scholarly journals Metabolic Bone Disease and Bone Mineral Density in Very Preterm Infants

2014 ◽  
Vol 164 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Josep Figueras-Aloy ◽  
Enriqueta Álvarez-Domínguez ◽  
José M. Pérez-Fernández ◽  
Gloria Moretones-Suñol ◽  
Sergi Vidal-Sicart ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Preterm Infants ◽  
Bone Mineral ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Mineral Density ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Metabolic Bone

scholarly journals Early Nutrition during Hospitalization in Relation to Bone Health in Preterm Infants at Term Age and Six Months Corrected Age

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1192
Author(s):  
Alexandra K. Calor ◽  
Dana F. J. Yumani ◽  
Mirjam M. van Weissenbruch
Keyword(s):  
Preterm Infants ◽  
Bone Mineral ◽  
Bone Health ◽  
Nutritional Intervention ◽  
Whole Body ◽  
Macronutrient Intake ◽  
Fat Intake ◽  
Mineral Density ◽  
Very Preterm Infants ◽  
Very Preterm

Aim: to evaluate the potential association of macronutrient intake in the first postnatal weeks on bone mineral content (BMC) and bone mineral density (BMD) in extremely and very preterm infants. Methods: fifty-eight extremely and very preterm infants were included. Daily macronutrient intake was calculated in g kg−1 day−1 from birth up to 36 weeks postmenstrual age. A dual-energy X-ray absorptiometry whole body scan was used to assess BMC and BMD in preterm infants at term corrected age (TCA) and six months corrected age (CA). Results: fat intake (g kg−1 day−1) in the first four postnatal weeks was positively associated with BMC and BMD at TCA. At six months CA, protein and fat intake (g kg−1 day−1) in the first weeks of life were both individual predictors for BMD. Fat intake (g kg−1 day−1) in the first four postnatal weeks was significantly associated with BMC at six months CA. Conclusion: the association of macronutrient intake in the first postnatal weeks on BMC or BMD, at TCA and six months CA, suggest that early nutritional intervention immediately after birth and during early infancy is important for bone health in the first months of life.

scholarly journals Hypophosphatemia in the setting of metabolic bone disease: case reports and diagnostic algorithm

2018 ◽  
Vol 10 (7) ◽  
pp. 151-156 ◽  
Author(s):  
Alvin Lee Day ◽  
Sarah L. Morgan ◽  
Kenneth G. Saag
Keyword(s):  
Bone Mineral ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Case Reports ◽  
Diagnostic Algorithm ◽  
Mineral Density ◽  
Spot Urine ◽  
Metabolic Bone ◽  
Disease Case ◽  
Osteoporosis Clinic

Osteoporosis is the most commonly encountered metabolic bone disease, and metabolic bone-disease clinics have been established to assist in the diagnosis and treatment of uncommon causes of low bone-mineral density. Hypophosphatemia leading to metabolic bone disease may be encountered, and an understanding of phosphate homeostasis can aid in the diagnosis. Two cases of hypophosphatemia leading to low bone-mineral densities were seen at the University of Alabama at Birmingham Osteoporosis Clinic. We developed a diagnostic algorithm, and the laboratory values of each patient were tested with the algorithm. The algorithm, incorporating the use of a spot urine phosphate and spot urine creatinine level at the time of initial serum metabolic profile evaluation, accurately determined the cause of hypophosphatemia in each case.

scholarly journals Bone Mineral Density, Body Composition, and Metabolic Health of Very Low Birth Weight Infants Fed in Hospital Following Current Macronutrient Recommendations during the First 3 Years of Life

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1005
Author(s):  
Walter Mihatsch ◽  
Izaskun Dorronsoro Martín ◽  
Vicente Barrios-Sabador ◽  
María L. Couce ◽  
Gabriel Á. Martos-Moreno ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Health Outcome ◽  
Body Composition ◽  
Preterm Infants ◽  
Bone Mineral ◽  
Very Low Birth Weight ◽  
Metabolic Health ◽  
Mineral Density ◽  
Term Infants ◽  
Vlbw Infants

