A case of prosthetic joint septic arthritis caused by Gordonia jacobaea

Abstract. Background: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk for infection. This study describes bone and joint infections (BJI) among HSCT recipients.Methods: We reviewed 5861 patients who underwent HSCT at Mayo Clinic, Rochester, MN from January 1, 2005 through January 1, 2015 for study inclusion. BJI was defined as native septic arthritis, prosthetic joint infection, osteomyelitis, and orthopedic implant infection. All adults with BJI after HSCT were included in the analysis.Results: Of 5861 patients, 33 (0.6%) developed BJI. Native joint septic arthritis was the most common BJI occurring in 15/33 (45.4%) patients. Patients were predominantly male (24/33, 72.7%), with median age of 58 (range 20-72) years. BJI was diagnosed a median of 39 (range 1-114) months after allogeneic (14/33, 42.4%) or autologous (19/33, 57.6%) HSCT. Organisms were recovered via tissue (24/27, 88.9%), synovial fluid (13/17, 76.5%), and/or blood cultures (16/25, 64%). Most underwent surgical debridement (23/33, 69.7%). Patients were followed a median of 78.3 months (range 74-119). Therapy was unsuccessful in 4/33 (12.1%), with death related to the underlying BJI in two (50%). Failure occurred a median of 3.4 (0.1-48.5) months from diagnosis. At last follow up, 7/33 (21.2%) patients were alive. Median overall survival was 13 months (0.07-70.6).Conclusion: BJI among HSCT recipients is infrequent. The most common infection is native joint septic arthritis. Pathogens appear similar to patients without HSCT. Treatment involving surgical-medical modalities is successful, with most patients surviving >1 year after BJI.

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Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient

BMJ Case Reports ◽

10.1136/bcr-2020-236396 ◽

2020 ◽

Vol 13 (9) ◽

pp. e236396

Author(s):

Abuzar Ali Asif ◽

Moni Roy ◽

Sharjeel Ahmad

Keyword(s):

Septic Arthritis ◽

Rare Case ◽

Immunocompetent Patient ◽

Next Generation ◽

Ureaplasma Parvum ◽

Urogenital Infections ◽

Joint Infections ◽

Prosthetic Joint ◽

Prosthetic Joint Infections ◽

Diagnostic Modalities

Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma. Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.

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BACTERIAL (SEPTIC) ARTHRITIS AND PROSTHETIC JOINT INFECTION

Rheumatology Science and Practice ◽

10.14412/1995-4484-2017-192-200 ◽

2017 ◽

Vol 55 (2) ◽

pp. 192-200 ◽

Cited By ~ 1

Author(s):

B. S. Belov ◽

S. A. Makarov ◽

E. I. Byalik

Keyword(s):

Septic Arthritis ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Prosthetic Joint

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The difference between native septic arthritis and prosthetic joint infections: A review of literature

Journal of Orthopaedic Surgery ◽

10.1177/2309499019860468 ◽

2019 ◽

Vol 27 (2) ◽

pp. 230949901986046 ◽

Cited By ~ 1

Author(s):

Ramon Lucas Roerdink ◽

Henricus Johannus Theodorus Antoniu Huijbregts ◽

Antoine Willy Tonny van Lieshout ◽

Martijn Dietvorst ◽

Babette Corine van der Zwaard

Keyword(s):

Septic Arthritis ◽

Current Literature ◽

Treatment Strategies ◽

Review Of Literature ◽

Joint Infections ◽

Prosthetic Joint ◽

Prosthetic Joint Infections ◽

The Difference

Current literature occasionally considers septic arthritis in native joints and prosthetic joint infections as equal pathologies. However, significant differences can be identified. The aim of this review of literature is to describe these differences in definitions, pathology, diagnostic workups, treatment strategies, and prognosis.

