scholarly journals Effect of the Association of Nonsteroidal Anti-inflammatory and Antibiotic Drugs on Antibiofilm Activity and pH of Calcium Hydroxide Pastes

2017 ◽  
Vol 43 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Rafaela Pignatti de Freitas ◽  
Vanessa Raquel Greatti ◽  
Murilo Priori Alcalde ◽  
Bruno Cavalini Cavenago ◽  
Rodrigo Ricci Vivan ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Antibiofilm Activity ◽  
Antibiotic Drugs ◽  
Anti Inflammatory

scholarly journals Therapeutic Hydrogel Lenses and the Antibacterial and Antibiotic Drugs Release

2021 ◽  
Vol 11 (4) ◽  
pp. 1931
Author(s):  
Alessandra Pulliero ◽  
Aldo Profumo ◽  
Camillo Rosano ◽  
Alberto Izzotti ◽  
Sergio Claudio Saccà
Keyword(s):  
Antibacterial Activity ◽  
Salmonella Typhimurium ◽  
Drug Availability ◽  
Silicone Hydrogel ◽  
Antibiotic Drugs ◽  
Medical Approach ◽  
Anti Inflammatory ◽  
Gradient Hplc

The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of anti-inflammatory and antibiotic drugs. Three lens types were examined: (1) nonionic hydrogel lenses; (2) ionic hydrogel lenses; and (3) silicone hydrogel lenses. The lenses were incubated with (a) dexamethasone; (b) betamethasone; (c) bromophenacyl bromide; and (d) chloramphenicol. Drug availability was quantified by gradient HPLC, and chloramphenicol antibacterial activity was quantified by testing the inhibition of Salmonella typhimurium growth on agar. The lens allowing the most abundant passage of betamethasone was the ionic hydrogel lens, followed by the silicone hydrogel lens and nonionic hydrogel lens. The lens allowing the most abundant passage of dexamethasone was the ionic hydrogel lens, but only at 0.5 h and 1 h. Regarding chloramphenicol, the ionic hydrogel lens and silicone hydrogel lens allowed more abundant passage than the nonionic hydrogel lens. These results highlight the relevance of adapting lenses to anti-inflammatory therapy, thus allowing a personalized medical approach.

scholarly journals The effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain of asymptomatic uniradicular necrotic teeth: a double blind randomized clinical trial

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1687
Author(s):  
Mohamed Omaia ◽  
Maged Negm ◽  
Yousra Nashaat ◽  
Nehal Nabil ◽  
Amal Othman
Keyword(s):  
Calcium Hydroxide ◽  
Treatment Session ◽  
Double Blind ◽  
Saline Irrigation ◽  
Inflammatory Drug ◽  
Mechanical Preparation ◽  
Triple Antibiotic Paste ◽  
Post Operative Pain ◽  
Significant Difference ◽  
Anti Inflammatory

Background: Flare-ups may occur after root canal treatment which consist of acute exacerbation of asymptomatic pulpal and/or periradicular pathologic condition. The causative factors of interappointment pain include mechanical, chemical or microbial irritation to the pulp or periradicular tissues. The potential role of microorganisms in interappointment pain is why the success of endodontic treatment depends on complete eradication of microorganisms capable of causing an intraradicular or extraradicular infection. This can be achieved by mechanical cleaning and shaping, in conjunction with irrigation and antibacterial agents. The aim of this study was to assess the ability of triple antibiotic paste with the anti-inflammatory drug diclofenac potassium versus calcium hydroxide used as an intra-canal medication in reducing post-operative pain. Methods: 84 patients with asymptomatic uniradicular necrotic teeth were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and triple antibiotic paste with diclofenac potassium group (TAPC). In the first treatment session, intracoronal cavity preparation was performed after rubber dam isolation followed by chemo-mechanical preparation using rotary Protaper Universal files with saline irrigation followed by intra-canal medication placement then postoperative pain was assessed at 24, 48 and 72 hours postoperatively using Visual Analogue Scale (VAS). In the second treatment session, intracanal medications were removed by irrigation using saline followed by obturation. Results: Both intracanal medicaments resulted in a statistically significant decrease in mean pain value from 24 to 48 and 72 hours postoperatively. While when comparing both groups, TAPC intracanal medication showed less post-operative pain compared to that of the CH group at 24, 48 and 72 hours with a statistically significant difference at 48 hours only. Conclusion: Both intracanal medicaments were efficient in reducing post-operative pain in asymptomatic uniradicular necrotic teeth. Trial registration: Clinicaltrial.gov NCT02907489, 20/09/2016.

