Statistical Models to Assess Leg Muscle Mass in Ambulatory Children With Spastic Cerebral Palsy Using Dual-Energy X-Ray Absorptiometry

We aimed to evaluate muscle mass changes after injection of botulinum toxin (BoNT) in children with spastic hemiplegic cerebral palsy (CP). Children aged between 2 and 12 years who were diagnosed with hemiplegic CP with spastic equinus foot were prospectively recruited and administered BoNT in the affected leg. Lean body mass (LBM) of both legs and total limbs was measured by dual-energy X-ray absorptiometry (DXA) preinjection and 4 and 12 weeks after injection. A total of 15 children were enrolled into the study. LBM of both legs and total limbs increased significantly over 12 weeks of growth. The ratio of LBM of the affected leg to total limbs and to the unaffected leg significantly reduced at 4 weeks after injection compared with preinjection but significantly increased at 12 weeks after injection compared with 4 weeks after injection. In conclusion, the muscle mass of the affected leg after BoNT injection in children with hemiplegic spastic CP decreased at 4 weeks after BoNT injection but significantly recovered after 12 weeks after injection.

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Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass

Journal of Applied Physiology ◽

10.1152/jappl.1999.87.4.1513 ◽

1999 ◽

Vol 87 (4) ◽

pp. 1513-1520 ◽

Cited By ~ 273

Author(s):

Marjolein Visser ◽

Thomas Fuerst ◽

Thomas Lang ◽

Loran Salamone ◽

Tamara B. Harris ◽

...

Keyword(s):

Muscle Mass ◽

Dual Energy ◽

Fat Free Mass ◽

Elderly Persons ◽

X Ray ◽

Total Body Fat ◽

The Mean ◽

Leg Muscle ◽

The Difference ◽

Total Body

The aim of the study was to examine the accuracy of fan-beam dual-energy X-ray absorptiometry (DEXA) for measuring total body fat-free mass (FFM) and leg muscle mass (MM) in elderly persons. Participants were 60 men and women aged 70–79 yr and with a body mass index of 17.5–39.8 kg/m2. FFM and MM at four leg regions were measured by using DEXA (Hologic 4500A, v8.21). A four-compartment body composition model (4C) and multislice computed tomography (CT) of the legs were used as the criterion methods for FFM and MM, respectively. FFM by DEXA was positively associated with FFM by 4C ( R 2 = 0.98, SE of estimate = 1.6 kg). FFM by DEXA was higher [53.5 ± 12.0 (SD) kg] than FFM by 4C (51.6 ± 11.9 kg; P < 0.001). No association was observed between the difference and the mean of the two methods. MM by DEXA was positively associated with CT at all four leg regions ( R 2 = 0.86–0.96). MM by DEXA was higher than by CT in three regions. The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons.

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AB0267 BODY COMPOSITION IN PATIENTS WITH RHEUMATOID ARTHRITIS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2318 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1432.2-1432

Author(s):

N. Toroptsova ◽

O. Dobrovolskaya ◽

N. Demin ◽

L. Shornikova

Keyword(s):

Rheumatoid Arthritis ◽

Body Composition ◽

Muscle Mass ◽

Dual Energy ◽

X Ray ◽

T Score ◽

Osteosarcopenic Obesity ◽

The Mean ◽

Total Fat ◽

Appendicular Muscle Mass

Background:Rheumatoid arthritis (RA) is a complex inflammatory disease that modifies body composition. Using the dual-energy x-ray absorptiometry (DXA) in RA patients could be a method for body composition changes detection.Objectives:To study the body composition using DXA in patients with RA.Methods:The study involved 79 women with RA, median age 60 [55; 65] years. The bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry using «Discovery A» (Hologic, USA). Assessment of body composition was carried out, using the program «Whole body». Sarcopenia (SP) was diagnosed as a decrease in appendicular mass index (AMI) <6.0 kg/m2. Osteoporosis (OP) was diagnosed as a decrease in T-score <-2.5 SD. Osteosarcopenia was determined when T-score was <-1.0 SD, AMI was <6.0 kg/m2, osteosarcopenic obesity - T-score was <-1.0 SD, AMI was <6.0 kg/m2and total fat was >35%.Results:The mean duration of RA was 9 [3; 11] years. The mean body mass index (BMI) was 27.6±4.8 kg/m2. Disease activity score in 28 joints-erythrocyte sedimentation rate was 4.5±1.3 points for the group. 39 (49.3%) patients used oral glucocorticoids continuously. Appendicular muscle mass and AMI were on average 17.8±3.0 kg and 6.8±1.0 kg/m2, respectively. AMI <6 kg/m2was detected in 20 (25.3%) patients. 56 (70.9%) women with RA had total fat > 35%, while only 22 (27.8%) of women with RA had obesity according to BMI (BMI >30 kg/m2). Isolated OP was found in 13 (16.5%), osteosarcopenia in 7 (8.9%) and osteosarcopenic obesity in 13 (16.5%) patients RA. No cases with isolated sarcopenia or sarcopenic obesity were detected. Only 3 (3.8%) patients did not have appendicular muscle mass, AMI and BMD decrease and overfat or obesity.Conclusion:About 97% women with RA had abnormal body composition phenotype: 16,5% - OP, 8.9% -osteosarcopenia, 16,5% - osteosarcopenic obesity and 54,4% - overfat.Disclosure of Interests:None declared

