Risk Factors Associated with Intraventricular Hemorrhage in Preterm Infants with ≤28 Weeks Gestational Age

2016 ◽  
Vol 228 (05) ◽  
pp. 245-250 ◽  
Author(s):  
M. Waitz ◽  
S. Nusser ◽  
M. Schmid ◽  
J. Dreyhaupt ◽  
F. Reister ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Gestational Age ◽  
Intraventricular Hemorrhage ◽  
Factors Associated

scholarly journals Risk factors for the development of intraventricular hemorrhage in preterm infants with respiratory distress syndrome

2021 ◽  
Vol 66 (5) ◽  
pp. 49-55
Author(s):  
A. V. Andreev ◽  
N. V. Kharlamova ◽  
N. A. Shilova ◽  
A. A. Pesenkina
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Gestational Age ◽  
Intraventricular Hemorrhage ◽  
Distress Syndrome ◽  
Significant Risk ◽  
Group I

Intraventricular hemorrhage remains a serious complication in infants and especially in preterm infants with gestational age up to 27 weeks.Objective. To assess the risk factors for the development of intraventricular hemorrhage in deeply preterm infants with respiratory distress syndrome.Materials and methods. We carried out a prospective controlled comparative study. The study included 104 newborns with respiratory distress syndrome with a gestational age of less than 32 weeks and a birth weight of less than 1500 g. Depending on the presence of intraventricular hemorrhage the patients were divided into groups: Group I : 56 preterm infants with intraventricular hemorrhage verified during the observation; Group II: 48 preterm infants without intraventricular hemorrhageResults. The groups at birth were comparable in terms of weight and height. We identified the risk factors contributing to the development of intraventricular hemorrhage: the absence of antenatal prophylaxis of fetal respiratory distress syndrome (odds ratio (OR) 2.728; 95% CI 1.218–6.109), tracheal intubation in the delivery room (OR 5.714; 95% CI 1.610–20.28), the need for mechanical ventilation on the first day life (OR 2.713; 95% CI 1.154–6.377), forced mechanical ventilation (OR 9.818; 95% CI 1.039–92.86), > 20 manipulations in the first day of life (OR 2.747; 95% CI 1.240–6.089). Also, the authors determined the factors contributing to a decrease in the development of intraventricular hemorrhage: complete antenatal prevention of fetal respiratory distress syndrome (OR 0.35; 95% CI 0.149–0.825), less invasive administration of poractant-alpha at a dosage of 200 mg/kg (OR 0.161; 95% CI 0.033–0.787), ventilation with double control during inspiration (OR 0.159; 95% CI 0.032–0.784), chronic arterial hypertension in the mother during the present pregnancy (OR 0.185; 95% CI 0.037–0.919).Conclusion. According to the results of the study the authors identified significant risk factors for the development of intraventricular hemorrhage in deeply preterm infants with respiratory distress syndrome.

72 Identifying Perinatal and Neonatal Factors Associated with Autism Spectrum Disorder among Preterm Infants Born < 29 Weeks’ Gestation

2021 ◽  
Vol 26 (Supplement_1) ◽  
pp. e51-e53
Author(s):  
Andrée-Anne Busque ◽  
Elias Jabbour ◽  
Sharina Patel ◽  
Élise Couture ◽  
Jarred Garfinkle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Preterm Infants ◽  
Gestational Age ◽  
Developmental Outcomes ◽  
Autism Spectrum ◽  
Economic Factors ◽  
Factors Associated ◽  
Socio Economic Factors

Abstract Primary Subject area Neonatal-Perinatal Medicine Background Preterm infants born &lt;29 weeks’ gestational age (GA) are at risk for autism spectrum disorder (ASD), typically diagnosed at age &gt;2 years. Perinatal and neonatal factors, including interventions and morbidities during neonatal intensive care unit admission, may contribute to the risk of ASD among these infants. Objectives We aimed to assess the incidence of and risk factors for, ASD among preterm infants born &lt; 29 weeks’ GA. Design/Methods &lt;29 weeks’ GA admitted 2009-2017 to two tertiary NICUs and followed ≥18 months at the Neonatal Follow-Up Clinic. Primary outcome was ASD defined as a confirmed diagnosis using standardized testing or suspected diagnosis at &gt;18 months of corrected age. Patient data and 18-month developmental outcomes were obtained from the local Canadian Neonatal Follow Up Network database and from chart review. Stepwise logistic regression was used to identify significant perinatal, neonatal, and socio-economic factors associated with ASD. Results Among 300 eligible infants, 47 (15.7%) developed ASD (Figure 1, Table 1). Mean follow-up duration was 3.9 ± 1.4 years and mean age at diagnosis was 3.7 ± 1.5 years. Male sex (adjusted odds ratio [aOR] 4.63, 95% CI 2.12, 10.10), small for gestational age status (aOR 3.03, 95% CI 1.02, 9.01), maternal age ≥ 35 years at delivery (aOR 2.22, 95% CI 1.08, 4.57), and tobacco use in utero (aOR 5.67, 95% CI 1.86, 17.29) were significantly associated with ASD. Major neonatal morbidities (retinopathy of prematurity, bronchopulmonary dysplasia, necrotizing enterocolitis, late-onset sepsis, severe neurological injury) were not associated with ASD. Among infants with a complete 18-month corrected age developmental assessment and later diagnosed with ASD, 46% (19/41) did not have significant neurodevelopment impairment (Bayley-III &lt; 70, deafness, blindness, or cerebral palsy). Conclusion ASD is a significant morbidity among infants born &lt; 29 weeks’ GA. ASD was associated with infant and prenatal risk factors but not with neonatal morbidities or socio-economic factors. These findings emphasize the need for ASD evaluation among preterm infants &lt; 29 weeks and for reporting developmental outcomes beyond 18-months corrected age.

