Evaluation of DNA-binding and DNA-photocleavage ability of tetra-cationic porphyrins containing peripheral [Ru(bpy)2Cl]+ complexes: Insights for photodynamic therapy agents

The new complex [Rh 2 (phen) 2 (CH 3 CN) 6 ](BF 4 ) 4 ( 1 ) was synthesized and characterized in solution and its crystal structure was determined. Irradiation of 1 with visible light ( λ irr >590 nm) in water results in the release of two equatorial CH 3 CN ligands, CH 3 CN eq , as well as in the formation of mononuclear radical Rh(II) fragments stemming from the homolytic photocleavage of the metal–metal bond. The photoproducts, identified by electrospray ionization mass spectrometry, include [Rh(phen)(CH 3 CN)(OH)] + and [Rh(phen)(CH 3 CN)(H 2 O) 3 (BF 4 )] + . The quantum yield for the photochemical transformation of 1 in H 2 O exceeds unity ( Φ 550 nm =1.38) indicative of dark reactions following the initial photoprocess. DNA photocleavage was observed for 1 ( λ irr >590 nm), whereas the complex is unreactive in the dark. This feature makes 1 a promising photodynamic therapy agent that does not operate via the production of singlet oxygen, 1 O 2 .

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A Fluorinated Ruthenium Porphyrin as a Potential Photodynamic Therapy Agent: Synthesis, Characterization, DNA Binding, and Melanoma Cell Studies

Inorganic Chemistry ◽

10.1021/ic8015589 ◽

2008 ◽

Vol 47 (23) ◽

pp. 11278-11283 ◽

Cited By ~ 51

Author(s):

Sandya Rani-Beeram ◽

Kyle Meyer ◽

Anna McCrate ◽

Yiling Hong ◽

Mark Nielsen ◽

...

Keyword(s):

Photodynamic Therapy ◽

Dna Binding ◽

Melanoma Cell ◽

Ruthenium Porphyrin

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Synthesis, characterization and DNA-binding and DNA-photocleavage studies of two Ru(II) complexes containing two main ligands and one ancillary ligand

Polyhedron ◽

10.1016/j.poly.2011.04.047 ◽

2011 ◽

Vol 30 (12) ◽

pp. 1953-1959 ◽

Cited By ~ 12

Author(s):

Jing Sun ◽

Shuo Wu ◽

Huo-Yan Chen ◽

Feng Gao ◽

Jie Liu ◽

...

Keyword(s):

Dna Binding ◽

Ancillary Ligand ◽

Dna Photocleavage

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Synthesis, DNA binding, docking and photocleavage studies of quinolinyl chalcones

MedChemComm ◽

10.1039/c4md00185k ◽

2014 ◽

Vol 5 (11) ◽

pp. 1708-1717 ◽

Cited By ~ 8

Author(s):

P. J. Bindu ◽

K. M. Mahadevan ◽

T. R. Ravikumar Naik ◽

B. G. Harish

Keyword(s):

Dna Binding ◽

Dna Photocleavage ◽

Nucleolytic Activity

A series of simple quinoline–chalcone conjugates have been synthesized and evaluated for their nucleolytic activity. The compounds 3c and 3d exhibited promising DNA binding and DNA photocleavage studies.

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Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(II) and Pd(II) complexes. Insights for photodynamic therapy applications

Dalton Transactions ◽

10.1039/d1dt03565g ◽

2022 ◽

Author(s):

Isadora Tisoco ◽

Maria Carolina Donatoni ◽

Henrique Victória ◽

José Roberto de Toledo ◽

Klaus Krambrock ◽

...

Keyword(s):

Photodynamic Therapy ◽

Elemental Analysis ◽

Synthesis And Characterization ◽

Polypyridyl Complexes ◽

Cationic Porphyrins ◽

Peripheral Position

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(II) or Pd(II) polypyridyl complexes attached at the peripheral position of N4-macrocycle. Compounds were characterized through elemental analysis,...

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