scholarly journals Correlation of virulence genes to clinical manifestations and outcome in patients with Streptococcus dysgalactiae subspecies equisimilis bacteremia

2014 ◽  
Vol 47 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Chia-Ta Tsai ◽  
Chih-Yu Chi ◽  
Cheng-Mao Ho ◽  
Po-Chang Lin ◽  
Chia-Hui Chou ◽  
...  
Keyword(s):  
Virulence Genes ◽  
Clinical Manifestations ◽  
Streptococcus Dysgalactiae ◽  
Streptococcus Dysgalactiae Subspecies Equisimilis

scholarly journals Emergence of a Streptococcus dysgalactiae subspecies equisimilis stG62647-lineage associated with severe clinical manifestations

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Oddvar Oppegaard ◽  
Haima Mylvaganam ◽  
Steinar Skrede ◽  
Paul Christoffer Lindemann ◽  
Bård Reiakvam Kittang
Keyword(s):  
Clinical Manifestations ◽  
Streptococcus Dysgalactiae ◽  
Streptococcus Dysgalactiae Subspecies Equisimilis

Septic Osteoarthritis Due to Streptococcus dysgalactiae Subspecies equisimilis in a Three-Year-Old Girl

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Mesa-del-Castillo B. P. ◽  
Paula Alcaniz Rodiguez ◽  
Ana Blazquez ◽  
Marta Castellon Perez ◽  
Carme Salvador Garcia ◽  
...  
Keyword(s):  
Streptococcus Dysgalactiae ◽  
Streptococcus Dysgalactiae Subspecies Equisimilis ◽  
Septic Osteoarthritis

Yogurt Containing Bioactive Molecules Produced by Lactobacillus acidophilus La-5 Exerts a Protective Effect against Enterohemorrhagic Escherichia coli in Mice

2012 ◽  
Vol 75 (10) ◽  
pp. 1796-1805 ◽  
Author(s):  
MOHAMED ZEINHOM ◽  
ANGELA M. TELLEZ ◽  
VERONIQUE DELCENSERIE ◽  
A. M. EL-KHOLY ◽  
S. H. EL-SHINAWY ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Protective Effect ◽  
Lactobacillus Acidophilus ◽  
Virulence Genes ◽  
Clinical Manifestations ◽  
Enterohemorrhagic Escherichia Coli ◽  
Bioactive Molecules ◽  
Necrosis Factor Alpha ◽  
In Vivo Effects

An active fraction extracted from Lactobacillus acidophilus La5 cell-free spent medium (LAla-5AF) was incorporated in a dairy matrix and tested to assess its antivirulent effect against enterohemorrhagic Escherichia coli (EHEC). Mice in experimental groups were fed for 4 days with yogurt supplemented with LAla-5AF. On the fifth day, mice were challenged with a single dose (107 CFU per mouse) of E. coli O157:H7. The clinical manifestations of the infection were significantly less severe in mice fed the yogurt supplemented with LAla-5AF. EHEC attachment and colonization was attenuated by LAla-5AF. Tumor necrosis factor alpha production was down-regulated, which might indicate a protective effect in the kidney during EHEC infection. To investigate the mechanisms associated with the in vivo effects observed, LAla-5AF was tested by reverse transcription real-time PCR to confirm its effects on the expression of several virulence genes of EHEC O157. The results showed that these fractions were able to down-regulate several virulence genes of EHEC, including stxB2, qseA, luxS, tir, ler, eaeA, and hlyB.

scholarly journals The irp2 and fyuA genes in High Pathogenicity Islands are involved in the pathogenesis of infections caused by avian pathogenic Escherichia coli (APEC)

2016 ◽  
Vol 19 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Jian Tu ◽  
Ting Xue ◽  
Kezong Qi ◽  
Ying Shao ◽  
Boyan Huang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Virulence Genes ◽  
Clinical Manifestations ◽  
Avian Pathogenic Escherichia Coli ◽  
Knock Out ◽  
Bacterial Infectious Disease ◽  
Pathogenic Escherichia Coli ◽  
High Pathogenicity ◽  
Genetic Deletion ◽  
Systemic Infections

Abstract Avian pathogenic Escherichia coli (APEC) is a major bacterial infectious disease that may lead to local or systemic infections in chickens with clinical manifestations. The irp2-fyuA gene cluster has been confirmed to be the main genes involved in the synthesis of HPI. The objective of this study was to determine the influence of the irp2 and fyuA genes in the high pathogenicity island (HPI) of avian pathogenic Escherichia coli (APEC) on its pathogenicity by knocking out these genes. The ΔAE17 (lacking irp2) and ΔΔAE17 (lacking irp2 and fyuA) strains of APEC were constructed. The ΔAE17 and ΔΔAE17 strains showed significantly impaired capacity to adhere onto DF-1 cells. The LD50 results indicated that the virulence of the ΔAE17 and ΔΔAE17 strains was decreased in comparison with that of the AE17 strain. We concluded that the knock-out of the core HPI genes weakened APEC adhesion onto DF-1 cells, inhibited transcription of virulence genes, and reduced pathogenicity in chicks. The effects of genetic deletion of irp2 and fyuA on APEC were more severe than those produced by deletion of irp2 only, indicating that irp2 and fyuA co-regulate APEC pathogenicity.

scholarly journals Meningitis in a Pregnant Woman Caused by Streptococcus dysgalactiae subspecies equisimilis

2013 ◽  
Vol 62 (2) ◽  
pp. 217-219 ◽  
Author(s):  
ROBERT WALTEREIT ◽  
ULRICH HERRLINGER ◽  
MAIK STARK ◽  
STEFAN BORGMANN
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Woman ◽  
Immunocompromised Patients ◽  
Streptococcus Dysgalactiae ◽  
Pathogenic Potential ◽  
First Case ◽  
The Central Nervous System ◽  
Streptococcus Dysgalactiae Subspecies Equisimilis ◽  
The Brain

Infection of the central nervous system by streptococci is known to result in severe bacterial meningitis, however some strains have low pathogenic potential and affect the brain only in immunocompromised patients. Here we report the first case of an otherwise healthy non immunocompromised young adult woman who developed meningitis caused by Streptococcus dysgalactiae subspecies equisimilis. The patient was in the 17th week of her 3rd pregnancy. The course of the disease was quickly remittent under antibiotic treatment.

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