scholarly journals Symptom Clusters Change Over Time in Women Receiving Adjuvant Chemotherapy for Breast Cancer

2017 ◽  
Vol 53 (5) ◽  
pp. 880-886 ◽  
Author(s):  
Randa M. Albusoul ◽  
Ann M. Berger ◽  
Caryl L. Gay ◽  
Susan L. Janson ◽  
Kathryn A. Lee
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Symptom Clusters ◽  
Change Over Time ◽  
Over Time

Psychosocial outcomes following surgery in women with unilateral, nonhereditary breast cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 570-570
Author(s):  
David Wai Lim ◽  
Helene Retrouvey ◽  
Isabel Kerrebijn ◽  
Kate Butler ◽  
Anne C O'Neill ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Regression Model ◽  
Surgical Procedure ◽  
Psychosocial Outcomes ◽  
Well Being ◽  
Bilateral Mastectomy ◽  
Change Over Time ◽  
Younger Age ◽  
Unilateral Mastectomy ◽  
Over Time

570 Background: Rates of bilateral mastectomy continue to rise in average-risk women with unilateral breast cancer. We aim to characterize psychosocial predictors of surgical procedure and how psychosocial outcomes change over time after surgery for breast cancer. Methods: A prospective cohort of women with unilateral, nonhereditary breast cancer were recruited at University Health Network in Toronto, Canada between 2014-2017. Women completed validated psychosocial questionnaires (BREAST-Q) pre-operatively, and 6 and 12 months after surgery. Outcomes were assessed between three surgical groups (unilateral lumpectomy, unilateral mastectomy, bilateral mastectomy). Predictors of surgical procedure were identified using a multinomial logistic regression model. Change in psychosocial scores over time according to procedure was assessed using linear mixed models. All models control for age, stage, reconstruction and treatment. P values < .05 were considered statistically significant. Results: 506 women underwent surgery as follows: 216 unilateral lumpectomy (43%), 181 unilateral mastectomy (36%) and 109 bilateral mastectomy (22%). In the multinomial regression model, younger age (p < .01), and lower chest physical (p = .03) and sexual well-being (p = .02) predicted having bilateral mastectomy over unilateral lumpectomy while younger age (p < .01) and lower disease stage (p = .02) predicted bilateral mastectomy over unilateral mastectomy. The mixed model demonstrates that breast satisfaction follows a non-linear pattern of change over time, with 6- but not 12-month scores being significantly different from baseline (p = .015). Procedure predicts baseline satisfaction (p = .016), with bilateral mastectomy having worse satisfaction than unilateral lumpectomy. Procedure also predicts change in satisfaction, with unilateral and bilateral mastectomy having lower scores across time than lumpectomy. While a significant improvement in psychological well-being is detected by 12 months (p = .02), those with unilateral and bilateral mastectomy have worse psychological well-being over time compared to lumpectomy. Women having mastectomy start with worse physical well-being than those in the lumpectomy group, but their physical well-being does not decline as much as the lumpectomy group over time (p < .01). Conclusions: Definitive surgical procedure affects the trajectory of psychosocial functioning over time. This emerging data may be used to further facilitate surgical decision-making in women considering contralateral prophylactic mastectomy.

Symptom Clusters Change Over Time in Patients With Lung Cancer During Perichemotherapy

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nannan Li ◽  
Jing Wu ◽  
Jie Zhou ◽  
Caiqin Wu ◽  
Lu Dong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Symptom Clusters ◽  
Change Over Time ◽  
Over Time

scholarly journals Minimally Important Differences for Interpreting EORTC QLQ-C30 Scores in Patients With Advanced Breast Cancer

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Jammbe Z Musoro ◽  
Corneel Coens ◽  
Frederic Fiteni ◽  
Pogoda Katarzyna ◽  
Fatima Cardoso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Weighted Average ◽  
Advanced Breast ◽  
Life Questionnaire ◽  
Change Over Time ◽  
Eortc Qlq C30 ◽  
Group Change ◽  
Eortc Qlq ◽  
Over Time

