Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin

Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially in infants with advanced disease. The mechanism of disease development, the progression of intestinal injury, and management remain areas of ongoing research and controversy. In this review, we examine our current understanding of the disease, its epidemiology, the risk factors associated with the development of the disease, and its pathophysiology. We also describe current management and new emerging research highlighting potential future directions.

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Prevalence, mortality and risk factors associated with very low birth weight preterm infants: an analysis of 33 years

Jornal de Pediatria (Versão em Português) ◽

10.1016/j.jpedp.2019.04.006 ◽

2020 ◽

Vol 96 (3) ◽

pp. 327-332

Author(s):

Julia Damiani Victora ◽

Mariangela Freitas Silveira ◽

Cristian Tedesco Tonial ◽

Cesar Gomes Victora ◽

Fernando Celso Barros ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Very Low Birth Weight ◽

Factors Associated

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Neurodevelopmental and growth outcomes of extremely preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation

Journal of Pediatric Surgery ◽

10.1016/j.jpedsurg.2020.05.013 ◽

2020 ◽

Cited By ~ 2

Author(s):

Carlos Zozaya ◽

Jyotsna Shah ◽

Agostino Pierro ◽

Augusto Zani ◽

Anne Synnes ◽

...

Keyword(s):

Preterm Infants ◽

Necrotizing Enterocolitis ◽

Intestinal Perforation ◽

Growth Outcomes ◽

Extremely Preterm ◽

Extremely Preterm Infants ◽

Spontaneous Intestinal Perforation

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Preeclampsia is an independent risk factor for spontaneous intestinal perforation in very preterm infants

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2013.851189 ◽

2013 ◽

Vol 27 (12) ◽

pp. 1248-1251

Author(s):

Yavuz Yılmaz ◽

H. Gözde Kanmaz Kutman ◽

Hülya Özkan Ulu ◽

F. Emre Canpolat ◽

Nurdan Uraş ◽

...

Keyword(s):

Risk Factor ◽

Preterm Infants ◽

Intestinal Perforation ◽

Independent Risk Factor ◽

Very Preterm Infants ◽

Very Preterm ◽

Spontaneous Intestinal Perforation

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Antenatal Exposure to Magnesium Sulfate and Spontaneous Intestinal Perforation and Necrotizing Enterocolitis in Extremely Preterm Neonates

American Journal of Perinatology ◽

10.1055/s-0037-1603344 ◽

2017 ◽

Vol 34 (12) ◽

pp. 1227-1233 ◽

Cited By ~ 5

Author(s):

Mohamed Shalabi ◽

Adel Mohamed ◽

Brigitte Lemyre ◽

Khalid Aziz ◽

Daniel Faucher ◽

...

Keyword(s):

Magnesium Sulfate ◽

Preterm Infants ◽

Necrotizing Enterocolitis ◽

Intestinal Perforation ◽

Preterm Neonates ◽

Network Database ◽

Extremely Preterm ◽

Extremely Preterm Infants ◽

Using Data ◽

Spontaneous Intestinal Perforation

Background There have been recent concerns regarding the higher rates of spontaneous intestinal perforation (SIP) in preterm infants that have been exposed to intrapartum magnesium sulfate (MgSO4). Objective To assess the association between intrapartum MgSO4 exposure and necrotizing enterocolitis (NEC) and/or SIP in extremely preterm neonates. Design A retrospective cohort study was conducted using data from the Canadian Neonatal Network database. Infants born at < 28 weeks' gestation admitted to neonatal units in Canada between 2011 and 2014 were divided into two groups: those exposed antenatally to MgSO4 and those unexposed. Stratified analyses for infants born between 22 and 25 weeks' gestation and those born between 26 and 27 weeks' gestation were conducted. The primary outcome was intestinal injury, identified as either NEC or SIP. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression. Results We compared 2,300 unexposed infants with 2,055 exposed infants. There was no difference in the odds of NEC (9.88% exposed vs. 9.59% unexposed; aOR: 0.92; 95% CI: 0.75–1.14) or SIP (3.4% exposed vs. 3.39% unexposed; aOR: 1.05; 95% CI: 0.75–1.48) between the two groups. Conclusion Antenatal exposure to MgSO4 was not associated with NEC or SIP in extremely preterm infants.

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