A systematic exploration of temporal bisection models across sub- and supra-second duration ranges

2020 ◽  
Vol 94 ◽  
pp. 102311
Author(s):  
Nicholas A. Lusk ◽  
Elijah A. Petter ◽  
Warren H. Meck
2019 ◽  
Vol 45 (1) ◽  
pp. 75-94 ◽  
Author(s):  
Renata Cambraia ◽  
Marco Vasconcelos ◽  
Jérémie Jozefowiez ◽  
Armando Machado

2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.


2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.


Fuel ◽  
2021 ◽  
Vol 287 ◽  
pp. 119434
Author(s):  
Jun Chen ◽  
Hongliang Li ◽  
Chunfu Liu ◽  
Lingyun Liu ◽  
Yu Sun ◽  
...  

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
Anamaría Font ◽  
Bernardo Fraiman ◽  
Mariana Graña ◽  
Carmen A. Núñez ◽  
Héctor Parra De Freitas

Abstract Compactifications of the heterotic string on special Td/ℤ2 orbifolds realize a landscape of string models with 16 supercharges and a gauge group on the left-moving sector of reduced rank d + 8. The momenta of untwisted and twisted states span a lattice known as the Mikhailov lattice II(d), which is not self-dual for d > 1. By using computer algorithms which exploit the properties of lattice embeddings, we perform a systematic exploration of the moduli space for d ≤ 2, and give a list of maximally enhanced points where the U(1)d+8 enhances to a rank d + 8 non-Abelian gauge group. For d = 1, these groups are simply-laced and simply-connected, and in fact can be obtained from the Dynkin diagram of E10. For d = 2 there are also symplectic and doubly-connected groups. For the latter we find the precise form of their fundamental groups from embeddings of lattices into the dual of II(2). Our results easily generalize to d > 2.


Genetics ◽  
2002 ◽  
Vol 160 (2) ◽  
pp. 675-682
Author(s):  
Victoria L Browning ◽  
Rebecca A Bergstrom ◽  
Sandra Daigle ◽  
John C Schimenti

Abstract Proper levels of gene expression are important for normal mammalian development. Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality or birth defects. Segmental aneuploidy can be compatible with life but often results in contiguous gene syndromes. The ability to manipulate the mouse genome allows the systematic exploration of regions that are affected by alterations in gene dosage. To explore the effects of segmental haploidy in the mouse t complex on chromosome 17, radiation-induced deletion complexes centered at the Sod2 and D17Leh94 loci were generated in embryonic stem (ES) cells. A small interval was identified that, when hemizygous, caused specific embryonic lethal phenotypes (exencephaly and edema) in most fetuses. The penetrance of these phenotypes was background dependent. Additionally, evidence for parent-of-origin effects was observed. This genetic approach should be useful for identifying genes that are imprinted or whose dosage is critical for normal embryonic development.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Gerard Karsenty

Abstract We hypothesized that bone may secrete hormones that regulate energy metabolism and reproduction. Testing this hypothesis revealed that the osteoblast-specific secreted protein osteocalcin is a hormone regulating glucose homeostasis and male fertility by signaling through a GPCR, Gprc6a, expressed in pancreatic β bells and Leydig cells of the testes. The systematic exploration of osteocalcin biology, revealed that it regulates an unexpectedly large spectrum of physiological functions in the brain and peripheral organs and that it has most features of an antigeromic molecule. As will be presented at the meeting, this body of work suggests that harnessing osteocalcin for therapeutic purposes may be beneficial in the treatment of age-related diseases such as depression, age-related memory loss and the decline in muscle function seen in sarcopenia.


1955 ◽  
Vol 45 (1-2) ◽  
pp. 106-115 ◽  
Author(s):  
Giacomo Caputo ◽  
Richard Goodchild

Introduction.—The systematic exploration of Ptolemais (modern Tolmeita), in Cyrenaica, began in 1935 under the auspices of the Italian Government, and under the direction of the first-named writer. The general programme of excavation took into consideration not only the important Hellenistic period, which gave the city its name and saw its first development as an autonomous trading-centre, but also the late-Roman age when, upon Diocletian's reforms, Ptolemais became capital of the new province of Libya Pentapolis and a Metropolitan See, later occupied by Bishop Synesius.As one of several starting-points for the study of this later period, there was selected the area first noted by the Beecheys as containing ‘heaps of columns’, which later yielded the monumental inscriptions of Valentinian, Arcadius, and Honorius, published by Oliverio. Here excavation soon brought to light a decumanus, running from the major cardo on the west towards the great Byzantine fortress on the east. Architectural and other discoveries made in 1935–36 justified the provisional title ‘Monumental Street’ assigned to this ancient thoroughfare. In terms of the general town-plan, which is extremely regular, this street may be called ‘Decumanus II North’, since two rows of long rectangular insulae separate it from the Decumanus Maximus leading to the West Gate, still erect. The clearing of the Monumental Street and its frontages revealed the well-known Maenad reliefs, attributed to the sculptor Callimachus, a late-Roman triple Triumphal Arch, and fragments of monumental inscriptions similar in character to those previously published from the same area.


Cryptography ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Niluka Amarasinghe ◽  
Xavier Boyen ◽  
Matthew McKague

The modern financial world has seen a significant rise in the use of cryptocurrencies in recent years, partly due to the convincing lure of anonymity promised by these schemes. Bitcoin, despite being considered as the most widespread among all, is claimed to have significant lapses in relation to its anonymity. Unfortunately, studies have shown that many cryptocurrency transactions can be traced back to their corresponding participants through the analysis of publicly available data, to which the cryptographic community has responded by proposing new constructions with improved anonymity claims. Nevertheless, the absence of a common metric for evaluating the level of anonymity achieved by these schemes has led to numerous disparate ad hoc anonymity definitions, making comparisons difficult. The multitude of these notions also hints at the surprising complexity of the overall anonymity landscape. In this study, we introduce such a common framework to evaluate the nature and extent of anonymity in (crypto) currencies and distributed transaction systems, thereby enabling one to make meaningful comparisons irrespective of their implementation. Accordingly, our work lays the foundation for formalizing security models and terminology across a wide range of anonymity notions referenced in the literature, while showing how “anonymity” itself is a surprisingly nuanced concept, as opposed to existing claims that are drawn upon at a higher level, thus missing out on the elemental factors underpinning anonymity.


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