility Index (PI) score (0) succeeded to get pregnant and the higher the score, the higher the rate of pregnancy (P=0.006). Furthermore, Spearman correlation showed significant positive correlation between positive pregnancy outcome and UAPI (r=0.365; P=0.002). The mean total score was significantly higher for pregnant women than in women with negative pregnancy, 18.27±1.33 versus 16.35±2.47, respectively (P=0.005). The cutoff value was >17 with an acceptable accuracy level of 74.2. The sensitivity of that cutoff vale was 80 % and the specificity was 65.5%. Uterine artery pulsatility index and total uterine biophysical score are the principal predictors of positive pregnancy outcomes in infertile women undergoing IUI.

scholarly journals Serum VEGF as a marker of endometrial receptivity in infertile women

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Shipra Paul ◽  
Pooja Jain ◽  
Anita Tuli ◽  
Usha Gupta ◽  
Manjula Jain
Keyword(s):  
Endometrial Receptivity ◽  
Infertile Women

The expression pattern of MUC1 glycoforms and other biomarkers of endometrial receptivity in fertile and infertile women

2005 ◽  
Vol 72 (2) ◽  
pp. 216-229 ◽  
Author(s):  
A.W. Horne ◽  
E.-N. Lalani ◽  
R.A. Margara ◽  
T.A. Ryder ◽  
M.A. Mobberley ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Endometrial Receptivity ◽  
Infertile Women

scholarly journals Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Fangyuan Li ◽  
Hua Lu ◽  
Xinxin Wang ◽  
Qi Zhang ◽  
Qianchen Liu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Pregnancy Rate ◽  
Endometrial Thickness ◽  
Controlled Trial ◽  
Resistance Index ◽  
Endometrial Receptivity ◽  
Controlled Clinical Trial ◽  
Thin Endometrium ◽  
Infertile Women ◽  
Randomized Controlled

Abstract Background Thin endometrium negatively impacts the reproductive function. Current treatments for thin endometrium do not always improve endometrial receptivity. Preliminary evidence suggests that electroacupuncture could have potential therapy for thin endometrium in infertile women. Thus, this randomized controlled trial was designed to test whether electroacupuncture can improve endometrial receptivity in infertile women with thin endometrium. Methods This study is a randomized, single-blinded, controlled, clinical trial. A total of 142 eligible patients will be recruited and randomly assigned to the electroacupuncture (EA) group or the sham electroacupuncture (SEA) group in a 1:1 ratio. Participants will receive 36 sessions over three menstrual cycles (12 weeks in total), with the same acupoint prescription. The primary outcome of this trial is endometrial thickness in the midluteal phase. The secondary outcomes include endometrial pattern, resistance index (RI) and pulsatility index (PI) of bilateral uterine artery and endometrium blood flow, serum estradiol (E2) and progesterone (P), and pregnancy rate. The pregnancy rate will be evaluated during a 6-month follow-up after completion of the trial. All other outcomes will be evaluated before treatment, during the treatment of 1st, 2nd, and 3rd menstrual cycle, and 6 months after treatment. Discussion If the outcome confirms the effectiveness of electroacupuncture for thin endometrium in infertile women, this treatment will be proposed for application in clinical practice. Trial registration Chinese Clinical Trials Registry ChiCTR2000029983. Registered on 18 February 2020

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