scholarly journals Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss

2020 ◽  
Vol 14 ◽  
Author(s):  
Tian-Yu Tang ◽  
Ying Luan ◽  
Yun Jiao ◽  
Jian Zhang ◽  
Sheng-Hong Ju ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Sensorineural Hearing Loss ◽  
Neural Plasticity ◽  
Sensorineural Hearing ◽  
Track Length ◽  
Healthy Controls ◽  
Emotional States ◽  
Emotional Impairments ◽  
Left And Right

Background and Purpose: Hearing loss is associated with rising risks of emotional impairments, suggesting emotional processing networks might be involved in the neural plasticity after hearing loss. This study was conducted to explore how functional connectivity of the amygdala reconfigures in the auditory deprived brain and better understand the neural mechanisms underlying hearing loss-related emotional disturbances.Methods: In total, 38 chronic sensorineural hearing loss (SNHL) patients and 37 healthy controls were recruited for multimodal magnetic resonance imaging scanning and neuropsychological assessments. Voxel-wise functional connectivity (FC) maps of both the left and right amygdala were conducted and compared between the SNHL patients and healthy controls. The uncinate fasciculus (UF), an association fiber pathway, was reconstructed in both groups. The track number, mean track length, fractional anisotropy (FA) and mean diffusion values of the left and right UF were further quantified, respectively. Besides, Pearson's correlation analyses were conducted to investigate the relationship between the functional/structural abnormalities and the negative emotional states in SNHL patients.Results: The SNHL patients presented higher depressive and anxious levels compared to the healthy controls. Decreased FCs were detected between the amygdala and the auditory cortex, striatum, multimodal processing areas, and frontoparietal control areas in the SNHL patients. The amygdala was found to be structurally connected with several FC decreased regions through the UF. Moreover, the hypo-synchronization and the white matter impairment were both found to be associated with patients' elevated anxious status.Conclusions: These functional and structural findings depicted the reconfiguration of the amygdala in SNHL, which provided a new perspective toward the functional circuit mechanisms targeting the emotional impairments related to hearing loss.

scholarly journals Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Pingping Guo ◽  
Siyuan Lang ◽  
Muliang Jiang ◽  
Yifeng Wang ◽  
Zisan Zeng ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Prefrontal Cortex ◽  
Sensorineural Hearing Loss ◽  
Resting State ◽  
Regional Homogeneity ◽  
Sensorineural Hearing ◽  
Parahippocampal Gyrus ◽  
Control Group ◽  
Precentral Gyrus ◽  
Healthy Controls

Background: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.Methods: Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group.Results: Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age (p < 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age (p < 0.05).Conclusion: Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL.

Neural Plasticity in Patients with Tinnitus and Sensorineural Hearing Loss

1997 ◽  
pp. 529-534
Author(s):  
Alan H. Lockwood ◽  
Richard J. Salvi ◽  
Mary Lou Coad ◽  
David S. Wack ◽  
Brian W. Murphy
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Neural Plasticity ◽  
Sensorineural Hearing

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

2020 ◽  
Vol 25 (4) ◽  
pp. 209-214
Author(s):  
Junfang Xue ◽  
Xin Ma ◽  
Yunjuan Lin ◽  
Haijun Shan ◽  
Lisheng Yu
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory System ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Vestibular Migraine ◽  
Control Group ◽  
Healthy Controls ◽  
History Of ◽  
Low Tone

Introduction: The aim of this study was to investigate and compare the auditory findings in migraine, vestibular migraine (VM), and healthy controls. Methods: Twenty-eight migraine patients (56 ears), 18 VM (36 ears), and 25 healthy controls (50 ears) were included. Audiometry, speech discrimination scores, distortion product optoacoustic emission (DPOAE), and auditory brainstem response were tested. Results: The pure tone in the VM group showed higher thresholds at lower frequencies (250, 500, 1,000, 2,000 Hz) than the control group, with statistical differences observed (P250 Hz = 0.001, P500 Hz = 0.003, P1,000 Hz = 0.016, P2,000 Hz = 0.002). Compared with the healthy controls, the patients with VM had significantly lower amplitudes of DPOAE at 1 kHz (p < 0.001) and 2 kHz (p = 0.020), and the patients with migraine had lower amplitudes at 2 kHz (p = 0.042). Compared with the control group, the patients with migraine reported prolonged latency of wave V (p = 0.016) and IPL I–V (p = 0.003). The patients with VM had significant prolongation of IPL I–V (p = 0.024). Conclusion: Not only the peripheral, but also the central auditory system was involved in patients with migraine and VM. In particular, lower frequencies of the auditory system were more likely to be involved in VM. The history of migraine may be a cause of low-tone sudden sensorineural hearing loss.

Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss

2013 ◽  
Vol 127 (10) ◽  
pp. 972-976 ◽  
Author(s):  
M Sagit ◽  
M Kavugudurmaz ◽  
S Guler ◽  
M A Somdas
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Mean Platelet Volume ◽  
Density Lipoprotein ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Volume Level ◽  
Loss Severity

AbstractObjective:We aimed to determine: (1) whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss, compared with healthy controls; and (2) whether mean platelet volume level was related to hearing loss severity.Materials and methods:The study included 31 patients with sudden sensorineural hearing loss and 31 age- and sex-matched, healthy controls. Peripheral venous blood samples were taken from subjects and mean platelet volume and levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride were measured.Results:Mean platelet volume was significantly greater in the sudden sensorineural hearing loss group compared with the control group. However, there was no significant correlation between mean platelet volume level and hearing loss severity.Conclusion:Mean platelet volume, a determinant of platelet activation, is elevated in patients with sudden sensorineural hearing loss. To our knowledge, this is the first report investigating mean platelet volume levels in such patients. Our findings indirectly support the hypothesis of vascular impairment as a pathogenetic factor in sudden sensorineural hearing loss.

scholarly journals Altered Functional Connectivity in Patients With Sloping Sensorineural Hearing Loss

2019 ◽  
Vol 13 ◽  
Author(s):  
Tomasz Wolak ◽  
Katarzyna Cieśla ◽  
Agnieszka Pluta ◽  
Elżbieta Włodarczyk ◽  
Bharat Biswal ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing
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