Analysis of the time-varying energy of brain responses to an oddball paradigm using short-term smoothed Wigner–Ville distribution

2005 ◽  
Vol 143 (2) ◽  
pp. 197-208 ◽  
Author(s):  
M.E. Tağluk ◽  
E.D. Çakmak ◽  
S. Karakaş
BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sahamoddin Khailaie ◽  
Tanmay Mitra ◽  
Arnab Bandyopadhyay ◽  
Marta Schips ◽  
Pietro Mascheroni ◽  
...  

Abstract Background SARS-CoV-2 has induced a worldwide pandemic and subsequent non-pharmaceutical interventions (NPIs) to control the spread of the virus. As in many countries, the SARS-CoV-2 pandemic in Germany has led to a consecutive roll-out of different NPIs. As these NPIs have (largely unknown) adverse effects, targeting them precisely and monitoring their effectiveness are essential. We developed a compartmental infection dynamics model with specific features of SARS-CoV-2 that allows daily estimation of a time-varying reproduction number and published this information openly since the beginning of April 2020. Here, we present the transmission dynamics in Germany over time to understand the effect of NPIs and allow adaptive forecasts of the epidemic progression. Methods We used a data-driven estimation of the evolution of the reproduction number for viral spreading in Germany as well as in all its federal states using our model. Using parameter estimates from literature and, alternatively, with parameters derived from a fit to the initial phase of COVID-19 spread in different regions of Italy, the model was optimized to fit data from the Robert Koch Institute. Results The time-varying reproduction number (Rt) in Germany decreased to <1 in early April 2020, 2–3 weeks after the implementation of NPIs. Partial release of NPIs both nationally and on federal state level correlated with moderate increases in Rt until August 2020. Implications of state-specific Rt on other states and on national level are characterized. Retrospective evaluation of the model shows excellent agreement with the data and usage of inpatient facilities well within the healthcare limit. While short-term predictions may work for a few weeks, long-term projections are complicated by unpredictable structural changes. Conclusions The estimated fraction of immunized population by August 2020 warns of a renewed outbreak upon release of measures. A low detection rate prolongs the delay reaching a low case incidence number upon release, showing the importance of an effective testing-quarantine strategy. We show that real-time monitoring of transmission dynamics is important to evaluate the extent of the outbreak, short-term projections for the burden on the healthcare system, and their response to policy changes.


Author(s):  
Daniele Bianchi ◽  
Matthias Büchner ◽  
Andrea Tamoni

Abstract We show that machine learning methods, in particular, extreme trees and neural networks (NNs), provide strong statistical evidence in favor of bond return predictability. NN forecasts based on macroeconomic and yield information translate into economic gains that are larger than those obtained using yields alone. Interestingly, the nature of unspanned factors changes along the yield curve: stock- and labor-market-related variables are more relevant for short-term maturities, whereas output and income variables matter more for longer maturities. Finally, NN forecasts correlate with proxies for time-varying risk aversion and uncertainty, lending support to models featuring both channels.


2020 ◽  
Vol 10 (6) ◽  
pp. 2038 ◽  
Author(s):  
Yanpeng Wang ◽  
Leina Zhao ◽  
Shuqing Li ◽  
Xinyu Wen ◽  
Yang Xiong

Short-term traffic flow prediction is important to realize real-time traffic instruction. However, due to the existing strong nonlinearity and non-stationarity in short-term traffic volume data, it is hard to obtain a satisfactory result through the traditional method. To this end, this paper develops an innovative hybrid method based on the time varying filtering based empirical mode decomposition (TVF-EMD) and least square support vector machine (LSSVM). Specifically, TVF-EMD is firstly used to deal with the implied non-stationarity in the original data by decomposing them into several different subseries. Then, the LSSVM models are established for each subseries to capture the linear and nonlinear characteristics embedded in the original data, and the corresponding prediction results are superimposed to obtain the final one. Finally, case studies based on two groups of data measured from an arterial road intersection are employed to evaluate the performance of the proposed method. The experimental results indicate it outperforms the other involved models. For example, compared with the LSSVM model, the average improvements by the proposed method in terms of the indexes of mean absolute error, mean relative percentage error, root mean square error and root mean square relative error are 7.397, 15.832%, 10.707 and 24.471%, respectively.


2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A12.1-A12
Author(s):  
Sally Picciotto ◽  
Andreas Neophytou ◽  
Mark Cullen ◽  
Ellen Eisen

