Volumetric Absorptive Microsampling (VAMS) for assaying immunosuppressants from venous whole blood by LC–MS/MS using a novel atmospheric pressure ionization probe (UniSpray™)

2020 ◽  
Vol 189 ◽  
pp. 113422 ◽  
Author(s):  
Lucía Paniagua-González ◽  
Carla Díaz-Louzao ◽  
Elena Lendoiro ◽  
Esteban Otero-Antón ◽  
Carmen Cadarso-Suárez ◽  
...  
Keyword(s):  
Whole Blood ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Ionization ◽  
Ionization Probe ◽  
Volumetric Absorptive Microsampling

scholarly journals Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 262
Author(s):  
Camilla Marasca ◽  
Maria Encarnacion Blanco Arana ◽  
Michele Protti ◽  
Andrea Cavalli ◽  
Laura Mercolini ◽  
...  
Keyword(s):  
High Resolution ◽  
Whole Blood ◽  
Chemical Space ◽  
Solid Support ◽  
Dried Blood Spot ◽  
Proof Of Concept ◽  
Viable Option ◽  
Human Whole Blood ◽  
Blood Spot ◽  
Volumetric Absorptive Microsampling

In the present, proof-of-concept paper, we explore the potential of one common solid support for blood microsampling (dried blood spot, DBS) and a device (volumetric absorptive microsampling, VAMS) developed for the untargeted lipidomic profiling of human whole blood, performed by high-resolution LC-MS/MS. Dried blood microsamples obtained by means of DBS and VAMS were extracted with different solvent compositions and compared with fluid blood to evaluate their efficiency in profiling the lipid chemical space in the most broad way. Although more effort is needed to better characterize this approach, our results indicate that VAMS is a viable option for untargeted studies and its use will bring all the corresponding known advantages in the field of lipidomics, such as haematocrit independence.

Characterization of HOCl Using Atmospheric Pressure Ionization Mass Spectrometry

1999 ◽  
Vol 103 (41) ◽  
pp. 8231-8238 ◽  
Author(s):  
Tracy E. Caldwell ◽  
K. L. Foster ◽  
Thorsten Benter ◽  
Sarka Langer ◽  
John C. Hemminger ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Atmospheric Pressure ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Atmospheric Pressure Ionization ◽  
Pressure Ionization Mass Spectrometry
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