Relation between plasmatic and cerebrospinal fluid oxidative stress biomarkers and intrathecal Ig synthesis in Multiple Sclerosis patients

2015 ◽  
Vol 283 ◽  
pp. 39-42 ◽  
Author(s):  
Livia Pasquali ◽  
Chiara Pecori ◽  
Lucia Chico ◽  
Alfonso Iudice ◽  
Gabriele Siciliano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Multiple Sclerosis Patients ◽  
Ig Synthesis

Evaluation of Delta-Aminolevulinic Dehydratase Activity, Oxidative Stress Biomarkers, and Vitamin D Levels in Patients with Multiple Sclerosis

2015 ◽  
Vol 29 (2) ◽  
pp. 230-242 ◽  
Author(s):  
Carla Roberta Nunes Polachini ◽  
Roselia Maria Spanevello ◽  
Daniela Zanini ◽  
Jucimara Baldissarelli ◽  
Luciane Belmonte Pereira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Vitamin D Levels ◽  
Dehydratase Activity

Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients

2008 ◽  
Vol 14 (8) ◽  
pp. 1056-1060 ◽  
Author(s):  
M Hirotani ◽  
C Maita ◽  
M Niino ◽  
SM Iguchi-Ariga ◽  
S Hamada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Healthy Subjects ◽  
Significant Positive Correlation ◽  
Healthy Controls ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Multiple Sclerosis Patients

Objectives DJ-1 plays a key role in the anti-oxidative stress function. Increasing evidence supports the role of oxidative stress in the pathogenesis of multiple sclerosis (MS). The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS. Methods Quantitative immunoblot assays were performed to evaluate the DJ-1 level in serum and cerebrospinal fluid (CSF) collected from relapsing–remitting patients with MS ( n = 29), disease controls subjects ( n = 14), and healthy subjects ( n = 44). Results No significant difference was observed in the serum DJ-1 level among the patients with MS, disease controls, and healthy controls. However, the CSF DJ-1 levels were significantly higher in the patients with MS than in the disease control subjects ( P < 0.0001). A significant positive correlation was also found between the CSF DJ-1 levels and the Multiple Sclerosis Severity Score ( P < 0.005, r = 0.501). Conclusions These results show that the CSF DJ-1 levels are significantly increased in the CSF of patients with MS and that the CSF DJ-1 levels may be associated with the disease progression of MS. Therefore, DJ-1 possibly plays an important role in the pathogenesis of MS.

Genetic, Immune-Inflammatory, and Oxidative Stress Biomarkers as Predictors for Disability and Disease Progression in Multiple Sclerosis

2016 ◽  
Vol 54 (1) ◽  
pp. 31-44 ◽  
Author(s):  
Ana Paula Kallaur ◽  
Edna Maria Vissoci Reiche ◽  
Sayonara Rangel Oliveira ◽  
Andrea Name Colado Simão ◽  
Wildea Lice de Carvalho Jennings Pereira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Disease Progression ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress

Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients

2007 ◽  
Vol 414 (3) ◽  
pp. 233-236 ◽  
Author(s):  
Niklas Mattsson ◽  
Sara Haghighi ◽  
Oluf Andersen ◽  
Yuemang Yao ◽  
Lars Rosengren ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Healthy Siblings ◽  
Multiple Sclerosis Patients

Plasmatic oxidative stress biomarkers in multiple sclerosis: Relation with clinical and demographic characteristics

2015 ◽  
Vol 48 (1-2) ◽  
pp. 19-23 ◽  
Author(s):  
Livia Pasquali ◽  
Chiara Pecori ◽  
Cinzia Lucchesi ◽  
Annalisa LoGerfo ◽  
Alfonso Iudice ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Demographic Characteristics ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers
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