Factors Associated With Attrition in a Multicenter Longitudinal Observational Study of Patients With Advanced Cancer

Background. Depression is a major reason for counselling in primary care. Our study aims at evaluating pharmacological treatment strategies among physicians specialised in anthroposophic medicine (AM).Methods. From 2004 to 2008, twenty-two German primary care AM-physicians participated in this prospective, multicentre observational study. Multiple logistic regression was used to determine factors associated with a prescription of any antidepressant medication.Results. A total of 2444 patients with depression were included (mean age: 49.1 years (SD: 15.4); 77.3% female). 2645 prescriptions of antidepressants for 833 patients were reported. Phytotherapeutic preparations fromHypericum perforatumwere the most frequently prescribed antidepressants over all (44.6% of all antidepressants), followed by amitriptyline (16.1%). The likelihood of receiving an antidepressant medication did not depend on comorbidity after controlling for age, gender, physician specialisation, and type of depression (adjusted OR(AOR)=1.01; CI: 0.81–1.26). Patients who had cancer were significantly less likely to be prescribed an antidepressant medication than those who had no cancer (AOR=0.75; CI: 0.57–0.97).Conclusion. This study provides a comprehensive analysis of everyday practice for the treatment of depression in AM -physicians. Further analysis regarding the occurrence of critical combinations is of high interest to health services research.

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Factors associated with prolonged duration of viral clearance in non-severe SARS-CoV-2 patients in Osaka, Japan

Environmental Health and Preventive Medicine ◽

10.1186/s12199-021-01035-y ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Emma Nakagawa Hoffman ◽

Haruna Kawachi ◽

Atsushi Hirayama ◽

Jingwen Zhang ◽

Ayumi Murayama ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Linear Regression ◽

Observational Study ◽

Symptom Onset ◽

Linear Regression Analysis ◽

Viral Clearance ◽

Factors Associated ◽

Longitudinal Observational Study ◽

Prolonged Duration

Abstract Background We investigated factors associated with prolonged viral clearance of SARS-CoV-2 among non-severe adult patients in Osaka, Japan. A total of 706 laboratory-confirmed COVID-19 patients were enrolled in this longitudinal observational study between 29 January 2020 and 31 May 2020, across 62 hospitals and three non-hospital recuperation facilities. Methods Logistic regression analysis was performed to investigate the factors associated with prolonged (29 days: upper 25% in duration) viral clearance of SARS-CoV-2. Linear regression analysis was conducted to assess these factors 14 days after symptom onset. Results The median duration of viral clearance was 22 days from symptom onset. After adjustment for sex, age, symptoms, comorbidity, and location of recuperation, comorbidities were associated with prolonged duration: (OR, 1.77 [95% CI, 1.11–2.82]) for one, (OR, 2.47 [95% CI, 1.32–4.61]) for two or more comorbidities. Viral clearance 14 days after symptom onset was 3 days longer for one comorbidity and 4 days longer for two or more comorbidities compared to clearance when there was no comorbidity. Conclusion The presence of comorbidity was a robust factor associated with a longer duration of viral clearance, extending by 3 to 4 days compared to patients with no comorbidity.

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The Association between Palliative Care Team Consultation and Hospital Care for Patients with Advanced Cancer: An Observational Study in 12 Dutch Hospitals

10.26226/morressier.5c76c8b5e2ea5a72376120bd ◽

2019 ◽

Author(s):

Arianne Brinkman-Stoppelenburg

Keyword(s):

Palliative Care ◽

Observational Study ◽

Advanced Cancer ◽

Hospital Care ◽

Palliative Care Team ◽

Care Team

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Risk factors associated with falls in persons with multiple sclerosis: an observational study

10.26226/morressier.5b719e445aff74008ae4ce94 ◽

2018 ◽

Author(s):

Zuhal Abasiyanik ◽

Turhan Kahraman ◽

Serkan Ozakbas

Keyword(s):

Risk Factors ◽

Multiple Sclerosis ◽

Observational Study ◽

Factors Associated

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ALTA TIPS: A 5-year Longitudinal Observational Study of Patients With Cirrhosis Undergoing TIPS Placement

Case Medical Research ◽

10.31525/ct1-nct03973372 ◽

2019 ◽

Author(s):

Keyword(s):

Observational Study ◽

Longitudinal Observational Study

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Comorbidity in Family Medicine - Causal or Casual? What is the Effect of Illness Diversity? A Longitudinal Observational Study in Primary Care

SSRN Electronic Journal ◽

10.2139/ssrn.3343649 ◽

2019 ◽

Author(s):

Jean Karl Soler ◽

Nicola Buono ◽

Inge Okkes

Keyword(s):

Primary Care ◽

Family Medicine ◽

Observational Study ◽

Longitudinal Observational Study

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The effect of COVID-19 pandemic and lockdown on consultation numbers, consultation reasons and performed services in primary care: results of a longitudinal observational study

BMC Family Practice ◽

10.1186/s12875-021-01471-3 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Ingmar Schäfer ◽

Heike Hansen ◽

Agata Menzel ◽

Marion Eisele ◽

Daniel Tajdar ◽

...

