Changes in the functional connectivity of auditory and language-related brain regions in children with congenital severe sensorineural hearing loss: An fMRI study

2019 ◽  
Vol 51 ◽  
pp. 84-95 ◽  
Author(s):  
Qiang Li ◽  
Huang Guo ◽  
Lihua Liu ◽  
Shuang Xia
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Sensorineural Hearing Loss ◽  
Brain Regions ◽  
Sensorineural Hearing ◽  
Fmri Study

scholarly journals Altered Brain Activity and Functional Connectivity in Unilateral Sudden Sensorineural Hearing Loss

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Jiawei Chen ◽  
Bo Hu ◽  
Peng Qin ◽  
Wei Gao ◽  
Chengcheng Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Visual Cortex ◽  
Functional Connectivity ◽  
Auditory Cortex ◽  
Sensorineural Hearing Loss ◽  
Brain Regions ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Angular Gyrus ◽  
Precentral Gyrus

Background. Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and could lead to social difficulties and mental disorders in some patients. Although many studies have analyzed altered brain function in populations with hearing loss, little information is available about patients with idiopathic SSNHL. This study is aimed at investigating brain functional changes in SSNHL via functional magnetic resonance imaging (fMRI). Methods. Thirty-six patients with SSNHL and thirty well-matched normal hearing individuals underwent resting-state fMRI. Amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and functional connectivity (FC) values were calculated. Results. In the SSNHL patients, ALFF and fALFF were significantly increased in the bilateral putamen but decreased in the right calcarine cortex, right middle temporal gyrus (MTG), and right precentral gyrus. Widespread increases in FC were observed between brain regions, mainly including the bilateral auditory cortex, bilateral visual cortex, left striatum, left angular gyrus (AG), bilateral precuneus, and bilateral limbic lobes in patients with SSNHL. No decreased FC was observed. Conclusion. SSNHL causes functional alterations in brain regions, mainly in the striatum, auditory cortex, visual cortex, MTG, AG, precuneus, and limbic lobes within the acute period of hearing loss.

scholarly journals Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

2020 ◽  
Vol 14 ◽  
Author(s):  
Tian-Yu Tang ◽  
Ying Luan ◽  
Yun Jiao ◽  
Jian Zhang ◽  
Sheng-Hong Ju ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Sensorineural Hearing Loss ◽  
Neural Plasticity ◽  
Sensorineural Hearing ◽  
Track Length ◽  
Healthy Controls ◽  
Emotional States ◽  
Emotional Impairments ◽  
Left And Right

Background and Purpose: Hearing loss is associated with rising risks of emotional impairments, suggesting emotional processing networks might be involved in the neural plasticity after hearing loss. This study was conducted to explore how functional connectivity of the amygdala reconfigures in the auditory deprived brain and better understand the neural mechanisms underlying hearing loss-related emotional disturbances.Methods: In total, 38 chronic sensorineural hearing loss (SNHL) patients and 37 healthy controls were recruited for multimodal magnetic resonance imaging scanning and neuropsychological assessments. Voxel-wise functional connectivity (FC) maps of both the left and right amygdala were conducted and compared between the SNHL patients and healthy controls. The uncinate fasciculus (UF), an association fiber pathway, was reconstructed in both groups. The track number, mean track length, fractional anisotropy (FA) and mean diffusion values of the left and right UF were further quantified, respectively. Besides, Pearson's correlation analyses were conducted to investigate the relationship between the functional/structural abnormalities and the negative emotional states in SNHL patients.Results: The SNHL patients presented higher depressive and anxious levels compared to the healthy controls. Decreased FCs were detected between the amygdala and the auditory cortex, striatum, multimodal processing areas, and frontoparietal control areas in the SNHL patients. The amygdala was found to be structurally connected with several FC decreased regions through the UF. Moreover, the hypo-synchronization and the white matter impairment were both found to be associated with patients' elevated anxious status.Conclusions: These functional and structural findings depicted the reconfiguration of the amygdala in SNHL, which provided a new perspective toward the functional circuit mechanisms targeting the emotional impairments related to hearing loss.

scholarly journals Altered Functional Connectivity in Patients With Sloping Sensorineural Hearing Loss

2019 ◽  
Vol 13 ◽  
Author(s):  
Tomasz Wolak ◽  
Katarzyna Cieśla ◽  
Agnieszka Pluta ◽  
Elżbieta Włodarczyk ◽  
Bharat Biswal ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing

Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI

2015 ◽  
Vol 24 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Bin Liu ◽  
Yuan Feng ◽  
Ming Yang ◽  
Jing-ya Chen ◽  
Jing Li ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Auditory Cortex ◽  
Sensorineural Hearing Loss ◽  
Resting State ◽  
Region Of Interest ◽  
Primary Auditory Cortex ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Resting State Functional Connectivity

Purpose This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging. Method Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without SNHL. Data were collected and analyzed to map functional connectivity using the left/right primary auditory cortex as the region of interest to identify global differences between patients with SNHL and the control group. Results In comparison to the control group, the SNHL group was found to have significant functional connectivity changes in the auditory system, recognition network, visual cortex, and language network. Conclusion These findings suggest that functional brain alterations in unilateral SNHL patients may indicate reorganizations that occur in response to auditory deficits.

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