Outcomes Using Hysteroscopic Morcellator for Evacuating Products of Conception after Missed Abortion

2021 ◽  
Vol 28 (11) ◽  
pp. S127
Author(s):  
K.J. Sasaki ◽  
C.E Miller
Keyword(s):  
Missed Abortion ◽  
Products Of Conception

scholarly journals THE STUDY OF EFFICACY OF SUBLINGUAL MISOPROSTOL IN TERMINATION OF EARLY PREGNANCY

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Arti Kumari ◽  
Usha Kumari ◽  
Anupama Sinha
Keyword(s):  
Side Effects ◽  
Spontaneous Abortion ◽  
Early Pregnancy ◽  
Gestational Age ◽  
High Efficacy ◽  
Missed Abortion ◽  
Pregnancy Failure ◽  
Products Of Conception ◽  
Early Pregnancy Failure ◽  
Sublingual Misoprostol

Introduction: Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy failure is varied and dose and route are not well established. AIM: To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. Results: Mean gestational age was 7.946+1.2 weeks. Mean induction abortion interval was 18.241+1.2 hours. Women with gestational age six to eight weeks had least mean induction-abortion interval time of 17.38+2.86. Mean dose required was 1560mcg. Efficacy of protocol was 92.85% in achieving complete abortion. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Thus by using a lower dose and appropriate interval between two doses (six hours), the side effects were lessened with high efficacy. Keywords: Efficacy, Missed Abortion, Misoprostol.

Pseudolipomatosis in Endometrial Specimens Does Not Represent Uterine Perforation

2016 ◽  
Vol 25 (1) ◽  
pp. 56-57 ◽  
Author(s):  
Alexis Heller
Keyword(s):  
Adipose Tissue ◽  
Blood Clot ◽  
Uterine Perforation ◽  
Missed Abortion ◽  
Products Of Conception

Background: Specimens of endometrial biopsies can sometimes present with an artifact within blood, composed of optically clear vacuoles mimicking adipose tissue, pseudolipomatosis. This artifact can be mistaken for adipose tissue and lead to an overdiagnosis of uterine perforation. Case: We describe the case of pseudolipomatosis seen within the evacuated products of conception from a missed abortion. Results: Areas of vacuolization in the blood clot mimicked adipose tissue. However, the vacuoles varied in size and did not contain adipocytes. Conclusion: Familiarity with this artifact will lead to avoidance of overdiagnosis of adipose tissue and uterine perforation in curettage specimens.

scholarly journals Effect of assisted reproductive technology on the molecular karyotype of missed abortion tissues

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Gang Li ◽  
Haixia Jin ◽  
Wenbin Niu ◽  
Jiawei Xu ◽  
Yihong Guo ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Snp Array ◽  
Reproductive Technology ◽  
Missed Abortion ◽  
Karyotypic Abnormality ◽  
Products Of Conception ◽  
Significant Difference ◽  
Molecular Karyotype ◽  
Snp Array Analysis ◽  
And Gender

Missed abortion is one of the common complications of assisted reproductive technology (ART). Genetic abnormality is the most important factor. However, the effect of ART on the molecular karyotype of products of conception (POC) remains unknown. We explored the effect of ART on the molecular karyotype of POC in miscarriage. POC were obtained from women undergoing ART. Single nucleotide polymorphism (SNP) microarray was used to analyze the molecular karyotype. A total of 1493 POC were collected for SNP array analysis. The total rate of karyotypic abnormalities was 63.1% (943/1493). The proportion of karyotypic abnormalities was 70.4% (193/416) in >35-year-old group, which was significantly higher than that (60.6%) (343/566) in <30-year-old group and that (60%) (307/511) in the 30–35-year-old group. In natural conception (NC) group, the proportion of karyotypic abnormalities was 64.6% (201/311), whereas in ART group it was 62.7% (742/1182) and, there was no significant difference. The ratio between male and female fetuses was 1:1.13 (698/795). The rate of karyotypic abnormalities in male was 62.9% (439/698) and that in female was 63.4% (504/795), and these values did not differ significantly (P=0.84). Molecular karyotypic abnormality is the most important reason in miscarriage, and female age is a significant factor influencing the karyotypic abnormalities. Comparison with NC, ART, and gender of aborted embryos may not increase the rate of molecular karyotypic abnormality in miscarriage.

