scholarly journals Optimizing bone health in Brazilian teens: using a population‐based survey to guide targeted interventions to increase dietary calcium intake

2016 ◽  
Vol 92 (3) ◽  
pp. 220-222
Author(s):  
Neville H. Golden
2019 ◽  
Vol 106 (2) ◽  
pp. 104-114 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Katerina Trajanoska ◽  
Fjorda Koromani ◽  
Fernando Rivadeneira ◽  
...  

Abstract Loop diuretics (LD) may affect bone health by inhibiting renal calcium reuptake. However, whether vitamin D status and dietary calcium intake modify the association between LD and bone outcome is unclear. Therefore, this study aimed to evaluate whether vitamin D level or calcium intake modify the association between LD and various indices of bone health including bone mineral density (BMD) and Trabecular Bone Score (TBS). From The Rotterdam Study, a prospective population-based cohort study, we used data from 6990 participants aged > 45 year with a DXA scan (2002–2008), 6908 participants with femoral neck (FN)-BMD, 6677 participants with lumbar spine (LS)-BMD and 6476 participants with LS-TBS measurements. Use of LD was available from pharmacy dispensing records. Vitamin D (25(OH)D) level was measured in serum, and dietary calcium intake was measured with a validated food frequency questionnaire. Almost eight percent of the participants used LD. The association between LD (past-users compared to never-users) and LS-TBS was significantly different by 25(OH)D concentrations (P for interaction = 0.04). A significantly lower LS-TBS among LD past-users was observed for 25(OH)D ≥ 50 nmol/l compared to ≤ 20 and 20–50 nmol/l (β = − 0.036, 95% CI − 0.060; − 0.013 vs. β = − 0.012, 95% CI − 0.036; 0.013 and β = − 0.031, 95% CI − 0.096; 0.034, respectively). However, no other significant effect modification by 25(OH)D and dietary calcium intake was found in the associations between LD use and bone health outcomes (P-interaction > 0.13). This study suggests that the association between LD use and indices of bone health is not consistently modified by vitamin D or dietary calcium intake.


Author(s):  
Nicola M Lowe ◽  
Basma Ellahi ◽  
Qudsia Bano ◽  
Sonia Ali Bangash ◽  
Soma R Mitra ◽  
...  

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Zhe Wang ◽  
Min Hao ◽  
Aimin Yang ◽  
Wenhao Wang ◽  
Yueyang Zhao ◽  
...  

Abstract Objectives Diet plays a significant role in the carcinogenesis. However, few studies had been conducted to evaluate the association of dietary mineral intake and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer among community-based Chinese women. Methods We performed a cross-sectional analysis of screening data in 2304 women in an ongoing cohort of 40,000 women in China. Multivariable logistic regressions were modeled to evaluate the relationship between dietary mineral intake and CIN + risk. Results After adjusting for multiple confounders, several dietary minerals intake were significantly associated with CIN2 + risk. Dietary calcium intake concentration was associated with the risk of CIN2 + (1st quartile versus 4th quartile: OR = 1.52, 95% CI: 1.01–2.32). The similar results were also observed for magnesium (OR = 1.80, 95% CI: 1.20–2.68), phosphorus (OR = 1.69, 95% CI: 1.12–2.55), zinc (OR = 1.55, 95% CI: 1.03–2.34) and potassium (OR = 1.92, 95% CI: 1.28–2.88). The association between dietary calcium intake and CIN1 risk (2nd quartile compared with 4th quartile: OR = 1.36, 95% CI: 1.03, 1.80), potassium (OR = 1.90, 95% CI: 1.27, 2.85). However, seldom statistical association was observed between other dietary mineral intake and CIN1 risk. Conclusions Dietary nutrients such as calcium, magnesium, phosphorus, zinc, and potassium were associated with risk of CIN2+, supporting the hypothesis that dietary mineral intake play a role in the development of higher grad CIN and cervical cancer. Funding Sources This study is supported by the Special Public Welfare Industry Research of National Health and Family Planning Commission of China (grant 201402010); This study is supported by the applied basic research project of Shanxi province (grant 201601D011086). Supporting Tables, Images and/or Graphs


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