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Concordance between muscle mass assessed by bioelectrical impedance analysis and by dual energy X-ray absorptiometry: a cross-sectional study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-015-0510-9 ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 68

Author(s):

Fanny Buckinx ◽

Jean-Yves Reginster ◽

Nadia Dardenne ◽

Jean-Louis Croisiser ◽

Jean-François Kaux ◽

...

Keyword(s):

Muscle Mass ◽

Bioelectrical Impedance Analysis ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Cross Sectional Study ◽

Dual Energy ◽

Sectional Study ◽

Cross Sectional ◽

X Ray

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Determination of Body Composition in Children with Cerebral Palsy: Bioelectrical Impedance Analysis and Anthropometry vs Dual-Energy X-Ray Absorptiometry

Journal of the American Dietetic Association ◽

10.1016/j.jada.2005.02.006 ◽

2005 ◽

Vol 105 (5) ◽

pp. 794-797 ◽

Cited By ~ 26

Author(s):

Li-Fen Liu ◽

Ryan Roberts ◽

Laurie Moyer-Mileur ◽

Lisa Samson-Fang

Keyword(s):

Body Composition ◽

Cerebral Palsy ◽

Bioelectrical Impedance Analysis ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Dual Energy ◽

X Ray ◽

Children With Cerebral Palsy

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Creatine (methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA

Journal of Applied Physiology ◽

10.1152/japplphysiol.00455.2016 ◽

2018 ◽

Vol 124 (1) ◽

pp. 1-9 ◽

Cited By ~ 17

Author(s):

Richard V. Clark ◽

Ann C. Walker ◽

Ram R. Miller ◽

Robin L. O’Connor-Semmes ◽

Eric Ravussin ◽

...

Keyword(s):

Muscle Mass ◽

Dual Energy ◽

Intraindividual Variability ◽

Whole Body ◽

Dilution Method ◽

X Ray ◽

Spot Urine ◽

Spot Urine Sample ◽

Liquid Chromatography Tandem Mass ◽

Total Body

A noninvasive method to estimate muscle mass based on creatine ( methyl-d3) (D3-creatine) dilution using fasting morning urine was evaluated for accuracy and variability over a 3- to 4-mo period. Healthy older (67- to 80-yr-old) subjects ( n = 14) with muscle wasting secondary to aging and four patients with chronic disease (58–76 yr old) fasted overnight and then received an oral 30-mg dose of D3-creatine at 8 AM ( day 1). Urine was collected during 4 h of continued fasting and then at consecutive 4- to 8-h intervals through day 5. Assessment was repeated 3–4 mo later in 13 healthy subjects and 1 patient with congestive heart failure. Deuterated and unlabeled creatine and creatinine were measured using liquid chromatography–tandem mass spectrometry. Total body creatine pool size and muscle mass were calculated from D3-creatinine enrichment in urine. Muscle mass was also measured by whole body MRI and 24-h urine creatinine, and lean body mass (LBM) was measured by dual-energy X-ray absorptiometry (DXA). D3-creatinine urinary enrichment from day 5 provided muscle mass estimates that correlated with MRI for all subjects ( r = 0.88, P < 0.0001), with less bias [difference from MRI = −3.00 ± 2.75 (SD) kg] than total LBM assessment by DXA, which overestimated muscle mass vs. MRI (+22.5 ± 3.7 kg). However, intraindividual variability was high with the D3-creatine dilution method, with intrasubject SD for estimated muscle mass of 2.5 kg vs. MRI (0.5 kg) and DXA (0.8 kg). This study supports further clinical validation of the D3-creatine method for estimating muscle mass. NEW & NOTEWORTHY Measurement of creatine ( methyl-d3) (D3-creatine) and D3-creatinine excretion in fasted morning urine samples may be a simple, less costly alternative to MRI or dual-energy X-ray absorptiometry (DXA) to calculate total body muscle mass. The D3-creatine enrichment method provides estimates of muscle mass that correlate well with MRI, and with less bias than DXA. However, intraindividual variability is high with the D3-creatine method. Studies to refine the spot urine sample method for estimation of muscle mass may be warranted.

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