Calotropis gigantea Linn. - An Indian Traditional Medicine Treasure

Calotropis belongs to two species, the majority of which are native to India, Indonesia, Malaysia, Thailand, and Sri Lanka. Calotropis gigantea, also known as giant milk weed plant that grows in large quantities, is a member of the Apocynaceae (Asclepidiaceae) family of latex-producing plants. Traditionally C. gigantea is used to treat a variety of diseases and ethno-medicinal claims. In the last few decades, sophisticated analytical methods have been used to study C. gigantea for its medicinal properties and a number of bioactive compounds have been isolated and analyzed from various parts of the plant. Analgesic, antimicrobial, antioxidant, anti-pyretic, insecticidal, cytotoxic, hepatoprotective, pregnancy-interrupting, purgative, procoagulant, and wound-healing properties have been identified and found to be effective which make it a valuable source of therapeutic compounds. This review attempts to cover ethnobotany, pharmacology, phytochemistry, and phytopharmacological activities of C. gigantea.

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Discovery of Channa striata extracts as regenerative medicine in promoting wound healing and scarless skin regeneration

The Natural Products Journal ◽

10.2174/2210315510999200629205601 ◽

2020 ◽

Vol 10 ◽

Author(s):

Soon Hong Kwan ◽

Mohd Nazri Ismail

Keyword(s):

Wound Healing ◽

Regenerative Medicine ◽

Traditional Medicine ◽

Modern Medicine ◽

Bioactive Molecules ◽

Therapeutic Effects ◽

Channa Striatus ◽

Wound Recovery ◽

Channa Striata ◽

Medicinal Properties

: Channa striata (also known as Channa striatus) is an air-breathing freshwater snakehead fish which is well known in the Asian region for its medicinal properties, particularly in wound healing. It is recognised as a traditional medicine (TM) which can be served as alternative treatment methods. With the advancement of technology, researchers have made a lot of progress in characterising the biomolecules of this fish. Various types of bioactive molecules have been identified in the fish, and their therapeutic effects are being studied.The C. striata have exhibited antibacterial, antinociceptive and effective wound recovery property through various pharmacology assays. It has been regarded as a source of traditional medicine which could complement modern medicine in promoting human health. The applications of C. striata extracts by practitioners in treating different illnesses are discussed. Besides, the approaches towards scarless wound in future applications involving the snakehead fish are also highlighted. Challenges and solutions to develop an aquatic-derived drug were also covered.The Channa striata extract as a natural product has shown great prospect for wound healing enhancement. Many biomolecules associated with antibacterial and antinociceptive properties, which are crucial for healthy wound recovery were identified in the species. Significant advances and researches in the region have successfully led to a better understanding of the species, which provide a promising future for drug development.

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Phytochemicals and Biological Activities of Barleria (Acanthaceae)

Plants ◽

10.3390/plants11010082 ◽

2021 ◽

Vol 11 (1) ◽

pp. 82

Author(s):

Serisha Gangaram ◽

Yougasphree Naidoo ◽

Yaser Hassan Dewir ◽

Salah El-Hendawy

Keyword(s):

Traditional Medicine ◽

Bioactive Compounds ◽

Biological Activities ◽

Acetylcholinesterase Activity ◽

Economic Importance ◽

Phenylethanoid Glycosides ◽

The Third ◽

The Family ◽

Medicinal Properties ◽

Seed Extracts

Plant species belonging to the family Acanthaceae are globally known to possess various medicinal properties and have cultural and economic importance in both traditional medicine and horticulture. They are important to both animals and humans and are used as food or for ornamental purposes worldwide. Barleria is the third largest genus in the family Acanthaceae. A few of the highly important and reported species of Barleria include B. prionitis, B. cristata, B. grandiflora, and B. lupulina. The flowers, leaves, stems, roots, and seed extracts of plants belonging to this genus are rich in bioactive compounds and have exhibited significant medicinal potential for the treatment of various ailments and infections. Evidence derived from several studies has demonstrated the antioxidant, antibacterial, antifungal, anti-inflammatory, anticancer, antidiabetic, antiulcer, hepatoprotective, analgesic, antiamoebic, antihelminthic, antiarthritic, antihypertensive, antiviral properties and toxicity of extracts, in addition inhibition of acetylcholinesterase activity and biosynthesis of nanoparticles, of the plant and seed extracts of species belonging to Barleria. Studies have reported that bioactive compounds such as flavonoids, quinones, iridoids, phenylethanoid glycosides, the immunostimulant protein “Sankaranin”, and antibiotics isolated from Barleria species are resposnsible for the above biological activities. Traditionally, the genus Barleria has significant medicinal potential; however, there is a scarcity of information on various species that are yet to be evaluated. This review provides a comprehensive report on existing literature, concerning the phytochemistry and biological activities of the genus Barleria.