The present study longitudinally evaluated growth, bone mineral density, body composition, and metabolic health outcome in very low birth weight (VLBW) infants whose in-hospital target nutrient intake was within recent recommendations. From six months to three years, bone mineral density (dual-energy X-ray absorptiometry, DXA), body composition, and metabolic health outcome were compared with a reference group of term infants. The aim was to test whether in-hospital achieved weight gain until 36 weeks of gestation (light or appropriate for term equivalent age; LTEA or ATEA) predicts later growth, bone mineral density (BMD), abdominal obesity, or metabolic health outcomes such as insulin resistance, relative to term infants, during the first three years of life. Target in-hospital energy and protein intake was not achieved. Growth in weight, length and head circumference, mid arm circumference, adiposity, fat free mass (FFM), and bone mineralization in VLBW infants was less than those in term infants and influenced by nutritional status at discharge. Preterm infants had poorer motor and cognitive outcomes. Post-discharge body composition patterns indicate FFM proportional to height but lower fat mass index in LTEA preterm infants than term infants, with no evidence of increased truncal fat in preterm infants. The hypothesis of early BMD catch-up in VLBW infants after discharge was not supported by the present data. The clinical significance of these findings is unclear. The data may suggest a reduced obesity risk but an increased osteoporosis risk. Since postnatal growth restriction may have permanent negative health effects, LTEA VLBW infants would especially appear to benefit from targeted preventive interventions. Further follow-up of the infants is required.

scholarly journals Metabolic bone disease in preterm infants.

1985 ◽  
Vol 60 (7) ◽  
pp. 682-685 ◽  
Author(s):  
O G Brooke ◽  
A Lucas
Keyword(s):  
Preterm Infants ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Metabolic Bone

scholarly journals PREVALENCE OF OSTEOPOROSIS AND HYPOVITAMINOSIS D AT SIRIRAJ METABOLIC BONE DISEASE CLINIC

2017 ◽  
Vol 25 (6) ◽  
pp. 262-265
Author(s):  
AASIS UNNANUNTANA ◽  
POJCHONG CHOTIYARNWONG
Keyword(s):  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Fragility Fractures ◽  
Hypovitaminosis D ◽  
Mineral Density ◽  
Baseline Serum ◽  
Metabolic Bone ◽  
Vitamin D Levels ◽  
History Of ◽  
Prevalence Of Osteoporosis

ABSTRACT Objective: To identify the prevalence of osteoporosis and hypovitaminosis D among patients at the Siriraj Metabolic Bone Disease (MBD) Clinic, and to compare initial vitamin D levels in patients with and without a history of fragility fractures. Methods: Medical records of patients who attended our MBD clinic between 2012 and 2015 were retrospectively reviewed. Patient baseline demographic, clinical, bone mineral density (BMD), and laboratory data were collected and analyzed. Osteoporosis was diagnosed when patients had a BMD T-score <-2.5 or presented with fragility fractures. Results: There were 761 patients included in this study. Of these, 627 patients (82.4%) were diagnosed with osteoporosis and 508 patients (66.8%) had fragility fractures. Baseline serum 25-hydroxyvitamin D (25(OH)D) levels were available in 685 patients. Of these, 391 patients (57.1%) were diagnosed with hypovitaminosis D. When evaluated only in patients with fragility fractures, the average initial 25(OH)D level was 28.2±11.6 ng/mL, and the prevalence of hypovitaminosis D was 57.6%. Conclusion: A high prevalence of osteoporosis and hypovitaminosis D was found among patients at our clinic; two-thirds of patients had a history of fragility fractures, and no difference in initial 25(OH)D levels was seen between patients with and without fragility fractures. Level of Evidence III, Retrospective Study .

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