Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise

2005 ◽  
Vol 16 (9) ◽  
pp. 530-537 ◽  
Author(s):  
Steven R. McAnulty ◽  
Lisa S. McAnulty ◽  
David C. Nieman ◽  
Jason D. Morrow ◽  
Leslie A. Shooter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plasma Homocysteine ◽  
Alpha Tocopherol ◽  
Exhaustive Exercise ◽  
Before And After ◽  
And Oxidative Stress

scholarly journals Effects of Monomeric and Oligomeric Flavanols on Kidney Function, Inflammation and Oxidative Stress in Runners: A Randomized Double-Blind Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1634 ◽  
Author(s):  
Khrystyna O. Semen ◽  
Antje R. Weseler ◽  
Marcel J. W. Janssen ◽  
Marie-José Drittij-Reijnders ◽  
Jos L. M. L. le Noble ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Kidney Function ◽  
Randomized Study ◽  
Kidney Injury ◽  
Strenuous Exercise ◽  
Vitis Vinifera L ◽  
Grape Seeds ◽  
Double Blind ◽  
Before And After ◽  
And Oxidative Stress

Nonsteroidal anti-inflammatory drugs are frequently used by athletes in order to prevent musculoskeletal pain and improve performance. In combination with strenuous exercise, they can contribute to a reduction of renal blood flow and promote development of kidney damage. We aimed to investigate whether monomeric and oligomeric flavanols (MOF) could reduce the severity of kidney injuries associated with the intake of 400-mg ibuprofen followed by the completion of a half-marathon in recreational athletes. In this double-blind, randomized study, the original MOF blend of extracts from grape seeds (Vitis vinifera L.) and pine bark (Pinus pinaster L.) or placebo were taken for 14 days preceding the ibuprofen/half-marathon. Urine samples were collected before and after the ibuprofen/half-marathon, and biomarkers of kidney injury, inflammation and oxidative stress were assessed. Intake of MOF significantly reduced the incidence of post-race hematuria (p = 0.0004) and lowered concentrations of interleukin (IL)-6 in the urine (p = 0.032). Urinary neutrophil-associated lipocalin, creatine, albumin, IL-8 and malondialdehyde tended to decrease. The supplementation with MOF in recreational runners appears to safely preserve kidney function, reduce inflammation and promote antioxidant defense during strenuous exercise and intake of a single dose of ibuprofen.

scholarly journals Homocysteine Exposure Impairs Myocardial Resistance to Ischaemia Reperfusion and Oxidative Stress

2015 ◽  
Vol 37 (6) ◽  
pp. 2265-2274 ◽  
Author(s):  
Amer Almashhadany ◽  
Dareuosh Shackebaei ◽  
Thomas Van der Touw ◽  
Graham L. Jones ◽  
M.-Saadeh Suleiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Calcium Transient ◽  
Rate Pressure Product ◽  
Rat Cardiomyocytes ◽  
Ischaemia Reperfusion ◽  
Rat Hearts ◽  
Before And After ◽  
Cardiomyocyte Contractility ◽  
Perfused Rat Hearts ◽  
And Oxidative Stress

Background/Aims: Hyperhomocysteinaemia is recognised as a strong independent risk factor for developing cardiovascular disease. This study investigated how an acute homocysteine dose affected cardiac performance during ischaemia reperfusion and cardiomyocyte contractility and morphology under normal conditions and during oxidative stress. Methods: Cardiac function was measured in isolated and perfused rat hearts before and after 40 minutes' global normothermic ischaemia. Where used, 0.1 mM L-homocysteine was present prior to, and throughout ischaemia, before wash out after 10 minutes' reperfusion. Calcium transients under normal conditions and changes in contractile synchronicity during oxidative stress (exposure to 0.2 mM H2O2) were measured in freshly isolated rat cardiomyocytes incubated for 60 minutes ± 0.1 mM L-homocysteine. Results: During ischaemia reperfusion 0.1 mM L-homocysteine significantly reduced the rate pressure product during reperfusion (10,038 ± 749 vs. 5955 ± 567 mmHg bpm, p < 0.001), but did not affect time to ischaemic contracture. Incubation of freshly isolated cardiomyocytes with 0.1 mM L-homocysteine significantly decreased the amplitude of the calcium transient and slowed the time to half relaxation. Conclusions: These findings suggest that homocysteine exposure affected myocardial recovery from ischaemia and contractile homeostasis although the exact mechanisms for these changes remain to be determined.

Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD

2016 ◽  
Vol 21 (6) ◽  
pp. 487-493 ◽  
Author(s):  
İbrahim Fatih Karababa ◽  
Sermin Nur Savas ◽  
Sehabettin Selek ◽  
Erdinc Cicek ◽  
Esra Ismet Cicek ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin B12 ◽  
Adult Adhd ◽  
Plasma Homocysteine ◽  
Serum Folate ◽  
Oxidative Stress Parameters ◽  
Oxidative Balance ◽  
Significant Difference ◽  
And Oxidative Stress ◽  
Stress Parameters

Objective: In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD). Method: Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups. Results: Patients’ plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups ( p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels ( p > .05). Conclusion: Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower.

Dose-dependency of Dammarane Saponins on Blood Inflammatory and Oxidative Stress makers After Exhaustive Exercise

2010 ◽  
Vol 42 ◽  
pp. 779
Author(s):  
Hsien-Tang Lin ◽  
Mallikarjuna Korivi ◽  
Chia-Chen Yang ◽  
Ming-Fen Hsu ◽  
Szu-Hsien Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exhaustive Exercise ◽  
Dose Dependency ◽  
And Oxidative Stress

scholarly journals Study the Haematological parameters and Oxidative stress before and after disbudding in Calves

2021 ◽  
pp. 62-69
Author(s):  
Shiv Swaroop ◽  
Pramanik PS ◽  
Singh KD ◽  
Subodh Kumar ◽  
Verma AK
Keyword(s):  
Oxidative Stress ◽  
Animal Husbandry ◽  
Lipid Peroxides ◽  
Haematological Parameters ◽  
Veterinary Science ◽  
Treatment Groups ◽  
Significant Difference ◽  
Haematological Profile ◽  
Before And After ◽  
And Oxidative Stress

The aim of the present investigation was to examine the haematological profile and oxidative stress before and after disbudding in calves. The study was carried out at Livestock Farm Complex, College of Veterinary Science and Animal Husbandry, ANDUAT, Kumarganj, Ayodhya and nearby villages. Twenty four cattle calves were utilized to study haematological parameters that are Haemoglobin (Hb (gm/dl), Neutrophil (%), Basophil (%), PCV (%), Lymphocyte (%), Monocyte (%), TLC (103/ µl), Eosinophil (%), N/L ratio) and oxidative stress before and after disbudding in to four groups viz. control (T0), lignocaine (TL), tremadol (TT) and lignocaine+tremadol (TL-T). After medication calves were disbudded by hot iron method. The blood samples were collected for haematological parameters & for estimation of LPO (lipid peroxides) as per method described by [1] just before (0h) and after disbudding on 6h, 24h and 72h. The results showed that, at 24h, T0 group showed significantly lowest Hb (10.66±0.49%) which was statistically similar to TT and TL-T groups. At 0h, 6h and 72h means of PCV% were significantly different among treatment groups. The lowest lymphocytes (64.00±1.00) was observed in TT group at 6h. The T0 group showed significantly lowest basophil (0.00±0.00) which was statistically similar to TT and TL-T groups but significantly different from TL group at 6h. At the same interval, T0 group showed significantly lowest monocytes (4.66±0.61) which was significantly different with TL, TT and TL-T groups. At 6h, T0 group showed significantly lowest N/ L ratio (0.15±0.01) which was statistically similar to TT and TL-T groups but significantly different from TL group. At 0h, 6h and 24h LPO was significantly different among groups. At 0h, T0 group showed significantly highest (106.59±0.63) which was significantly different from TL, TT and TL-T groups. It may be concluded that no significant difference was observed in eosinophil%, TLC, neutrophil% and monocyte% counts between control and treatment groups. However, Hb%, basophil%, PCV% and lymphocyte% were significantly different between control and treatment groups. N/L ratio was significant only at 6h. Most of the cases TL-T group showed comparatively better performance. At 0h, 6h and 24h LPO was significantly different among groups. At 0h, T0 group showed significantly highest (106.59±0.63) which was significantly different from TL, TT and TL-T groups.

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