Calotropis belongs to two species, the majority of which are native to India, Indonesia, Malaysia, Thailand, and Sri Lanka. Calotropis
gigantea, also known as giant milk weed plant that grows in large quantities, is a member of the Apocynaceae (Asclepidiaceae) family
of latex-producing plants. Traditionally C. gigantea is used to treat a variety of diseases and ethno-medicinal claims. In the last few
decades, sophisticated analytical methods have been used to study C. gigantea for its medicinal properties and a number of bioactive
compounds have been isolated and analyzed from various parts of the plant. Analgesic, antimicrobial, antioxidant, anti-pyretic,
insecticidal, cytotoxic, hepatoprotective, pregnancy-interrupting, purgative, procoagulant, and wound-healing properties have been
identified and found to be effective which make it a valuable source of therapeutic compounds. This review attempts to cover
ethnobotany, pharmacology, phytochemistry, and phytopharmacological activities of C. gigantea.