IntroductionShort-term disability leave can be considered as a measure of not being well enough to work. The American Manufacturing Cohort, followed 1996–2013, consists of employees of a light-metal company that provided short-term disability insurance to all employees: coverage to replace wages for up to 6 months of work absence due to medical issues. We hypothesized that since brief short-term disability leave allows workers time to recover from illness or injury without losing their jobs, it should be protective against employment termination.MethodsWe analyzed 18 386 (83% male, 80% white) hourly employees. We censored workers once their accumulated disability leave exceeded 6 weeks because longer time spent on short-term disability leave suggests more serious illness or injury that may prevent return to work. To analyze the effect of short-term disability leave on employment termination, we applied a marginal structural pooled logistic model that allowed for a time-varying hazard function. We adjusted for time-varying confounding by occupational exposures and health-related variables using inverse probability weighting. Using the estimated coefficients, we compared the predicted probabilities (by person-month) of terminating employment with the corresponding counterfactual probabilities if the worker had never taken disability leave. These probabilities yielded estimated survival curves under the two scenarios.ResultsThe average worker was followed for 5.5 years. Approximately 42% of the workers took at least one day of disability leave, and 48% terminated employment during follow-up. We estimated that 1058 (29%) more workers would have terminated employment within 5 years from cohort entry if the company had had no disability leave benefit than were predicted under the natural course.ConclusionShort-term disability leave is a potentially relevant health variable for occupational epidemiologists. This analysis suggests that short-term disability leave can help employees retain their jobs when a temporary health issue prevents them from working.


2019 ◽  
Author(s):  
Ana A. Francisco ◽  
John J. Foxe ◽  
Douwe J. Horsthuis ◽  
Danielle DeMaio ◽  
Sophie Molholm

AbstractBackground22q11.2 Deletion Syndrome (22q11.2DS) is the strongest known molecular risk factor for schizophrenia. Brain responses to auditory stimuli have been studied extensively in schizophrenia and described as potential biomarkers of vulnerability to psychosis. We sought to understand whether these responses might aid in differentiating individuals with 22q11.2DS as a function of psychotic symptoms, and ultimately serve as signals of risk for schizophrenia.MethodsA duration oddball paradigm and high-density electrophysiology were used to test auditory processing in 26 individuals with 22q11.2DS (13-35 years old, 17 females) with varying degrees of psychotic symptomatology and in 26 age- and sex-matched neurotypical controls (NT). Presentation rate varied across three levels, to examine the effect of increasing demands on memory and the integrity of sensory adaptation. We tested whether N1 and mismatch negativity (MMN), typically reduced in schizophrenia, related to clinical/cognitive measures, and how they were affected by presentation rate.ResultsN1 adaptation effects interacted with psychotic symptomatology: Compared to an NT group, individuals with 22q11.2DS but no psychotic symptomatology presented larger adaptation effects, whereas those with psychotic symptomatology presented smaller effects. In contrast, individuals with 22q11.2DS showed increased effects of presentation rate on MMN amplitude, regardless of the presence of symptoms. While IQ and working memory were lower in the 22q11.2DS group, these measures did not correlate with the electrophysiological data.ConclusionsThese findings suggest the presence of two distinct mechanisms: One intrinsic to 22q11.2DS resulting in increased N1 and MMN responses; another related to psychosis leading to a decreased N1 response.


2019 ◽  
Author(s):  
Keiichi Kitajo ◽  
Takumi Sase ◽  
Yoko Mizuno ◽  
Hiromichi Suetani

AbstractIt is an open question as to whether macroscopic human brain responses to repeatedly presented external inputs show consistent patterns across trials. We here provide experimental evidence that human brain responses to noisy time-varying visual inputs, as measured by scalp electroencephalography (EEG), show a signature of consistency. The results indicate that the EEG-recorded responses are robust against fluctuating ongoing activity, and that they respond to visual stimuli in a repeatable manner. This consistency presumably mediates robust information processing in the brain. Moreover, the EEG response waveforms were discriminable between individuals, and were invariant over a number of days within individuals. We reveal that time-varying noisy visual inputs can harness macroscopic brain dynamics and can manifest hidden individual variations.


2020 ◽  
Vol 9 (3) ◽  
pp. 146-156
Author(s):  
Peterson Owusu Junior ◽  
Imhotep Alagidede ◽  
George Tweneboah

We explore interdependence and contagion in the top 9 emerging markets and the US equities using a novel time-varying GLD-based Baruník & Křehlík (2018) (BK18) spillover technique. The GLD accounts for the extreme returns while the BK18 capture the nonlinear, nonstationary, asymmetric, and time-dependent comovements in higher moments. We find dominance of some emerging markets instead of the US in the frequency-dependent spillovers. We also establish shape shift-contagion in emerging markets equities in the short-term. Our results shed new light on the sources of connectedness and contagion through the shape parameters of equity returns.


2020 ◽  
Author(s):  
Julia Moser ◽  
Franziska Schleger ◽  
Magdalene Weiss ◽  
Katrin Sippel ◽  
Lorenzo Semeia ◽  
...  

AbstractThe concept of fetal consciousness is a widely discussed topic. In this study, we applied a hierarchical rule learning paradigm to investigate the possibility of fetal conscious processing during the last trimester of pregnancy. We used fetal magnetoencephalography, to assess fetal brain activity in 56 healthy fetuses between gestational week 25 and 40, during an auditory oddball paradigm containing first- and second-order regularities. The comparison of fetal brain responses towards standard and deviant tones revealed that fetuses show signs of hierarchical rule learning, and thus the formation of a memory trace for the second-order regularity. This ability develops over the course of the last trimester of gestation, in accordance with processes in physiological brain development. On the whole, our results support the assumption that fetuses are capable of consciously processing stimuli that reach them from outside the womb.


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