DRD3 Ser9Gly Polymorphism Is Related to Thermal Pain Perception and Modulation in Chronic Widespread Pain Patients and Healthy Controls

2009 ◽  
Vol 10 (9) ◽  
pp. 969-975 ◽  
Author(s):  
Stéphane Potvin ◽  
Annie Larouche ◽  
Edith Normand ◽  
Juliana Barcellos de Souza ◽  
Isabelle Gaumond ◽  
...  
Keyword(s):  
Pain Perception ◽  
Chronic Widespread Pain ◽  
Healthy Controls ◽  
Widespread Pain ◽  
Thermal Pain ◽  
Pain Patients

scholarly journals Brain-Derived Neurotrophic Factor and Immune Cells in Osteoarthritis, Chronic Low Back Pain, and Chronic Widespread Pain Patients: Association with Anxiety and Depression

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 327
Author(s):  
Dominique Josephine Dimmek ◽  
Christoph Korallus ◽  
Sabine Buyny ◽  
Gutenbrunner Christoph ◽  
Ralf Lichtinghagen ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Immune Cells ◽  
Chronic Widespread Pain ◽  
Anxiety And Depression ◽  
Low Back ◽  
Widespread Pain ◽  
Chronic Pain Patients ◽  
Pain Patients

Background and Objectives: Musculoskeletal dysfunction can induce several types of chronic pain syndromes. It is of particular interest to elucidate the pathomechanism of different forms of chronic pain. It is possible that patients who have developed chronic widespread pain (CWP) may endure different pathomechanisms as compared to those who suffer from local pain (osteoarthritis, OA) and regional pain (chronic low back pain, cLBP), especially with regard to pain regulation and its related biomediators. The aim of this study was to determine the differences in pathomechanisms among these patients by measuring pain-related biomediators, particularly brain-derived neurotrophic factor (BDNF). Additionally, subpopulations of immune cells were determined in parallel. Materials and Methods: Patients and healthy subjects (HSs) were recruited (age and gender-matched). BDNF was measured from serum samples of patients and HSs and the data of body composition parameters were recorded. Additionally, both patients and HSs were asked to fill in questionnaires related to pain intensity, anxiety, and depression. Results: Our results highlight that the levels of both free and total BDNF are significantly lower in pain patients compared to HSs, with p values of 0.041 and 0.024, respectively. The number of CD3− CD56bright natural killer (NK) cells shows significant differences between the groups. Comparing all chronic pain patients with HSs reveals a significantly lower number of CD4+ CD8+ T cells (p = 0.031), CD3− CD56bright NK cells (p = 0.049) and CD20+ CD3− cells (p = 0.007). Conclusions: To conclude, it seems that a general conformity between the pathomechanisms of different chronic pain diseases exists, although there are unique findings only in specific chronic pain patients.

scholarly journals Thermal Pain Thresholds Are Significantly Associated with Plasma Proteins of the Immune System in Chronic Widespread Pain—An Exploratory Pilot Study Using Multivariate and Network Analyses

2021 ◽  
Vol 10 (16) ◽  
pp. 3652
Author(s):  
Björn Gerdle ◽  
Karin Wåhlén ◽  
Torsten Gordh ◽  
Bijar Ghafouri
Keyword(s):  
Immune System ◽  
Acute Phase Proteins ◽  
Chronic Widespread Pain ◽  
Thermal Stimulus ◽  
Widespread Pain ◽  
Muscle Proteins ◽  
Pain Thresholds ◽  
Complement Factors ◽  
Thermal Pain ◽  
Central Factors

Chronic widespread pain (CWP), including fibromyalgia (FM), is characterized by generalized musculoskeletal pain. An important clinical feature is widespread increased pain sensitivity such as lowered pain thresholds for different stimuli such as heat (HPT) and cold (CPT). There is a growing interest in investigating the activated neurobiological mechanisms in CWP. This explorative proteomic study investigates the multivariate correlation pattern between plasma and muscle proteins and thermal pain thresholds in CWP and in healthy controls (CON). In addition, we analysed whether the important proteins and their networks for CPT and HPT differed between CWP and CON. We used a proteomic approach and analysed plasma and muscle proteins from women with CWP (n = 15) and CON (n = 23). The associations between the proteins and CPT/HPT were analysed using orthogonal partial least square (OPLS). The protein–protein association networks for the important proteins for the two thermal pain thresholds were analysed using STRING database. CWP had lowered pain thresholds for thermal stimulus. These levels were generally not related to the included clinical variables except in CWP for HPT. Highly interacting proteins mainly from plasma showed strong significant associations with CPT and HPT both in CWP and in CON. Marked differences in the important proteins for the two thermal pain thresholds were noted between CWP and CON; more complex patterns emerged in CWP. The important proteins were part of the immune system (acute phase proteins, complement factors, and immunoglobulin factors) or known to interact with the immune system. As expected, CWP had lowered pain thresholds for thermal stimulus. Although different proteins were important in the two groups, there were similarities. For example, proteins related to the host defence/immunity such as acute phase proteins, complement factors, immunoglobulin factors, and cytokines/chemokines (although not in CON for CPT) were important habitual/tonic factors for thermal pain thresholds. The fact that peripheral proteins contribute to thermal pain thresholds does not exclude that central factors also contribute and that complex interactions between peripheral and central factors determine the registered pain thresholds in CWP.

scholarly journals Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity

2019 ◽  
Vol Volume 12 ◽  
pp. 1743-1755 ◽  
Author(s):  
Helene van Ettinger-Veenstra ◽  
Peter Lundberg ◽  
Péter Alföldi ◽  
Martin Södermark ◽  
Thomas Graven-Nielsen ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Chronic Widespread Pain ◽  
Widespread Pain ◽  
Cortical Connectivity ◽  
Default Mode ◽  
Pain Patients

scholarly journals Systemic alterations in plasma proteins from women with chronic widespread pain compared to healthy controls: a proteomic study

2017 ◽  
Vol Volume 10 ◽  
pp. 797-809 ◽  
Author(s):  
Karin Wåhlén ◽  
Patrik Olausson ◽  
Anders K Carlsson ◽  
Nazdar Ghafouri ◽  
Björn Gerdle ◽  
...  
Keyword(s):  
Plasma Proteins ◽  
Chronic Widespread Pain ◽  
Healthy Controls ◽  
Widespread Pain ◽  
Proteomic Study

scholarly journals “My private theory is that it’s all in the head”: Understandings of chronic widespread pain among social workers from municipality job centers in Denmark

2021 ◽  
Vol 8 (1) ◽  
pp. 205510292199536
Author(s):  
Rikke Schultz ◽  
Peter la Cour ◽  
Marius Brostrøm Kousgaard ◽  
Annette Sofie Davidsen
Keyword(s):  
Social Support ◽  
Qualitative Study ◽  
Case Management ◽  
Social Workers ◽  
Chronic Widespread Pain ◽  
Health Condition ◽  
Widespread Pain ◽  
Sickness Benefits ◽  
To Receive

People with chronic widespread pain (CWP) are often unfit for work, and consequently they are dependent on the municipality job center to receive social support and sickness benefits. The job center’s case management is based on a social worker’s assessment of the citizen’s health condition. This qualitative study investigates social workers’ understandings of CWP. Interviews were carried out with 12 social workers. The results showed that the participants predominantly experienced the citizens’ illnesses as psychosocially mediated—referring to trauma, or a lack of meaning in the citizens’ lives. Only a few participants mentioned possibilities for somatic explanations of CWP.

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