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Medicinal Functions of Physalis Fruits for Biomedical Applications

Austin Journal of Medical Oncology ◽

10.26420/austinjmedoncol.2021.1061 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Abdel-Fattah WI ◽

◽

El-Bassyouni GT ◽

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Bioactive Compounds ◽

Antioxidant Properties ◽

Biologically Active ◽

Primary And Secondary Metabolites ◽

Physalis Peruviana ◽

Medicinal Value ◽

The Family ◽

Medicinal Properties

Drug innovation using natural products is an interesting mission for planning new leads. It describes the bioactive compounds resulting from natural resources, characterization and pharmacological examination. It emphases on the triumph of these resources in the process of finding and realizing new and effective drug compounds that can be beneficial for human resources. For medicinal devotions and for the progress of pharmaceutical substances, medicinal plants were used such as Physalis angulata L which is a medicinal plant used for numerous therapies including wound healing [1]. Physalis peruviana (golden berry) is an herbaceous annual plants belongs to the family Solanaceae [2]. This plant has a tremendous medicinal value for curing out different diseases: cancer, leukemia, diabetes, ulcers, malaria, asthma, hepatitis, dermatitis, rheumatism and several other diseases [3]. The golden berry fruit tastes like a sweet tomato and includes high levels of vitamin C, vitamin A and the vitamin B-complex. The fruit was demonstrated to have both antiinflammatory and antioxidant properties [4,5]. Herbal specialists and local people of several countries have used many extracts of medicinal plants to achieve and treat various diseases comprising wound healing [6]. Physalis with its notable benefits related to high nutrients and bioactive compounds with extraordinary antioxidant activity and other several medicinal properties have been ascribed to these compounds [7,8]. The bioactive compounds are formed as primary and secondary metabolites of the fruits. These compounds are biologically active with cytotoxic, antimicrobial, antioxidant, antiviral, fungicidal, insecticidal, tranquilizing, analgesic, anti-inflammatory, and contraceptive actions, among others. Such compounds are used for several dedications, such as in medical therapy, to cure diseases, in the cosmetics, and in the food industry as antioxidants or flavorings [9] (Figure 1).

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Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Antibiotics ◽

10.3390/antibiotics10030248 ◽

2021 ◽

Vol 10 (3) ◽

pp. 248

Author(s):

Marta O. Teixeira ◽

Joana C. Antunes ◽

Helena P. Felgueiras

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Mechanical Stability ◽

Fiber Spinning ◽

Comprehensive Overview ◽

Triggered Drug Release ◽

Medicinal Properties ◽

Hydrogel Composites ◽

Drug Incorporation ◽

Stimuli Sensitive

In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

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The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

Molecules ◽

10.3390/molecules26020382 ◽

2021 ◽

Vol 26 (2) ◽

pp. 382

Author(s):

Barbara Pacholczyk-Sienicka ◽

Grzegorz Ciepielowski ◽

Łukasz Albrecht

Keyword(s):

Quality Assurance ◽

Nmr Spectroscopy ◽

Sample Preparation ◽

Bioactive Compounds ◽

Analytical Methods ◽

Structural Information ◽

Chemometric Analysis ◽

Spectroscopic Methods ◽

Regular Consumption ◽

No Sample Preparation

Spices and herbs are among the most commonly adulterated food types. This is because spices are widely used to process food. Spices not only enhance the flavor and taste of food, but they are also sources of numerous bioactive compounds that are significantly beneficial for health. The healing effects of spices are connected with their antimicrobial, anti-inflammatory and carminative properties. However, regular consumption of adulterated spices may cause fatal damage to our system because adulterants in most cases are unhealthy. For that reason, the appropriate analytical methods are necessary for quality assurance and to ensure the authenticity of spices. Spectroscopic methods are gaining interest as they are fast, require little or no sample preparation, and provide rich structural information. This review provides an overview of the application of NMR spectroscopy combined with chemometric analysis to determine the quality and adulteration of spices.

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