scholarly journals Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 420
Author(s):  
Claudia Ioana Borțea ◽  
Florina Stoica ◽  
Marioara Boia ◽  
Emil Radu Iacob ◽  
Mihai Dinu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Surfactant Administration ◽  
Stage 1

Background and Objectives: Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm infants. We studied the relationship between different perinatal characteristics, i.e., sex; gestational age (GA); birth weight (BW); C-reactive protein (CRP) and lactate dehydrogenase (LDH) concentrations; ventilation, continuous positive airway pressure (CPAP), and surfactant administration; and the incidence of Stage 1–3 ROP. Materials and Methods: This study included 247 preterm infants with gestational age (GA) < 32 weeks that were successfully screened for ROP. Univariate and multivariate binary analyses were performed to find the most significant risk factors for ROP (Stage 1–3), while multivariate multinomial analysis was used to find the most significant risk factors for specific ROP stages, i.e., Stage 1, 2, and 3. Results: The incidence of ROP (Stage 1–3) was 66.40% (164 infants), while that of Stage 1, 2, and 3 ROP was 15.38% (38 infants), 27.53% (68 infants), and 23.48% (58 infants), respectively. Following univariate analysis, multiple perinatal characteristics, i.e., GA; BW; and ventilation, CPAP, and surfactant administration, were found to be statistically significant risk factors for ROP (p < 0.001). However, in a multivariate model using the same characteristics, only BW and ventilation were significant ROP predictors (p < 0.001 and p < 0.05, respectively). Multivariate multinomial analysis revealed that BW was only significantly correlated with Stage 2 and 3 ROP (p < 0.05 and p < 0.001, respectively), while ventilation was only significantly correlated with Stage 2 ROP (p < 0.05). Conclusions: The results indicate that GA; BW; and the use of ventilation, CPAP, and surfactant were all significant risk factors for ROP (Stage 1–3), but only BW and ventilation were significantly correlated with ROP and specific stages of the disease, namely Stage 2 and 3 ROP and Stage 2 ROP, respectively, in multivariate models.

Antenatal Risk Factors Associated with Spontaneous Intestinal Perforation in Preterm Infants Receiving Postnatal Indomethacin

2021 ◽  
Author(s):  
Tamara I. Arnautovic ◽  
Jami L. Longo ◽  
Elizabeth J. Trail-Burns ◽  
Richard Tucker ◽  
Martin Keszler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Intestinal Perforation ◽  
Factors Associated ◽  
Spontaneous Intestinal Perforation

scholarly journals 1271 Risk Factors for Intraventricular Hemorrhage in Less Than 32 Weeks Gestation Preterm Infants - Prospective Study

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A363-A363
Author(s):  
M. Ognean ◽  
E. Olariu ◽  
O. Boanta ◽  
A. Nicula ◽  
V. Panait ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage

Disseminated Candidal Infections and Intravenous Hydrocortisone in Preterm Infants

PEDIATRICS ◽  
1995 ◽  
Vol 95 (6) ◽  
pp. 883-887
Author(s):  
Carlos M. Botas ◽  
Isabel Kurlat ◽  
Shirley M. Young ◽  
Augusto Sola
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Birth Weight ◽  
San Francisco ◽  
Preterm Infants ◽  
Gestational Age ◽  
Selection Process ◽  
Control Group ◽  
Major Teaching Hospital ◽  
Intensive Care Nursery

Background. Intravenous (IV) hydrocortisone (HC) has been used recently in selected preterm infants for hypotension soon after birth. During the same time period that HC was used, there was a marked increase in the incidence of disseminated candidal infections (DCIs). Objective. To determine whether there is an association between DCI in the first 35 days of life and IV HC in preterm infants. Research design. A hospital case-control study comparing the exposure of HC between preterm infants with DCI and matched infants without DCI. Setting. A tertiary level intensive care nursery in a major teaching hospital in San Francisco, CA. Patients. Seventeen preterm infants with DCI and 25 infants without DCI, with gestational age younger than 28 weeks and birth weight less than 1000 g, inborn and outborn admitted to the intensive care nursery between January 1992 and September 1993. Methods. All preterm infants diagnosed with DCI at younger than 35 days of age were identified using a perinatal and neonatal database. DCI was defined as a blood, cerebrospinal fluid, or two urine cultures positive for Candida requiring antifungal therapy. A control group of uninfected infants matched for the major risk factors for DCI (gestational age, birth weight, duration of intubation, broad-spectrum antibiotics, and IV alimentation, including lipids and central venous catheters) admitted during the same period was identified using the same database. Postmatching comparison was performed for several other factors to detect any other differences between the groups. Results. The infants with DCI (n = 17) and control infants (n = 25) had no statistical difference in exposure to the major risk factors for DCI or in postmatching comparison. Ten (59%) of the infants with DCI were receiving HC at the time of infection, whereas four (16%) of the control infants received HC during the first 35 days of life. Infants with DCI were 7.5 times as likely as control infants (95% confidence interval, 5 to 11) to have received IV HC before the onset of fungal infection. Conclusion. We conclude that the administration of IV HC significantly increases the risk of DCI in susceptible preterm infants younger than 35 days of age. The potentially serious risks of DCI should be considered particularly in the patient selection process for administration of IV HC.

Sign in / Sign up

Export Citation Format

Share Document