Abstract Background We aimed to estimate the minimally important difference (MID) for interpreting group-level change over time, both within a group and between groups, for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in patients with advanced breast cancer. Methods Data were derived from two published EORTC trials. Clinical anchors (eg, performance status [PS]) were selected using correlation strength and clinical plausibility of their association with a particular QLQ-C30 scale. Three change status groups were formed: deteriorated by one anchor category, improved by one anchor category, and no change. Patients with greater anchor changes were excluded. The mean change method was used to estimate MIDs for within-group change, and linear regression was used to estimate MIDs for between-group differences in change over time. For a given QLQ-C30 scale, MID estimates from multiple anchors were triangulated to a single value via a correlation-based weighted average. Results MIDs varied by QLQ-C30 scale, direction (improvement vs deterioration), and anchor. MIDs for within-group change ranged from 5 to 14 points (improvement) and −14 to −4 points (deterioration), and MIDs for between-group change over time ranged from 4 to 11 points and from −18 to −4 points. Correlation-weighted MIDs for most QLQ-C30 scales ranged from 4 to 10 points in absolute values. Conclusions Our findings aid interpretation of changes in EORTC QLQ-C30 scores over time, both within and between groups, and for performing more accurate sample size calculations for clinical trials in advanced breast cancer.

scholarly journals Patterns of change over time and history of the inflammatory potential of diet and risk of breast cancer among postmenopausal women

2016 ◽  
Vol 159 (1) ◽  
pp. 139-149 ◽  
Author(s):  
Fred K. Tabung ◽  
Susan E. Steck ◽  
Angela D. Liese ◽  
Jiajia Zhang ◽  
Yunsheng Ma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Change Over Time ◽  
History Of ◽  
Over Time

scholarly journals Long-Term Favorable Effects of Physical Exercise on Burdensome Symptoms in the OptiTrain Breast Cancer Randomized Controlled Trial

2020 ◽  
Vol 19 ◽  
pp. 153473542090500
Author(s):  
Fleur Wiggenraad ◽  
Kate A. Bolam ◽  
Sara Mijwel ◽  
Elsken van der Wall ◽  
Yvonne Wengström ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Well Being ◽  
Physical Symptoms ◽  
Symptom Clusters ◽  
Breast Cancer Patients ◽  
Supervised Exercise

Purpose: We evaluate longitudinal changes in symptom clusters and core burdensome symptoms in breast cancer patients who participated in the OptiTrain trial. Methods: 240 women were randomized to 16 weeks of supervised exercise (RT-HIIT or AT-HIIT) or usual care (UC) during adjuvant chemotherapy. Symptom clusters were composed using the Memorial Symptom Assessment Scale (MSAS), assessed at baseline, 16 weeks and 12 months later. Three symptom clusters were formed. Results: Three symptom clusters were identified: “emotional,” “treatment-related toxicity,” and “physical,” with core burdensome symptoms present over time. At 16 weeks, the reported burdens of “feeling sad” (RT-HIIT vs UC: effect size [ES] = −0.69; AT-HIIT vs UC: ES = −0.56) and “feeling irritable” (ES = −0.41 RT-HIIT; ES = −0.31 AT-HIIT) were significantly lower in both intervention groups compared with UC. At 12 months, the AT-HIIT group continued to have significantly lower scores for the core burdensome symptoms “feeling sad” (ES = −0.44), “feeling irritable” (ES = −0.44), and “changes in the way food tastes” (ES = −0.53) compared with UC. No between-group differences were found for physical symptoms. Conclusion: We identified 3 symptom clusters in breast cancer patients during and after adjuvant chemotherapy, composed of “emotional,” “treatment-related toxicity,” and “physical” symptoms. After treatment completion up to 12 months post-baseline, patients in the physical exercise groups reported lower symptom burden scores for emotional symptoms, compared with UC. Our findings indicate a preserved and long-term beneficial effect of physical exercise on self-reported emotional well-being in chemotherapy-treated breast cancer patients.

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