scholarly journals Dextran Sulfate Polymer Wafer Promotes Corneal Wound Healing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1628
Author(s):  
Remya Ammassam Veettil ◽  
Daniela C. Marcano ◽  
Xiaoyong Yuan ◽  
Mahira Zaheer ◽  
Aparna Adumbumkulath ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dextran Sulfate ◽  
Histopathological Analysis ◽  
Eye Injuries ◽  
Corneal Injury ◽  
Corneal Scarring ◽  
Antibiotic Drugs ◽  
Microbial Infections ◽  
Chemical Spills ◽  
Anti Inflammatory

Eye injuries due to corneal abrasions, chemical spills, penetrating wounds, and microbial infections cause corneal scarring and opacification that result in impaired vision or blindness. However, presently available eye drop formulations of anti-inflammatory and antibiotic drugs are not effective due to their rapid clearance from the ocular surface or due to drug-related side effects such as cataract formation or increased intraocular pressure. In this article, we presented the development of a dextran sulfate-based polymer wafer (DS-wafer) for the effective modulation of inflammation and fibrosis and demonstrated its efficacy in two corneal injury models: corneal abrasion mouse model and alkali induced ocular burn mouse model. The DS-wafers were fabricated by the electrospinning method. We assessed the efficacy of the DS-wafer by light microscopy, qPCR, confocal fluorescence imaging, and histopathological analysis. These studies demonstrated that the DS-wafer treatment is significantly effective in modulating corneal inflammation and fibrosis and inhibited corneal scarring and opacification compared to the unsulfated dextran-wafer treated and untreated corneas. Furthermore, these studies have demonstrated the efficacy of dextran sulfate as an anti-inflammatory and antifibrotic polymer therapeutic.

scholarly journals The effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain of asymptomatic uniradicular necrotic teeth: a double blind randomized clinical trial

F1000Research ◽  
2021 ◽  
Vol 8 ◽  
pp. 1687
Author(s):  
Mohamed Omaia ◽  
Maged Negm ◽  
Yousra Nashaat ◽  
Nehal Nabil ◽  
Amal Othman
Keyword(s):  
Calcium Hydroxide ◽  
Treatment Session ◽  
Double Blind ◽  
Saline Irrigation ◽  
Inflammatory Drug ◽  
Mechanical Preparation ◽  
Triple Antibiotic Paste ◽  
Post Operative Pain ◽  
Significant Difference ◽  
Anti Inflammatory

Background: Flare-ups may occur after root canal treatment which consist of acute exacerbation of asymptomatic pulpal and/or periradicular pathologic condition. The causative factors of interappointment pain include mechanical, chemical or microbial irritation to the pulp or periradicular tissues. The potential role of microorganisms in interappointment pain is why the success of endodontic treatment depends on complete eradication of microorganisms capable of causing an intraradicular or extraradicular infection. This can be achieved by mechanical cleaning and shaping, in conjunction with irrigation and antibacterial agents. The aim of this study was to assess the ability of triple antibiotic paste with the anti-inflammatory drug diclofenac potassium versus calcium hydroxide used as an intra-canal medication in reducing post-operative pain. Methods: 84 patients with asymptomatic uniradicular necrotic teeth were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and triple antibiotic paste with diclofenac potassium group (TAPC). In the first treatment session, intracoronal cavity preparation was performed after rubber dam isolation followed by chemo-mechanical preparation using rotary Protaper Universal files with saline irrigation followed by intra-canal medication placement then postoperative pain was assessed at 24, 48 and 72 hours postoperatively using Visual Analogue Scale (VAS). In the second treatment session, intracanal medications were removed by irrigation using saline followed by obturation. Results: Both intracanal medicaments resulted in a statistically significant decrease in mean pain value from 24 to 48 and 72 hours postoperatively. While when comparing both groups, TAPC intracanal medication showed less post-operative pain compared to that of the CH group at 24, 48 and 72 hours with a statistically significant difference at 48 hours only. Conclusion: Both intracanal medicaments were efficient in reducing post-operative pain in asymptomatic uniradicular necrotic teeth. Trial registration: Clinicaltrial.gov NCT02907489, 20/09/2016.

Effect of association of non-steroidal anti-inflammatory and antibiotic agents with calcium hydroxide pastes on their cytotoxicity and biocompatibility

2019 ◽  
Vol 24 (2) ◽  
pp. 757-763
Author(s):  
Guilherme Ferreira da Silva ◽  
Francine Cesário ◽  
Alan Matheus Ramos Garcia ◽  
Paulo Henrique Weckwerth ◽  
Marco Antônio Húngaro Duarte ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Anti Inflammatory ◽  
Antibiotic Agents
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