scholarly journals MISSED MISCARRIAGE

2016 ◽  
Vol 23 (06) ◽  
pp. 736-740
Author(s):  
Bushra Saeed ◽  
Musrat Akhtar ◽  
Muhammad Akram
Keyword(s):  
Controlled Trial ◽  
First Trimester ◽  
Medical Group ◽  
Missed Abortion ◽  
Safe Alternative ◽  
Medical Termination ◽  
Products Of Conception ◽  
Significant Difference ◽  
The Difference ◽  
Surgical Group

Objectives: The aim of this study was to compare the medical treatment withsurgical evacuation of uterus in the management of first trimester missed miscarriage. StudyDesign: Randomize controlled trial: Place and Duration of Study: The study was conductedin the Obstetrics and Gynecology department civil hospital Bahawalpur from 1st January 20114to 31 December; 2014. Material and Methods: Total 120 patients were included in the studydiagnosed as a case of first trimester missed abortion. Patients were randomly assignedeither medical or surgical group. In the surgical group (controlled group) dilatation and theevacuation was performed. In the medical group misoprostol was used for medical termination.The criteria for success was complete expulsion of products of conception. Results: Therewas no statistically significant difference regarding demographic and clinical characteristicsbetween the two groups .Complete expulsion of the conceptus was less in medical group(83.3%) than the surgical group (88.3%) but the difference was not significant. Almost 16.7%patients in the medical group had failure of expulsion and underwent surgical evacuation.Duration of bleeding after the procedure was 9±2.6 days in surgical group and 12±3.4 inmedical group. Conclusion: Medical termination of first trimester missed miscarriage usingMisoprostol (800mcg initial dose followed by 400mcg 4 hourly 3 doses if need) is an efficaciousand safe alternative to the surgery.

Dual and multiple trisomies: analysis of 38 cases from 13 thousand karyotyped embryos and fetuses

2017 ◽  
pp. 109-115
Author(s):  
N.P. Veropotvelyan ◽  
Keyword(s):  
Prenatal Diagnosis ◽  
High Risk ◽  
Pregnant Women ◽  
Maternal Age ◽  
Chromosomal Abnormalities ◽  
Chorionic Villus ◽  
Primary Group ◽  
Chorionic Villus Sampling ◽  
Missed Abortion ◽  
Reproductive Losses

The study presents data of different authors, as well as its own data on the frequency of multiple trisomies among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of chromosomal abnormalities (CA) in I and II trimesters of gestation. The objective: determining the frequency of occurrence of double (DT) and multiple trisomies (MT) among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of occurrence of HA in I and II trimesters of gestation; establishment of the most common combinations of diesel fuel and the timing of their deaths compared with single regular trisomy; comparative assessment materinskogo age with single, double and multiple trisomies. Patients and methods. During the period from 1997 to 2016, the first (primary) group of products in 1808 the concept of missed abortion (ST) of I trimester was formed from women who live in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions. The average term of the ST was 8±3 weeks. The average age of women was 29±2 years. The second group (control) consisted of 1572 sample product concepts received during medical abortion in women (mostly residents of Krivoy Rog) in the period of 5-11 weeks of pregnancy, the average age was 32 years. The third group was made prenatally karyotyped fruits (n = 9689) pregnant women with high risk of HA of the above regions of Ukraine, directed the Centre to invasive prenatal diagnosis for individual indications: maternal age, changes in the fetus by ultrasound (characteristic malformations and echo markers HA) and high risk of HA on the results of the combined prenatal screening I and II trimesters. From 11 th to 14 th week of pregnancy, chorionic villus sampling was performed (n=1329), with the 16th week – platsentotsentez (n=2240), 18 th and 24 th week – amniocentesis (n=6120). Results. A comparative evaluation of maternal age and the prevalence anembriony among multiple trisomies. Analyzed 13,069 karyotyped embryonic and fetal I-II trimester of which have found 40 cases of multiple trisomies – 31 cases in the group in 1808 missed abortion (2.84% of total HA), 3 cases including 1 572 induced medabortov and 7 cases during 9689 prenatal research (0.51% of HA). Determined to share the double trisomies preembrionalny, fetal, early, middle and late periods of fetal development. Conclusion. There were no significant differences either in terms of destruction of single and multiple trisomies or in maternal age or in fractions anembrionalnyh pregnancies in these groups. Key words: multiple trisomies, double trisomy, missed abortion, prenatal diagnosis.

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