Development and validation of a UPLC-MS/MS method to quantitate anti-PD1 monoclonal antibody (Toripalimab), and comparison with electrochemiluminescence immunoassay

2021 ◽  
pp. 114515
Author(s):  
Shuxia Liu ◽  
Jianliang Yang ◽  
Sheng Yang ◽  
Qiaoyun Tan ◽  
Liyuan Dai ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Electrochemiluminescence Immunoassay ◽  
Development And Validation

Abstract 4595: Development and validation of a novel EGF receptor-neutralizing monoclonal antibody

2016 ◽  
Author(s):  
Krystyna Zuberek Hincman ◽  
Christopher A. Manning ◽  
Michael R. Nelson ◽  
Michael Lewis ◽  
Roy Scialdone ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Egf Receptor ◽  
Neutralizing Monoclonal Antibody ◽  
Development And Validation

scholarly journals Development and validation of a direct competitive monoclonal antibody-based immunoassay for the sensitive and selective analysis of the phytoregulator forchlorfenuron

2012 ◽  
Vol 403 (7) ◽  
pp. 2019-2026 ◽  
Author(s):  
Celia Suárez-Pantaleón ◽  
Francesc A. Esteve-Turrillas ◽  
Josep V. Mercader ◽  
Consuelo Agulló ◽  
Antonio Abad-Somovilla ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Development And Validation ◽  
Selective Analysis

Development and Validation of Monoclonal Antibody-Based Antigen Capture ELISA for Detection of Group A Porcine Rotavirus

2017 ◽  
Vol 30 (4) ◽  
pp. 264-270 ◽  
Author(s):  
Atta Muhammad Memon ◽  
Anjuman Ara Bhuyan ◽  
Fangzhou Chen ◽  
Xiaozhen Guo ◽  
Harish Menghwar ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Capture Elisa ◽  
Antigen Capture Elisa ◽  
Antigen Capture ◽  
Group A ◽  
Development And Validation ◽  
Porcine Rotavirus

scholarly journals Development and validation of a method for the determination of the specific activity of recombinant monoclonal antibody eculizumab

2020 ◽  
Vol 15 (2) ◽  
pp. 77-85
Author(s):  
D. I. Zybin ◽  
A. S. Seregin ◽  
A. D. Askretkov ◽  
N. V. Orlova ◽  
Yu. A. Seregin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Pharmaceutical Analysis ◽  
Comparative Evaluation ◽  
Specific Activity ◽  
In Vitro Method ◽  
Recombinant Monoclonal Antibody ◽  
Development And Validation ◽  
First Time

Objectives. Developing reliable and accurate analytical methods is necessary for comparative pharmaceutical analysis using physicochemical, biological (in vitro), preclinical, and clinical trials. The main objective of this study was to develop and validate an in vitro method for determining the specific activity of the recombinant monoclonal antibody eculizumab.Methods. The method of indirect enzyme immunoassay was used in the study.Results. A method for determining the specific activity of the humanized recombinant monoclonal antibody eculizumab was described and validated for the first time. A comparative evaluation of the specific activity of Soliris® (Alexion Pharmaceuticals Inc., USA), and its biosimilar PRK-001 (Pharmapark, Russia) was performed using the developed method.Conclusions. The similarity of PRK-001 and the original Soliris® in relation to their specific activity, that is, binding to the human complement system C5 protein, was proved. 

scholarly journals Erratum to: Development and validation of H11B2C2 monoclonal antibody-reactive hyaluronic acid binding protein:overexpression of HABP during human tumor progression

Tumor Biology ◽  
2012 ◽  
Vol 34 (1) ◽  
pp. 609-609
Author(s):  
Rajeev K. Boregowda ◽  
Hitesh N. Appaiah ◽  
Mortha Karunakumar ◽  
Shivanna Parameshwariah ◽  
Geetha Avadani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Hyaluronic Acid ◽  
Tumor Progression ◽  
Human Tumor ◽  
Development And Validation ◽  
Hyaluronic Acid Binding
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