Keyword(s):

Primary Care ◽

Observational Study ◽

Rural Areas ◽

Longitudinal Observational Study ◽

Multivariable Analyses ◽

Gastrointestinal Complaints ◽

Urban And Rural Areas ◽

Quota Sampling ◽

Primary Care Practices

Abstract Objectives The aims of our study were to describe the effect of the COVID-19 pandemic and lockdown on primary care in Germany regarding the number of consultations, the prevalence of specific reasons for consultation presented by the patients, and the frequency of specific services performed by the GP. Methods We conducted a longitudinal observational study based on standardised GP interviews in a quota sampling design comparing the time before the COVID-19 pandemic (12 June 2015 to 27 April 2017) with the time during lockdown (21 April to 14 July 2020). The sample included GPs in urban and rural areas 120 km around Hamburg, Germany, and was stratified by region type and administrative districts. Differences in the consultation numbers were analysed by multivariate linear regressions in mixed models adjusted for random effects on the levels of the administrative districts and GP practices. Results One hundred ten GPs participated in the follow-up, corresponding to 52.1% of the baseline. Primary care practices in 32 of the 37 selected administrative districts (86.5%) could be represented in both assessments. At baseline, GPs reported 199.6 ± 96.9 consultations per week, which was significantly reduced during COVID-19 lockdown by 49.0% to 101.8 ± 67.6 consultations per week (p < 0.001). During lockdown, the frequency of five reasons for consultation (-43.0% to -31.5%) and eleven services (-56.6% to -33.5%) had significantly decreased. The multilevel, multivariable analyses showed an average reduction of 94.6 consultations per week (p < 0.001). Conclusions We observed a dramatic reduction of the number of consultations in primary care. This effect was independent of age, sex and specialty of the GP and independent of the practice location in urban or rural areas. Consultations for complaints like low back pain, gastrointestinal complaints, vertigo or fatigue and services like house calls/calls at nursing homes, wound treatments, pain therapy or screening examinations for the early detection of chronic diseases were particularly affected.

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What are the barriers to the completion of a home-based rehabilitation programme for patients awaiting surgery for lung cancer: a prospective observational study

BMJ Open ◽

10.1136/bmjopen-2020-041907 ◽

2021 ◽

Vol 11 (2) ◽

pp. e041907

Author(s):

Heloise Catho ◽

Sebastien Guigard ◽

Anne-Claire Toffart ◽

Gil Frey ◽

Thibaut Chollier ◽

...

Keyword(s):

Lung Cancer ◽

Observational Study ◽

Prospective Observational Study ◽

Living Alone ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Factors Associated ◽

Home Based ◽

Registration Number

ObjectivesHome-based rehabilitation programmes (H-RPs) could facilitate the implementation of pulmonary rehabilitation prior to resection for non-small cell lung cancer (NSCLC), but their feasibility has not been evaluated. The aim of this study was to identify determinants of non-completion of an H-RP and the factors associated with medical events occurring 30 days after hospital discharge.DesignA prospective observational study.InterventionAll patients with confirmed or suspected NSCLC were enrolled in a four-component H-RP prior to surgery: (i) smoking cessation, (ii) nutritional support, (iii) physiotherapy (at least one session/week) and (iv) home cycle-ergometry (at least three times/week).OutcomesThe H-RP was defined as ‘completed’ if the four components were performed before surgery.ResultsOut of 50 patients included, 42 underwent surgery (80% men; median age: 69 (IQR 25%–75%; 60–74) years; 64% Chronic Obstructive Pulmonary Disease (COPD); 29% type 2 diabetes). Twenty patients (48%) completed 100% of the programme. The median (IQR) duration of the H-RP was 32 (19; 46) days. Multivariate analysis showed polypharmacy (n=24) OR=12.2 (95% CI 2.0 to 74.2), living alone (n=8) (single vs couple) OR=21.5 (95% CI 1.4 to >100) and a long delay before starting the H-RP (n=18) OR=6.24 (95% CI 1.1 to 36.6) were independently associated with a risk of non-completion. In univariate analyses, factors associated with medical events at 30 days were H-RP non-completion, diabetes, polypharmacy, social precariousness and female sex.ConclusionFacing multiple comorbidities, living alone and a long delay before starting the rehabilitation increase the risk of not completing preoperative H-RP.Trial registration numberNCT03530059.

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