Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells

2009 ◽  
Vol 16 (12) ◽  
pp. 1619-1623 ◽  
Author(s):  
Fu Xue Chen ◽  
Wen Wen Ren ◽  
Yang Yang ◽  
Di Shen ◽  
Yijia Zong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Conditioned Medium ◽  
Glioma Cells ◽  
Reciprocal Effects

Effects of sertoli cell-conditioned medium on ventral midbrain neural stem cells: A preliminary report

2008 ◽  
Vol 13 (3-4) ◽  
pp. 241-246 ◽  
Author(s):  
Rania Shamekh ◽  
Samuel Saporta ◽  
Don F. Cameron ◽  
Alison E. Willing ◽  
Cindy D. Sanberg ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Conditioned Medium ◽  
Sertoli Cell ◽  
Preliminary Report ◽  
Ventral Midbrain ◽  
Cell Conditioned Medium

scholarly journals The inhibiting effect of neural stem cells on proliferation and invasion of glioma cells

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76949-76960 ◽  
Author(s):  
Jing An ◽  
Hanqi Yan ◽  
Xingxing Li ◽  
Ruolan Tan ◽  
Xinlin Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Glioma Cells ◽  
Inhibiting Effect ◽  
Proliferation And Invasion

scholarly journals Transmigration of Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60655 ◽  
Author(s):  
Mónica Díaz-Coránguez ◽  
José Segovia ◽  
Adolfo López-Ornelas ◽  
Henry Puerta-Guardo ◽  
Juan Ludert ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Blood Brain Barrier ◽  
Glioma Cells ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Sophia M Blake ◽  
Stefan H Stricker ◽  
Hanna Halavach ◽  
Anna R Poetsch ◽  
George Cresswell ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neural Development ◽  
Combined Treatment ◽  
Glioma Cells ◽  
Wild Type ◽  
Genetic Inactivation ◽  
Primary Glioma ◽  
Human Gbm ◽  
Atm Signaling

Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation. Mechanistically, expression of several GBM-associated genes, including Pdgfra, was normalized by Atmin deletion in the Trp53-null background. Pharmacological ATM inhibition also reduced Pdgfra expression, and reduced the proliferation of Trp53-deficient primary glioma cells from murine and human tumors, while normal neural stem cells were unaffected. Analysis of GBM datasets showed that PDGFRA expression is also significantly increased in human TP53-mutant compared with TP53-wild-type tumors. Moreover, combined treatment with ATM and PDGFRA inhibitors efficiently killed TP53-mutant primary human GBM cells, but not untransformed neural stem cells. These results reveal a new requirement for ATMIN-dependent ATM signaling in TP53-deficient GBM, indicating a pro-tumorigenic role for ATM in the context of these tumors.

Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro

2015 ◽  
Vol 53 (10) ◽  
pp. 7184-7199 ◽  
Author(s):  
Isabele C. Iser ◽  
Stefanie M. Ceschini ◽  
Giovana R. Onzi ◽  
Ana Paula S. Bertoni ◽  
Guido Lenz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Conditioned Medium ◽  
Glioma Cells ◽  
Adipose Derived Stem Cells

Identification of pleiotrophin in conditioned medium secreted from neural stem cells by SELDI-TOF and SELDI-tandem mass spectrometry

2004 ◽  
Vol 152 (2) ◽  
pp. 189-197 ◽  
Author(s):  
Makoto Furuta ◽  
Tetsuya Shiraishi ◽  
Hiroaki Okamoto ◽  
Toshihiro Mineta ◽  
Kazuo Tabuchi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Stem Cells ◽  
Tandem Mass Spectrometry ◽  
Neural Stem Cells ◽  
Conditioned Medium ◽  
Tandem Mass
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