Protective Effects of Follicle-stimulating Hormone Inhibitor on Alveolar Bone Loss Resulting from Experimental Periapical Lesions in Ovariectomized Rats

2010 ◽  
Vol 36 (4) ◽  
pp. 658-663 ◽  
Author(s):  
Shengbo Liu ◽  
Yong Cheng ◽  
Wangmin Xu ◽  
Zhuan Bian
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Follicle Stimulating Hormone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Protective Effects ◽  
Periapical Lesions ◽  
Stimulating Hormone

FSH Aggravates Periodontitis-related Bone Loss in Ovariectomized Rats

2010 ◽  
Vol 89 (4) ◽  
pp. 366-371 ◽  
Author(s):  
S. Liu ◽  
Y. Cheng ◽  
M. Fan ◽  
D. Chen ◽  
Z. Bian
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Clinical Features ◽  
Alveolar Bone ◽  
Follicle Stimulating Hormone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Fsh Receptor ◽  
Histochemical Tests ◽  
Experimental Periodontitis

Alveolar bone loss is one of the prominent pathologic and clinical features of periodontitis. Recently, the direct effect of follicle-stimulating hormone (FSH) on bone resorption has been demonstrated. However, the effect of FSH on alveolar bone loss remains unknown. This study tested the hypothesis that FSH would exacerbate periodontitis-related alveolar bone loss. Experimental periodontitis was induced in ovariectomized rats, and the rats were treated with extrinsic FSH or its inhibitor, leuprorelin. After mandibles were collected, we performed morphological examinations to evaluate bone loss, enzyme histochemical tests for osteoclasts, and immunohistochemical examinations for FSH receptor (FSHR). The results showed that FSH significantly increased alveolar bone resorption compared with non-FSH-treated ovariectomized rats (P < 0.05), and the number of FSHR-positive cells was positively correlated with alveolar bone loss area (r = 0.682, P < 0.01). Our results suggested that FSH can aggravate alveolar bone loss by FSHR, independent of estrogen.

scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

scholarly journals Antiperiodontitis Effects of Magnolia biondii Extract on Ligature-Induced Periodontitis in Rats

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 934 ◽  
Author(s):  
Hae Jin Lee ◽  
Dong-Ryung Lee ◽  
Bong-Keun Choi ◽  
Seung Hwan Yang
Keyword(s):  
Bone Loss ◽  
Tissue Damage ◽  
Alveolar Bone ◽  
Histopathological Examination ◽  
Nuclear Factor Κb ◽  
Alveolar Bone Loss ◽  
Gingival Tissue ◽  
Protective Effects ◽  
Tissue Destruction ◽  
Commercial Kits

Over the past decades, periodontitis has become a rising health problem and caused various diseases. In the many studies shows that some extracts and compound to the prevention and treatment of periodontitis. This study focuses on the effects of inhibition of gingival damage and alveolar bone loss. The aim of this study was to evaluate the protective effects of Magnolia biondii extract (MBE) against ligature-induced periodontitis in rats. A ligature was placed around the molar teeth for 8 weeks, and MBE was administered for 8 weeks. Gingival tissue damage and alveolar bone loss were measured by microcomputed tomography (CT) analysis and histopathological examination. Serum Interluekin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), cyclooxygenases-2 (COX-2), and receptor activator of nuclear factor–κB ligand (RANKL) levels were investigated using commercial kits to confirm the antiperiodontitis effects of MBE. We confirmed that ligature-induced periodontitis resulted in gingival tissue damage and alveolar bone loss. However, treatment for 8 weeks with MBE protected from periodontal tissue damage and downregulated serum inflammatory cytokine factors and RANKL levels. These results suggest that MBE exerts antiperiodontitis effects by inhibiting gingival tissue destruction and alveolar bone loss through regulation of anti-inflammatory cytokines in periodontitis-induced rats.

Protective effects of the angiotensin type 1 receptor antagonist losartan in infection-induced and arthritis-associated alveolar bone loss

2015 ◽  
Vol 50 (6) ◽  
pp. 814-823 ◽  
Author(s):  
C. M. Queiroz-Junior ◽  
K. D. Silveira ◽  
C. R. de Oliveira ◽  
A. P. Moura ◽  
M. F. M. Madeira ◽  
...  
Keyword(s):  
Bone Loss ◽  
Receptor Antagonist ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Protective Effects ◽  
Angiotensin Type

scholarly journals Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling

2017 ◽  
Vol 40 (5) ◽  
pp. 1602-1610
Author(s):  
Zhi-Guo Zhang ◽  
Yan-Jing Chen ◽  
Li-Hua Xiang ◽  
Jing-Hua Pan ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats ◽  
Stat3 Signaling

scholarly journals Estrogen deficiency and periodontal condition in rats: a radiographic and macroscopic study

2006 ◽  
Vol 17 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Ana Lia Anbinder ◽  
Marcela de Almeida Prado ◽  
Marianne Spalding ◽  
Ivan Balducci ◽  
Yasmin Rodarte Carvalho ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Estrogen Deficiency ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Furcation Involvement ◽  
The Impact

The purpose of this study was to evaluate the impact of ovariectomy-induced estrogen deficiency as a risk factor of periodontal disease in rats. Forty 90-day old female rats were either ovariectomized (OVX; n=20) or sham operated (SHAM; n=20). After 30 days, periodontitis was induced by placement of a cotton ligature around the upper second molars of 10 OVX and 10 SHAM animals. All animals were sacrificed 5 weeks later. Body weight was assessed before all surgical procedures. The left hemimaxillas were removed and the percentage of periodontal bone support was determined radiographically and buccal alveolar bone loss was determined macroscopically using an image-analysis software. Furcation involvement was also evaluated. Data were analyzed statistically by ANOVA at 5% significance level. Within the evaluated period, the ovariectomized rats gained more weight than the sham-operated animals (p<0.001). The animals in which periodontitis was induced had less bone support, greater alveolar bone loss and furcation involvement than those without ligature (p<0.001). However, there was no difference between ovariectomized and sham-operated animals (p>0.05). Based on the findings of this study, estrogen deficiency could not be considered as a risk factor for periodontal disease.

scholarly journals Rhizoma Dioscoreae Extract Protects against Alveolar Bone Loss in Ovariectomized Rats via microRNAs Regulation

Nutrients ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 1333-1351 ◽  
Author(s):  
Zhiguo Zhang ◽  
Changheng Song ◽  
Fangzhen Zhang ◽  
Lihua Xiang ◽  
Yanjing Chen ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats
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