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Bacterial (septic) arthritis and prosthetic joint infection

Consilium Medicum ◽

10.26442/2075-1753_2016.12.110-116 ◽

2016 ◽

Vol 18 (12) ◽

pp. 110-116 ◽

Cited By ~ 1

Author(s):

B.S. Belov ◽

◽

S.A. Makarov ◽

E.I. Bialik ◽

◽

...

Keyword(s):

Septic Arthritis ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Prosthetic Joint

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Acute Streptococcus mitis Sacroiliitis in a Teenager with Unclear Source of Bacteremia: A Case Report and Literature Review

Case Reports in Infectious Diseases ◽

10.1155/2018/2616787 ◽

2018 ◽

Vol 2018 ◽

pp. 1-3

Author(s):

Fatma Al-Farsi ◽

Ibrahim Al-Busaidi ◽

Khalfan Al-Zeedi

Keyword(s):

Septic Arthritis ◽

Bacterial Endocarditis ◽

Hematogenous Spread ◽

Streptococcus Mitis ◽

Rare Form ◽

Osteoarticular Infections ◽

Prosthetic Joint ◽

Septic Sacroiliitis ◽

Spread Of Infection ◽

Viridans Group Streptococci

Septic arthritis is an orthopedic emergency that is commonly caused by Staphylococcus aureus. Old age, diabetes mellitus, rheumatoid arthritis, prosthetic joint, and recent surgery are the main predisposing risk factors. Most cases of septic arthritis are caused by hematogenous spread of infection. Infectious sacroiliitis is a rare form of septic arthritis which is often clinically challenging to diagnose due its various and nonspecific presentations. Streptococcus mitis belongs to viridans group streptococci (VGS) bacteria, which is a component of body flora that is commonly involved in bacterial endocarditis. VGS in general and S. mitis specifically is an uncommon cause of osteoarticular infections. Here, we report a case of spontaneous Streptococcus mitis bacteremia complicated by septic sacroiliitis in a healthy teenager in the absence of infective endocarditis or a clear source of bacteremia.

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Gonococcal Prosthetic Joint Infection

Journal of Bone and Joint Infection ◽

10.7150/jbji.20791 ◽

2017 ◽

Vol 2 (3) ◽

pp. 160-162 ◽

Cited By ~ 1

Author(s):

Ian Gassiep ◽

Bradley Gilpin ◽

Joel Douglas ◽

David Siebert

Keyword(s):

Septic Arthritis ◽

Antimicrobial Therapy ◽

Prosthetic Joint Infection ◽

Joint Infection ◽

Age Groups ◽

Gonococcal Infection ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Neisseria Gonorrhoea ◽

Prosthetic Joint

Abstract. Neisseria gonorrhoea is a common sexually transmitted infection worldwide. Disseminated gonococcal infection is an infrequent presentation and rarely can be associated with septic arthritis. Incidence of this infection is rising, both internationally and in older age groups. We present the first documented case of N. gonorrhoea prosthetic joint infection which was successfully treated with laparoscopic debridement and antimicrobial therapy.

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Neisseria meningitidis as a Cause of Septic Arthritis: An Unusual Case of Periprosthetic Joint Infection

Case Reports in Infectious Diseases ◽

10.1155/2020/8431019 ◽

2020 ◽

Vol 2020 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

A. Mc Carthy ◽

J. M. Broderick ◽

A. P. Molloy

Keyword(s):

Septic Arthritis ◽

Neisseria Meningitidis ◽

Joint Infection ◽

Prosthetic Joint ◽

Patient Morbidity ◽

Infection Source ◽

One Year ◽

Arthroplasty Surgery

One of the most feared complications after arthroplasty is infection due to its significant impact on patient morbidity. Infection may transfer to the joint at the time of surgery or be seeded, haematologically, to the prosthetic joint from another infection source. In this case, a 72-year-old female presented with symptoms of septic arthritis seven years after her original arthroplasty surgery. At presentation, she denied trauma and any comorbidity which would predispose her to infection. Culturing of samples taken revealed the patient was infected with Neisseria meningitidis, and the patient underwent a DAIR procedure. She continued postoperative long-term antimicrobial therapy with resolution of her infection. Follow-up at one year showed complete resolution of the patient’s illness with a return to premorbid baseline. To our knowledge, this is the third reported case of septic arthritis caused by Neisseria meningitidis in a prosthetic joint in the literature.

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Epidemiology, Management, and Outcomes of Large and Small Native Joint Septic Arthritis in Adults

Clinical Infectious Diseases ◽

10.1093/cid/ciz265 ◽

2019 ◽

Vol 70 (2) ◽

pp. 271-279 ◽

Cited By ~ 11

Author(s):

Stephen McBride ◽

Jessica Mowbray ◽

William Caughey ◽

Edbert Wong ◽

Christopher Luey ◽

...

Keyword(s):

Treatment Failure ◽

Septic Arthritis ◽

Surgical Procedures ◽

Joint Infections ◽

Prosthetic Joint ◽

Total Incidence ◽

Large Joint ◽

Prosthetic Joint Infections ◽

Small Joint ◽

Antibiotic Duration

Abstract Background Native joint septic arthritis (NJSA) is poorly studied. We describe the epidemiology, treatment, and outcomes of large joint NJSA (LNJSA) and small joint NJSA (SNJSA) in adults at Middlemore Hospital, Auckland, New Zealand. Methods This was a coding-based retrospective study of patients ≥16 years old admitted between 2009 and 2014. Prosthetic joint infections were excluded. Results Five hundred forty-three NJSA episodes were included (302 LNJSA, 250 SNJSA). Only 40% had positive synovial fluid culture. Compared to SNJSA, LNJSA has higher incidence (13 vs 8/100 000 person-years [PY]), occurs in older, more comorbid patients, and is associated with greater rates of treatment failure (23% vs 12%) and mortality, despite longer antibiotic treatment. Total incidence is higher than previously reported (21/100 000 PY), with marked interethnic variation. Incidence rises with age (LNJSA only) and socioeconomic deprivation (LNJSA and SNJSA). Tobacco smokers and males are overrepresented. The most commonly involved joints were knee (21%) and hand interphalangeal (20%). Staphylococcus aureus was the most common pathogen (53%). Mean antibiotic duration was 25 days for SNJSA and 40 days for LNJSA, and the mean number of surgical procedures was 1.5 and 1.6, respectively. Treatment failure was independently associated with LNJSA, age, intra-articular nonarthroplasty prosthesis, and number of surgical procedures. Conclusions This is the largest contemporary series of adult NJSA. SNJSA has better outcomes than LNJSA and may be able to be safely treated with shorter antimicrobial courses. Incidence is high, with significant ethnic and socioeconomic variation. Microbiological NJSA case ascertainment underestimates case numbers as it frequently excludes SNJSA.

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A Real Pain: Diagnostic Quandaries and Septic Arthritis

Journal of Clinical Microbiology ◽

10.1128/jcm.01358-17 ◽

2017 ◽

Vol 56 (2) ◽

Cited By ~ 1

Author(s):

Cristina Costales ◽

Susan M. Butler-Wu

Keyword(s):

Septic Arthritis ◽

Laboratory Tests ◽

Joint Infection ◽

Rapid Diagnosis ◽

Accurate Diagnosis ◽

Joint Infections ◽

Prosthetic Joint ◽

Prosthetic Joint Infections ◽

The Many ◽

Future Utility

ABSTRACT Rapid diagnosis and treatment of an infected joint are paramount in preserving orthopedic function. Here, we present a brief review of the many challenges associated with the diagnosis of both septic arthritis and prosthetic joint infections. We also discuss the many laboratory tests currently available to aid in the accurate diagnosis of joint infection, as well as emerging diagnostics that may have future utility in the diagnosis of these challenging clinical entities.

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